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A kind of traditional Chinese medicine compound preparation for treating liver fibrosis and its preparation method and application

A technology for liver fibrosis and compound preparations, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, digestive systems, etc.

Active Publication Date: 2021-10-19
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no effective therapeutic strategy for hepatic fibrosis in clinical practice. How to effectively prevent and treat hepatic fibrosis is a major problem that plagues the medical community today.

Method used

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  • A kind of traditional Chinese medicine compound preparation for treating liver fibrosis and its preparation method and application
  • A kind of traditional Chinese medicine compound preparation for treating liver fibrosis and its preparation method and application
  • A kind of traditional Chinese medicine compound preparation for treating liver fibrosis and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: preparation of oral liquid

[0028] Take 30g of Artemisia annua, 20g of safflower, 10g of fig, 5g of sage, add 10 times the amount of 60% ethanol, heat and reflux extraction 3 times, each time for 2 hours, filter, combine the filtrates, concentrate under reduced pressure (temperature is 60 ~ 70°C, pressure 0.08Mpa) to relative density 1.05-1.10 (temperature 60-70°C), add 1% aspartame, 2% citric acid, stir well, let it stand for more than 12 hours, filter and pack , sterilized, and obtained.

Embodiment 2

[0029] Embodiment 2: capsule preparation

[0030] Take 30g of Artemisia annua, 20g of A. safflower, 10g of fig, and 5g of sage, add 10 times the amount of 60% ethanol, heat and reflux for extraction 3 times, each time for 2 hours. The extracts were combined, ethanol was recovered, concentrated and evaporated to dryness, dried under reduced pressure (temperature 60-70°C, pressure 0.08mpa), and pulverized into fine powder. Add ethanol to granulate, dry, and pack into capsules.

Embodiment 3

[0031] Embodiment 3: Granule preparation

[0032] Take 30g of Artemisia annua, 20g of safflower, 10g of fig, 5g of sage, add 10 times the amount of 60% ethanol, heat and reflux extraction 3 times, each time for 2 hours, filter, combine the filtrates, concentrate under reduced pressure (temperature is 60 ~ 70°C, pressure 0.08Mpa) to relative density 1.05-1.10 (temperature 60-70°C), add 2% aspartame, stir well, spray dry, dry granulate, pack with aluminum-plastic composite film, Instantly.

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Abstract

The invention relates to a compound traditional Chinese medicine preparation for treating liver fibrosis, which is prepared from artemisia annua, safflower safflower, fig, and scallion according to a certain weight distribution ratio. The preparation method is to add the above-mentioned raw materials to 60% ethanol 10 times the amount, heated and refluxed for 3 extractions, 2 hours each time. The extracts are combined, ethanol is recovered, concentrated, evaporated to dryness, and dried under reduced pressure, and appropriate amount of auxiliary materials corresponding to different dosage forms are added, and tablets, capsules, granules, pills, etc. are prepared by conventional preparation methods. According to the results of pharmacodynamic tests, the traditional Chinese medicine compound preparation of the invention has the effect of significantly improving liver fibrosis lesion damage.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation for treating liver fibrosis, a preparation method and application thereof, and belongs to the field of traditional Chinese medicine pharmacy. Background technique [0002] Viral hepatitis, alcoholic fatty liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease are common chronic liver diseases with high incidence worldwide, and a considerable part of them will develop into liver fibrosis, liver cirrhosis and even liver cancer. It is one of the major diseases that seriously endanger human health. Liver fibrosis is a common pathological process of various chronic liver diseases, and reversing liver fibrosis can block the progression of liver diseases. It is now clear that the pathogenesis of liver fibrosis is the excessive deposition of extracellular matrix (extracellular matrix, ECM). During liver fibrosis, a large amount of fibrous tissue mainly comp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P1/16
CPCA61K36/21A61K36/282A61K36/60A61K36/8945A61K2236/333A61K2236/39A61K2236/51A61P1/16A61K2300/00
Inventor 张自力王娴邵江娟张峰谭善忠郑仕中
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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