Application of d-leucine and chlorhexidine composition

A technology of chlorhexidine and leucine, which is applied in the field of medicine and health, can solve the problem of not finding the cariogenic Streptococcus mutans of the combination of D-leucine and chlorhexidine, and achieves reduction of adverse reactions, reduction of use concentration, Enhanced killing effect

Active Publication Date: 2021-11-23
HOSPITAL OF STOMATOLOGY CHINA MEDICAL UNIV
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Problems solved by technology

However, there is no report on the related technology of D-leucine and chlorhexidine composition in inhibiting cariogenic Streptococcus mutans

Method used

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  • Application of d-leucine and chlorhexidine composition
  • Application of d-leucine and chlorhexidine composition
  • Application of d-leucine and chlorhexidine composition

Examples

Experimental program
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Effect test

Embodiment

[0025] Example D-leucine enhances the bactericidal effect of chlorhexidine on cariogenic mutans Streptococcus related experimental research.

[0026] 1. Antibacterial experiment.

[0027] 1. Grouping of antibacterial experiments.

[0028] The first group: no treatment group (control group).

[0029] The second group: 100ppm D-leucine group.

[0030] The third group: 1ppm chlorhexidine group.

[0031] The fourth group: 1 ppm chlorhexidine + 100 ppm D-leucine group.

[0032] The fifth group: 10ppm chlorhexidine group.

[0033] 2. Experimental content.

[0034] Streptococcus mutans was used in this study. Before the experiment, the bacteria were extracted from frozen glycerol and cultured in brain heart infusion broth (BHI, pH = 7.0) agar medium (AOBOX, China) at 37°C under anaerobic conditions (90% N 2 , 10% CO 2 ) 72h. The BHI medium was sterilized at 121°C for 15 minutes, and the colony of Streptococcus mutans was transferred to 50ml of BHI liquid medium, and cultured...

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Abstract

The invention belongs to the technical field of medicine and health, and relates to the application of D-leucine and chlorhexidine composition, in particular to the application of D-leucine and chlorhexidine composition in the preparation of medicines for preventing or treating dental caries. The present invention proves that D Leucine enhances the bactericidal effect of chlorhexidine to cariogenic Streptococcus mutans by experimental research. The mechanism is that D Leucine transforms Streptococcus mutans in biofilm state into planktonic Streptococcus mutans in dispersed state, Make streptococcus mutans easier to kill, thereby enhancing the killing effect of chlorhexidine to streptococcus mutans, by adding green compound D-leucine in oral antiseptic chlorhexidine, prepare D-leucine and chlorhexidine The composition kills cariogenic mutans streptococcus biofilm, greatly reduces the concentration of chlorhexidine used, reduces adverse reactions in clinical application of chlorhexidine, achieves the same bactericidal effect, and has clinical transformation prospects.

Description

technical field [0001] The invention belongs to the technical field of medicine and health, and relates to the application of D-leucine and chlorhexidine composition, in particular to the application of D-leucine and chlorhexidine composition in preparing medicines for preventing or treating dental caries. Background technique [0002] Dental caries is the number one disease of the oral cavity. Streptococcus mutans is considered to be the main pathogenic microorganism of the disease. It mainly causes dental caries through the formation of dental plaque biofilm on the tooth surface. In severe cases, it can develop into pulp disease and root apex week sickness. Caries can only occur and develop in the presence of dental plaque biofilm, so effective removal and control of dental plaque biofilm is the key to the prevention and treatment of dental caries. In the clinic, methods to reduce the number of Streptococcus mutans include mechanical removal and mouthwash. During orthodo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61K31/155A61P1/02A61P31/02
CPCA61K31/155A61K31/198A61P1/02A61P31/02A61K2300/00
Inventor 刘奕徐大可闫昱文郑博文郑颖吴昊鹏刘艺张明月安娜杨晓丰赵阳
Owner HOSPITAL OF STOMATOLOGY CHINA MEDICAL UNIV
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