Pharmaceutical composition for treating pelvic floor achalasia constipation and preparation method thereof

Abstract

The invention discloses a pharmaceutical composition for treating pelvic floor achalasia constipation and a preparation method thereof. The pharmaceutical composition for treating the pelvic floor achalasia constipation mainly comprises a pharmaceutically acceptable osmotic laxative and an anti-anxiety drug, wherein the osmotic laxative and the anti-anxiety drug are proportioned in a weight ratioof (2-8) to 1. The pharmaceutical composition for treating the pelvic floor achalasia constipation adopts a drug combination with significant synergistic effects, and a specific drug ratio is utilizedso as to significantly reducing toxic and side effects of the two drugs on the human body; and moreover, the pharmaceutical composition is capable of significantly reducing pressure on anal muscles,especially on the physiological sphincter, as well as decreasing anorectal maximal autonomic systolic pressure and anorectal resting pressure. Thus, the pharmaceutical composition for treating the pelvic floor achalasia constipation has improved curative effects, and has broad prospects of medical application.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating pelvic floor achalasia type constipation and a preparation method thereof. Background technique [0002] Constipation is one of the most common gastrointestinal symptoms clinically. It often manifests as strained defecation, decreased frequency of defecation, induration or dry ball of defecation, feeling of incomplete defecation, anorectal blockage, and even assisted defecation with manipulation. Chronic constipation has been underestimated by people for quite a long time in the past. In recent years, the prevalence of constipation has gradually increased, and studies have shown that it is closely related to acute cardiovascular and cerebrovascular diseases, dementia, and colorectal cancer. More and more attention. [0003] The Rome II standard was introduced in 2000, and the international concept of constipation uses the Ro...

AI Technical Summary

Problems solved by technology

However, the course of biofeedback therapy is long, and the whole process requires continuous training of patients, which increases the burden of treatment on the one hand, and on the other hand, the final success rate of this method is low

[0009] In severe cases, surgical intervention is required. Studies have shown that most surgical treatments can achieve good results in the early stage, but the disease is prone to relapse with the passage of time. In addition, the re-formation of postoperative scars will cause postoperative defecation problems in patients recurrence, the long-term treatment effect of surgical treatment is not good

[0010] According to the analysis, the current methods for the treatment of pelvic floor achalasia constipation lack a drug with good therapeutic effect, quick effect and long-lasting effect. It is urgent for researchers to solve the above problems

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