Module for Raman detection and preparation method thereof

Abstract

The invention provides a module for Raman detection and a preparation method thereof. The module includes a substrate, the plurality of conical grooves formed in the substrate in a manner that the conical tips face downwards, nanoparticles aggregated in the vicinity of the conical tips of the plurality of conical grooves, and to-be-detected molecules arranged in the plurality of conical grooves and covering the nano particles. According to the method, effective aggregation of the nanoparticles can be promoted, the usage amount of the nanoparticles can be effectively reduced, the raw material cost can be saved, and the sensitivity and repeatability of Raman detection can be effectively improved.

Description

technical field [0001] The invention relates to the field of Raman detection, in particular to a module for Raman detection and a preparation method thereof. Background technique [0002] Surface-enhanced Raman scattering (SERS) technology has gradually attracted attention because of its high sensitivity, fast detection speed, and ability to provide fingerprint spectra. In the detection process, the more common reinforcing substrates are nanoparticles and liquid nanosols. The distribution pattern of the substrate is closely related to the sensitivity and repeatability of the detection. Therefore, realizing the aggregation of nanoparticles and the reproducible distribution of multiple points can effectively improve the Raman detection effect. [0003] When the reinforcing substrate is nanoparticles, the degree of dispersion of nanoparticles in the liquid is often uncontrollable during the drying process after titration of the liquid sol, which will result in poor dispersion...

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Problems solved by technology

[0003] When the reinforcing substrate is nanoparticles, the degree of dispersion of nanoparticles in the liquid is often uncontrollable during the drying process after titration of the liquid sol, which will result in poor dispersion uniformity of the prepared nanoparticles and lead to Raman The relative error of strength is large, and substrate raw materials will be wasted

[0004] When the enhanced substrate is a liquid nano-sol, the corresponding traditional liquid Raman detection is generally carried out in a capillary glass tube, which has the problems of difficulty in focusing the Raman laser and taking a long time

[0005] In the existing research in the industry, some people use a Raman detection tool with a cylindrical groove array. Although this tool has improved the degree of aggregation of nanoparticles, it still has a low degree of aggregation, and the amount of nanoparticles used is not economical enough. Disadvantages such as low effect

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