A kind of oral nano drug delivery system of nuciferine and its preparation method

A drug delivery system and a technology for lotus leaf alkaloid are applied in the field of oral nano drug delivery system of lotus leaf alkaloid and its preparation field, which can solve the problems of inconvenience and pain of patients, reduce food intake, reduce total cholesterol, and achieve an effective and convenient drug delivery method Effect

Inactive Publication Date: 2017-07-21
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, cardiovascular and cerebrovascular diseases caused by hyperlipidemia require long-term medication, and injection administration brings great inconvenience and pain to patients.

Method used

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  • A kind of oral nano drug delivery system of nuciferine and its preparation method
  • A kind of oral nano drug delivery system of nuciferine and its preparation method
  • A kind of oral nano drug delivery system of nuciferine and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Preparation of Nuciferine Oral Nano-Drug Delivery System

[0050] Using polylactic-co-glycolic acid (PLGA) with sustained-release properties as the carrier material and nuciferine monomer (NUC) as the model drug, the NUC-PLGA sustained-release drug delivery system was prepared by phacoemulsification. The specific steps are as follows.

[0051] ① Precisely weigh 5 mg NUC with an electronic balance, and set aside.

[0052] ② Precisely weigh 50 mg PLGA with an electronic balance, dissolve it in an organic solvent (V 二氯甲烷 :V 丙酮 = 3:2), the solution was prepared with a concentration of 10 mg / ml, and the resulting solution was used as the oil phase for subsequent use. 1 g of bovine serum albumin (BSA) was accurately weighed, and deionized water was used as a solvent to prepare a solution with a concentration of 1% ( W / V) aqueous solution, and the obtained solution is used as an aqueous phase and an emulsifier for future use, and the aqueous phase and emulsifier m...

Embodiment 2

[0054] Example 2: Characterization of Nuciferine Oral Nanoparticles I

[0055] The differential scanning calorimetry experiment was carried out on a differential scanning calorimeter (model DSC200 F3 Maia) produced by NETZSCH, Germany. Weighed 3-5 mg of NUC-NPs, PLGA and NUC samples respectively, and heated them at room temperature to The temperature was raised linearly at a rate of 10°C / min to 550°C. During the test, high-purity nitrogen (99.99%) was used as the carrier gas, the flow rate of the protective gas was 50mL / min, and the flow rate of the purge gas was 20mL / min. The aluminum crucible was used as a reference , the system automatically collects data and obtains the differential scanning calorimetry (DSC) curves of NUC-NPs, PLGA and NUC, see figure 1 .

[0056] The results showed that the DSC curves of NUC-NPs did not overlap with the curves of PLGA and NUC, which proved that NUC-NPS had formed a stable nanosystem.

Embodiment 3

[0057] Example 3: Characterization of Nuciferine Oral Nanoparticles II

[0058] Weigh 3-5 mg of NUC-NPs, PLGA and NUC samples respectively; use an infrared spectrometer to measure their infrared scanning spectra, see figure 2 .

[0059] The results show that the wavelength at 3002cm -1 CH at NUC 3 characteristic peaks. Wavelength at 1680cm -1 is the characteristic peak of PLGA. NUC-NPs at 3002cm -1 and 1680cm -1 The peak shifted at , indicating that the groups of NUC and PLGA interacted with each other, proving that the preparation of NUC-NPs nanoparticles was successful.

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Abstract

The invention belongs to the technical field of medicinal preparations, and particularly relates to a nuciferine oral nano-administration system and a preparation method thereof. The system uses nuciferine as a medicinal material and PLGA as a carrier material, has the advantages of low toxicity, sensitive medicine hydrolysis prevention, drug release control, high bioavailability and the like. The preparation method of nuciferine nano-particles adopts an emulsion-solvent evaporation method, so that the stability of nuciferine can be improved, and the bioavailability of the nuciferine can be improved. Compared with lipidosome, the preparation prepared by the invention has the advantages of good stability, and a more effective and more convenient administration method is provided to application of nuciferine in blood fat reduction.

Description

[0001] Technical field: [0002] The invention relates to the technical field of pharmaceutical preparations, in particular to a nuciferine oral nano drug delivery system and a preparation method thereof. [0003] Background technique: [0004] Dyslipidemia is one of the main characteristics of metabolic syndrome, which is mainly manifested as an increase in total cholesterol in plasma, an increase in triglyceride lipoprotein levels, and a decrease in HDL-C levels. A large number of scientific studies have proved that the increase of plasma cholesterol, especially the concentration of low-density lipoprotein-cholesterol, is a risk factor for the occurrence of atherosclerosis, and the control and treatment of abnormal blood lipids are extremely important for reducing the occurrence and development of cardiovascular and cerebrovascular diseases. Significance. At present, statins, fibrates, niacin and its derivatives, bile acid chelating agents, and cholesterol absorption inhibito...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K31/473A61K47/34A61K47/42A61K47/28A61P3/06A61P3/10A61P39/06A61P9/06A61P21/02A61P1/06A61P3/04
Inventor 李晓宇刘皋林武鑫顾圣莹朱冠华柳莹
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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