A compound amplification system for analyzing micro-haplotypes of degraded samples and its construction method

A compound amplification system and haplotype technology, applied in the field of forensic medicine, can solve the problems that STR typing technology cannot obtain ideal typing results, allele loss, etc., and achieve the effect of high sensitivity and strong identification ability.
CN112063723BActive Publication Date: 2021-07-09SHANXI MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANXI MEDICAL UNIV
Publication Date
2021-07-09

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Abstract

The invention provides a micro-haplotype composite amplification system in the analysis of degraded sample materials, a construction method thereof and related haplotype frequencies. The present invention provides a group of genetic marker compositions totaling 23 micro-haplotypes and their rs numbers. According to the amplification primers of 23 micro-haplotypes, a complex amplification system of micro-haplotypes for the analysis of degraded samples was constructed. Also provided herein is a kit comprising amplification primers for the aforementioned 23 micro-haplotypes. The micro-haplotype complex amplification system provided by the invention can carry out forensic identification on degraded samples, and has high sensitivity and strong identification ability.
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Description

technical field

[0001] The invention belongs to the field of forensic medicine, and in particular relates to a micro-haplotype complex amplification system in the analysis of degraded specimens, a construction method thereof, and related haplotype frequencies. Background technique

[0002] Forensic physical evidence is mainly to solve the problem of personal identification in judicial practice. Personal identification is based on the same identification theory as the guiding principle, and scientifically identifies the genetic markers of on-site samples. Therefore, new, more stable, accurate, fast, and informative The development and utilization of a large number of human genetic markers has always been a hot spot in forensic research.

[0003] With the development of DNA analysis technology and its application in forensic science, people have gradually developed personal identification detection based on short tandem repeat (STR) length polymorphism and single nucleotide po...

Claims

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