Traditional Chinese medicine composition with memory improving efficacy and preparation method thereof
A technology for improving memory and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effects of reasonable design, memory improvement and sleep improvement
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Embodiment 1
[0026] A Chinese medicinal composition for improving memory and health food is made of the following raw materials in parts by weight: 60 g of rehmannia glutinosa, 30 g of cornus, 30 g of yam, 15 g of Polygala, 15 g of Yizhiren.
[0027] The method for preparing health food by using the above-mentioned Chinese medicine composition is as follows:
[0028] Step (1), decocting: put Rehmannia glutinosa, dogwood, yam, Polygala, and Yizhiren into a decocting bag, soak in water for 30 minutes, decoc 2 times, add 10 times the total weight of the raw materials for the first time. Cook for 1 hour, add 8 times the total weight of the raw materials and cook for 45 minutes for the second time, combine the two decoctions, squeeze the medicine residue, and filter to obtain the water decoction;
[0029] Step (2), concentration and drying: heating and concentrating the water extract to the extract; combining the two filtrates to obtain the extract; concentrating the extract to obtain a thick extract;...
Embodiment 2
[0062] A Chinese medicinal composition for improving memory and health food is made of the following raw materials in parts by weight: 60 g of rehmannia glutinosa, 30 g of cornus, 30 g of yam, 15 g of polygala, and 45 g of Yizhiren.
[0063] The method for preparing health food by using the above-mentioned Chinese medicine composition is as follows:
[0064] Step (1), decocting: put Rehmannia glutinosa, dogwood, yam, Polygala, and Yizhiren into a decocting bag, soak in water for 30 minutes, decoc 2 times, add 10 times the total weight of the raw materials for the first time. Cook for 1 hour, add 8 times the total weight of the raw materials and cook for 45 minutes for the second time, combine the two decoctions, squeeze the medicine residue, and filter to obtain the water decoction;
[0065] Step (2), concentration and drying: heat and concentrate the water extract to an extract; combine the two filtrates to obtain an extract; concentrate the extract to obtain a thick extract; at a v...
Embodiment 3
[0098] Mice oral acute toxicity test (MTD):
[0099] 1. Animal source: Sibefu (Beijing) Biotechnology Co., Ltd., KM mice, laboratory animal quality certificate: No.1103241911023787.
[0100] 2. Dosage design: Choose 40 Kunming mice of 18g~21g, half male and half for experiment. During the experiment, the animals freely eat and drink. Gavage the stomach at a dose of 20ml / kg BW twice, with an interval of 6 hours, equivalent to 46g crude drugs / kg BW (equivalent to 230 times the daily intake of the human body), observe continuously for 14 days, observe and record the general state and weight of the animal Changes, signs of poisoning and death, etc., determine the maximum tolerated dose (MTD).
[0101] 3. Way of sample administration: intragastric administration with an intragastric volume of 20ml / kg BW.
[0102] 4. Test results
[0103] Gavage the tested samples twice to mice of both sexes at a dose of 46g crude drug / kg BW. During the 14 days of observation, the animals were in normal st...
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