Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of method for measuring polymer in cefuroxime axetil tablet

A high-molecular polymer, cefuroxime axetil technology, applied in the field of analysis, can solve problems such as inability to store for a long time, sample decomposition, stability of the item to be tested, and lack of concern for method applicability

Active Publication Date: 2022-04-01
JIANGSU QINGJIANG PHARMA
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the instability of β-lactam antibiotic solution, it cannot be stored for a long time, and long-term storage will cause sample decomposition
The stability and applicability of the existing methods for the tested items have not yet attracted attention

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of method for measuring polymer in cefuroxime axetil tablet
  • A kind of method for measuring polymer in cefuroxime axetil tablet
  • A kind of method for measuring polymer in cefuroxime axetil tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The selection of embodiment 1 solvent

[0015] Instruments and reagents

[0016] Instruments: water bath, balance;

[0017] Reagents: N,N-dimethylformamide, methanol, ethanol, n-propanol, isopropanol, n-butanol, n-pentanol, n-hexanol, n-octanol, water.

[0018] Solvent selection:

[0019] Add 10ml of N,N-dimethylformamide, add 20mg of cefuroxime axetil tablet powder, keep warm and shake in a 30°C water bath, the sample can be completely dissolved;

[0020] Methanol 10ml, add 20mg of cefuroxime axetil tablet powder, keep warm and shake in 30℃ water bath, the sample can be completely dissolved;

[0021] Add 10ml of ethanol, add 20mg of cefuroxime axetil tablet powder, keep warm and shake in a 30°C water bath, the sample can be completely dissolved;

[0022] Add 10ml of n-propanol, add 20mg of cefuroxime axetil tablet powder, keep warm and shake in a 30°C water bath, the sample can be completely dissolved;

[0023] Add 10ml of isopropanol, add 20mg of cefuroxime axeti...

Embodiment 2

[0030] The selection of embodiment 2 absorption wavelength

[0031] N, N-dimethylformamide 10ml, add 20mg of cefuroxime axetil tablet powder, with air as a reference, measure the maximum absorption wavelength;

[0032] Methanol 10ml, add the cefuroxime axetil tablet powder of 20mg, take air as reference, measure the maximum absorption wavelength;

[0033] Ethanol 10ml, add 20mg of cefuroxime axetil tablet powder, with air as a reference, measure the maximum absorption wavelength;

[0034] Add 20 mg of cefuroxime axetil tablet powder to 10 ml of n-propanol, and measure the maximum absorption wavelength with air as a reference;

[0035] Isopropanol 10ml, add 20mg of cefuroxime axetil tablet powder, with air as a reference, measure the maximum absorption wavelength;

[0036] 10ml of n-butanol, add 20mg of cefuroxime axetil tablet powder, with air as a reference, measure the maximum absorption wavelength;

[0037] 10ml of n-amyl alcohol was added to 20mg of cefuroxime axetil po...

Embodiment 3

[0041] The test of embodiment 3 solution stability

[0042] Detection wavelength: 280nm

[0043] Column temperature: 30°C

[0044] Injection volume: 20µl

[0045] Flow rate: 0.33ml / min

[0046] Mobile phase: 0.03 mol / L lithium bromide in N,N-dimethylformamide

[0047] Chromatographic column: TSKgelG2000Hhr (7.8mml.D.×30cm)

[0048] Sample Preparation:

[0049] N,N-Dimethylformamide 10ml, add 20mg of cefuroxime axetil tablet powder;

[0050] Methanol 10ml, add 20mg of cefuroxime axetil tablet powder;

[0051] 10ml of ethanol, add 20mg of cefuroxime axetil tablet powder;

[0052] 10ml of n-propanol, add 20mg of cefuroxime axetil tablet powder;

[0053] 10ml of isopropanol, add 20mg of cefuroxime axetil tablet powder;

[0054] 10ml of n-butanol, add 20mg of cefuroxime axetil tablet powder;

[0055] 10ml of n-amyl alcohol, add 20mg of cefuroxime axetil tablet powder;

[0056] 10ml of n-hexanol, add 20mg of cefuroxime axetil tablet powder;

[0057] 10ml of n-octanol, ad...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
wavelengthaaaaaaaaaa
wavelengthaaaaaaaaaa
wavelengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for determining high-molecular polymers in cefuroxime axetil tablets, which comprises the following steps: the chromatographic conditions include a high-efficiency gel chromatographic column, the detector is UV, and the mobile phase is 0.03 mol / L lithium halide at 25- 35% N,N-dimethylformamide solution containing monoalcohols with 3 to 8 carbon atoms. The method of the present invention has better solution stability, can effectively prevent the degradation of the cefuroxime axetil component to be tested, and ensure the stability of the sample, so that the high molecular polymer in the cefuroxime axetil tablet can be more accurately controlled, and the product can be guaranteed. Quality, prevention of allergic reactions caused by polymers, and better protection of drug safety for patients.

Description

technical field [0001] The invention relates to the technical field of analysis, in particular to a method for detecting high molecular weight polymers in cefuroxime axetil tablets. Background technique [0002] Cefuroxime axetil is a β-lactam antibiotic and is one of the drugs commonly used in clinic. The most common clinical adverse reaction is anaphylaxis. The current research results reveal that the allergens that trigger allergic reactions are not the antibiotics themselves, but the high molecular polymers in them. Therefore, the pharmaceutical industry in various countries conducts research on the high molecular polymers in them. In order to pursue better detection results, chromatographic columns and their fillers for the separation of high molecular polymers in β-lactam antibiotics are emerging. However, people's attention is mainly focused on the separation effect of the chromatographic column, peak shape tailing, column packing repeatability, analysis time and so ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/86
CPCG01N30/02G01N30/06G01N30/8634
Inventor 王崇益陈加罡黄伟周晶晶隽海龙
Owner JIANGSU QINGJIANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com