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Novel flavonoid compound Hip A and application thereof

A technology of flavonoids and compounds, applied in applications, sugar derivatives, food science, etc., to achieve the effect of realizing waste utilization, expanding clinical applications, and inhibiting cell lipid production

Active Publication Date: 2020-09-08
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, there are still many active substances contained in seabuckthorn that have not been isolated and identified. If we can conduct more in-depth and subtle research on the new chemical components and their pharmacological effects in seabuckthorn and discuss their active mechanisms, it is expected to develop more. Safe and effective natural plant-derived medicines that can treat diseases

Method used

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  • Novel flavonoid compound Hip A and application thereof
  • Novel flavonoid compound Hip A and application thereof
  • Novel flavonoid compound Hip A and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] The preparation of embodiment 1 new flavonoid compound

[0059] 1. Preparation of components

[0060] (1) 20.00kg of seabuckthorn (Hippophae rhamnoides Linn.) seed meal was extracted in 70% ethanol solution, the ratio of solid to liquid was 1:20kg / L, extracted for 2 hours each time, the temperature was 60°C, extracted 3 times, and the extracts were combined for 3 times Then concentrate under reduced pressure to obtain 3.50 kg of ethanol extract of seabuckthorn seed meal.

[0061] (2) Freeze-dry the alcohol extract, crush it through a 120-mesh sieve, add a small amount of methanol, mix it with 200-300-mesh normal-phase silica gel at a ratio of 1:1, and volatilize until there is no alcohol smell. Add 7kg 200~300 mesh normal phase silica gel in the glass chromatography column, use dichloromethane:methanol:water=7:3:0.5 to do mobile phase to carry out elution, elution volume is 20 column volumes, to eluent Concentrate under reduced pressure to obtain extract.

[0062] (3...

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Abstract

The invention discloses a new flavonoid Hip A and application thereof. The new flavonoid Hip A is prepared by the following steps: eluting a sea buckthorn seed meal extract by an MCI gel column, and then performing semi-preparative separation by a C18 chromatographic column, a diol chromatographic column and a C18 chromatographic column in sequence to obtain the new flavonoid Hip A. The inventionalso provides an application of the new compound Hip A in preparation of a drug for preventing and / or treating lipid metabolism disorder. Through activity research on the compound Hip A, it is verified that the compound Hip A can inhibit cell lipid generation and can be used for preparing drugs for preventing or treating obesity, hyperlipidemia and other lipid metabolism disorder diseases.

Description

technical field [0001] The invention relates to the field of new flavonoid compounds and their medical application, in particular to the new flavonoid compound HipA and its application. Background technique [0002] Seabuckthorn (Latin scientific name: Hippophae rhamnoides Linn.) is a deciduous shrub of the family Echinaceae and the genus Hippophae. It is characterized by drought resistance, wind and sand resistance, and can survive on salinized land, so it is widely used in soil and water conservation. . Seabuckthorn is grown in large quantities in northwest China for desert greening. [0003] Seabuckthorn is rich in nutrients, including active substances such as vitamins, flavonoids, triterpenoids, oils and fatty acids, phenols, volatile oils, trace elements, phospholipids, 5-hydroxytryptamine, and various amino acids and proteins needed by the human body. [0004] Seabuckthorn seeds are often used to extract oil to make seabuckthorn oil. Seabuckthorn oil contains 206 ki...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07A61K31/7048A61P3/00A61P3/06A61P3/04A61P9/12A61P9/00A23L33/105
CPCC07H17/07A61K31/7048A61K31/7034A61P3/00A61P3/06A61P3/04A61P9/12A61P9/00A23L33/105A23V2002/00A61K2300/00A23V2200/332A23V2200/326A23V2200/30A23V2200/3262A23V2250/2116
Inventor 王洪伦铁芳芳丁金
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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