Nipple sealing agent for non-human animals and preparation method thereof

A teat sealant and technology for animals, which is applied in the field of new non-human animal teat sealant and its preparation, can solve the problems of poor phase transition sensitivity and achieve soft properties, high safety, and simple preparation process

Active Publication Date: 2020-10-30
余祖功
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The single in situ gel system only responds to changes in one condition of the body's internal environment, and the phase change sensitivity is not good

Method used

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  • Nipple sealing agent for non-human animals and preparation method thereof
  • Nipple sealing agent for non-human animals and preparation method thereof
  • Nipple sealing agent for non-human animals and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] prescription

[0038]

[0039] The preparation method of carbomer gel: take 1.5g carbomer 934, add 128g water for injection, fully swell; take another 0.5g sodium hydroxide dissolved in 20g water, stir and add to the swollen carbomer solution, stir evenly , that is.

[0040] Preparation:

[0041] Step (1), taking each component according to the prescription amount;

[0042] Step (2), take by weighing the chitosan powder of prescription quantity, add 500g 1% (v / v) acetic acid solution, stir until chitosan dissolves at temperature 40~60 ℃, obtain chitosan solution; Take prescription quantity chlorobutanol and low acetyl gellan gum, dissolved in chitosan solution, added the prescribed amount of carbomer gel and mixed evenly, then sprinkled the prescribed amount of poloxamer 407, 188 and xanthan gum on the On the liquid surface, refrigerate at a temperature of 4°C until a lump-free, uniformly dispersed solution is obtained;

[0043] Step (3), adding water for injecti...

Embodiment 2

[0051] prescription

[0052]

[0053] The preparation method of carbomer gel: take 2.0g carbomer 940, add it to 76g water for injection, and fully swell; take another 2.0g triethanolamine and dilute it with 20g water, stir and add it to the swollen carbomer solution, stir Evenly, that is.

[0054] Preparation:

[0055] Step (1), taking each component according to the prescription amount;

[0056] Step (2), take by weighing the chitosan powder of recipe quantity, add 500g 0.3% (v / v) citric acid solution, stir until chitosan dissolves at temperature 40~60 ℃, obtain chitosan solution; Take Dissolve the prescribed amount of ethyl p-hydroxybenzoate and gellan gum with chitosan solution, add the prescribed amount of carbomer gel and mix evenly, then add the prescribed amount of poloxamer 407, 188 and hypromellose Sprinkle the vegetable on the liquid surface and refrigerate at a temperature of 4°C until a lump-free and evenly dispersed solution is obtained;

[0057] Step (3), ...

Embodiment 3

[0060] prescription

[0061]

[0062] The preparation method of carbomer gel: take 3.0g carbomer 980, add it to 76g water for injection, and fully swell; take another 1.0g sodium hydroxide and dissolve it in 20g water, stir and add it to the swollen carbomer solution, Stir well and serve.

[0063] Preparation:

[0064] Step (1), taking each component according to the prescription amount;

[0065] Step (2), take the chitosan powder of recipe quantity, add in the 1% (v / v) acetic acid solution of 500g, stir until chitosan dissolves at temperature 40~60 ℃, obtain chitosan solution; Take Dissolve the prescribed amount of chlorobutanol and low-acetyl gellan gum with chitosan solution, add the prescribed amount of carbomer gel and mix evenly, then add the prescribed amount of poloxamer 407, 188 and xanthan gum Sprinkle on the liquid surface and refrigerate at 4°C until a lump-free, evenly dispersed solution is obtained;

[0066] Step (3), adding water for injection to obtain a...

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PUM

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Abstract

The invention discloses a nipple sealing agent for non-human animals. The nipple sealing agent is prepared from the following components in percentage by mass: 11 to 40 percent of temperature-sensitive in-situ gel matrix, 0.001 to 2 percent of ion-sensitive in-situ gel matrix, 5 to 20 percent of carbomer gel, 0.02 to 8 percent of chitosan, 0.01 to 5 percent of polymer retardant, 0.001 to 2 percentof bacteriostatic agent and the balance of water for injection, wherein the temperature-sensitive in-situ gel matrix is poloxamer, and the ion-sensitive in-situ gel matrix is gellan gum. The nipple sealing agent is mainly based on an in-situ gel system, the sensitivity to the environment in the nipple is greatly improved, the environment in the nipple can be perceived in time, and gelling is rapidly generated; the chitosan is added so that the gel strength can be effectively improved, a compact barrier can be formed, and invasion of pathogenic bacteria is hindered. The gel matrix is good in biocompatibility, can be adhered to the inner wall of a nipple hole, and can be remained in the nipple hole for a long time to cover the whole dry period.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations for animals, and relates to a novel teat sealant for non-human animals and a preparation method thereof. Background technique [0002] Mastitis is one of the most common and economically damaging diseases of dairy cows. According to reports, about 30% of dairy cows in the world suffer from different types of mastitis, and the prevalence of recessive mastitis is as high as 50%. NMC (National Mastitis Committee of the United States) has reported that in the United States, the United Kingdom, and Japan, the incidence rates of cow mastitis are 45%, 40%-50%, and 45.1%, respectively. In my country, the incidence of mastitis in dairy cows is as high as 50% to 80%, and the incidence of recessive mastitis is as high as 25% to 68%. [0003] The occurrence of mastitis in dairy cows is closely related to pathogenic microorganisms, cows' own factors, environmental factors, management factors and ge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/32A61K47/10A61K31/045A61K31/216A61K31/05A61P15/14
CPCA61K9/0019A61K9/0041A61K9/06A61K47/36A61K47/32A61K47/10A61K31/045A61K31/216A61K31/05A61P15/14Y02A50/30
Inventor 余祖功郭凡溪
Owner 余祖功
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