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A wound covering and preparation method thereof

A covering and wound technology, applied in the field of wound covering and its preparation, can solve the problems of long healing time and lack of biological activity of the wound, and achieve the effect of accelerating tissue epithelialization, excellent mechanical strength, and promoting wound healing

Active Publication Date: 2021-10-01
ZHENDE MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a good mechanical dressing to solve the defects that the existing dressing does not have biological activity, the wound healing time is long, and the wound needs to be changed many times during the treatment, which will cause bleeding of new granulation tissue and pain of the patient. A wound covering with good performance and biocompatibility and the function of promoting wound healing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The present invention provides a kind of preparation method of wound cover, comprises the following steps:

[0035] 1) Construction of collagen-mussel mucin film

[0036] 1) Take mussel mucin and dissolve it in 0.0001mol / L glacial acetic acid solution to prepare mussel mucin stock solution with a concentration of 0.4%;

[0037] 2) Take 5 parts of the above stock solution and dilute to 20 parts with water; dissolve the collagen in the above mussel mucin glacial acetic acid aqueous solution, stir and dissolve fully, so that the concentration of collagen is 0.5%, and the concentration of mussel mucin is 0.1% ;

[0038] 3) Inject the above solution into a 30*30cm stainless steel plate with a solution height of 5mm; put the stainless steel plate into a freeze dryer, and vacuum freeze-dry it at -10°C and 10-50Pa for 10 hours; then quickly place the plate The temperature rises to 10°C, and the system pressure is adjusted to 300-500Pa (Before the temperature rise, because the...

Embodiment 2

[0046] The invention provides a kind of preparation method of wound cover, comprises the following steps:

[0047] 1) Construction of collagen-mussel mucin film

[0048] 1) Take mussel mucin and dissolve it in 0.0001mol / L glacial acetic acid solution to prepare mussel mucin stock solution with a concentration of 0.4%;

[0049] 2) Take 5 parts of the above stock solution and dilute to 20 parts with water; dissolve the collagen in the above mussel mucin glacial acetic acid aqueous solution, stir and dissolve fully, so that the concentration of collagen is 0.3%, and the concentration of mussel mucin is 0.1% ;

[0050]3) Inject the above solution into a 30*30cm stainless steel plate with a solution height of 12.5mm; put the stainless steel plate into a freeze dryer, and vacuum freeze-dry it at -10°C and 10-50Pa for 15 hours; then quickly place the plate The temperature of the layer is raised to 10°C, and the system pressure is adjusted to 300-500Pa, so that before the collagen s...

Embodiment 3

[0058] The present invention provides a kind of preparation method of wound cover, comprises the following steps:

[0059] 1) Construction of collagen-mussel mucin film

[0060] 1) Take mussel mucin and dissolve it in 0.0001mol / L glacial acetic acid solution to prepare mussel mucin stock solution with a concentration of 0.4%;

[0061] 2) Take 1 part of the above stock solution and dilute it to 20 parts with water; dissolve the collagen in the above-mentioned mussel mucin glacial acetic acid aqueous solution, stir and dissolve fully, so that the concentration of collagen is 0.4%, and the concentration of mussel mucin is 0.02% ;

[0062] 3) Inject the above solution into a 30*30cm stainless steel plate with a solution height of 2.4mm; put the stainless steel plate into a freeze dryer, and vacuum freeze-dry it at -10°C and 10-50Pa for 7 hours; then quickly place the plate The temperature of the layer is raised to 10°C, and the system pressure is adjusted to 300-500Pa, so that b...

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Abstract

The invention relates to a wound covering which has good biocompatibility and can accelerate wound healing and a preparation method thereof. The wound covering comprises a thin film; the thin film is made of a carrier with good biocompatibility and high mechanical strength. It is prepared with a protein containing a dopa group; the carrier is collagen; and the protein containing a dopa group is mussel mucin. In the present invention, collagen and mussel mucin are mixed, and a dry membrane is made by semi-lyophilization under low temperature conditions, and then the mussel mucin is fixed on the collagen by chemical crosslinking, and the residual crosslinking agent is removed by rinsing. After being stored in the preservation solution, the stability of the protein structure is enhanced and the activity of collagen and mussel mucin is maintained. The collagen matrix has excellent mechanical strength and can be trimmed into any shape; it can accelerate tissue epithelialization and promote wound healing. Healing; good biocompatibility; no adhesion to the wound surface, no secondary damage to the wound surface.

Description

technical field [0001] The invention relates to a medical material, in particular to a wound covering which has good biocompatibility and can accelerate wound healing and a preparation method thereof. Background technique [0002] The main function of medical dressings is to cover and protect damaged skin, and at the same time provide an environment conducive to wound healing. [0003] Existing solutions mostly use Vaseline oil gauze, hydrocolloid dressings and other non-biologically active dressings to cover the skin donor area or burn wounds, but its disadvantages are: (1) The wound healing time is longer; (2) The wound surface during treatment Multiple dressing changes are required, which can cause bleeding of new granulation tissue and pain in patients. Contents of the invention [0004] The purpose of the present invention is to provide a good mechanical dressing to solve the defects that the existing dressing does not have biological activity, the wound healing time...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/42A61L15/46A61L15/44
CPCA61L15/225A61L15/32A61L15/325A61L15/42A61L15/46A61L15/44A61L2300/252A61L2300/404A61L2300/412C08L89/00A61L26/0033A61L26/0066A61L15/58A61L2300/214A61L2300/216
Inventor 张锐鲁建国赵鲁苹宫宇
Owner ZHENDE MEDICAL CO LTD
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