Composition of freeze-dried formulation, cosmetic kit for external use on skin including the same, and its use

A technology for skin external preparations and compositions, which is applied in the field of freeze-dried formulation compositions and skin external preparation cosmetic kits containing the same, can solve the problems of high-concentration use, slippery and sticky, etc., and achieves improved spreadability and small sticky feeling. , the effect of refreshing feeling of use

Pending Publication Date: 2021-02-09
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the unique slippery and sticky nature of hyaluronic acid, it is difficult to use it at high concentrations, and the use of hyaluronic acid in freeze-dried cosmetic formulations also has serious slippery and sticky problems.

Method used

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  • Composition of freeze-dried formulation, cosmetic kit for external use on skin including the same, and its use
  • Composition of freeze-dried formulation, cosmetic kit for external use on skin including the same, and its use
  • Composition of freeze-dried formulation, cosmetic kit for external use on skin including the same, and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069]

[0070]In an example, 20% by weight of sodium hyaluronate (sodium Hyaluronate) was dissolved in 0.25N NaOH, and then 0.1% by weight of BDDE was added, and crosslinking was performed at 37° C. for 24 hours. After cross-linking, the gel was neutralized with an equal amount of 0.25N HCl, and then fully washed with pure water to remove unreacted BDDE. The washed gel was pulverized into a size of 20 μm and 200 μm with a plunger mill. The gel content was quantified by dry content and carbazole analysis for hyaluronic acid.

[0071]

[0072] 5 g of cross-linked hyaluronic acid crushed to 20 μm, 10 g of low-molecular-weight hyaluronic acid with a molecular weight of about 3,000 Daltons, and 5 g of vitamin C were added to 980 g of purified water, and mixed with a homomixer. The mixture was poured into a mold and dried after being frozen to -20°C in a freeze dryer.

Embodiment 2

[0074] Add 5 g of cross-linked hyaluronic acid crushed to 200 μm prepared in Example 1, 10 g of low-molecular-weight hyaluronic acid with a molecular weight of about 3,000 Daltons, and 5 g of vitamin C into 980 g of purified water, and use a homogeneous mixer to to mix. The mixture was poured into a mold and dried after being frozen to -20°C in a freeze dryer.

experiment Embodiment 1

[0082] [Experimental Example 1] Characters

[0083] After freeze-drying, the results of confirming the properties of the dosage form, such as figure 1 As shown, the dosage forms of Example 1, Example 2, and Comparative Example 2 have a certain shape, but in the case of Comparative Example 1, there is a problem of fragmentation. From this, it was confirmed that the lyophilized dosage form cannot be maintained only with low-molecular-weight hyaluronic acid.

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Abstract

Disclosed is a composition of freeze-dried formulation which is mixed with a medium composition to be applied to the skin. Based on the total weight of the composition of freeze-dried formulation andthe medium composition, freeze-dried hyaluronic acid is present in an amount of 0.5 dry wt% or more. The freeze-dried hyaluronic acid includes crosslinked hyaluronic acid and low-molecular weight hyaluronic acid at a weight ratio of 1:5 to 3:1. Thus, the composition allows incorporation of a high concentration of hyaluronic acid capable of retaining a moisturizing protective film, while supplementing skin constitutional ingredients, provides a high moisturizing effect without slipperiness and stickiness, has a dried form and requires no preservative, or the like, and can stabilize an unstableactive ingredient.

Description

technical field [0001] The present invention relates to a freeze-dried formulation composition and a skin external preparation cosmetic kit (kit) containing the same. Background technique [0002] Freeze-dried cosmetics can also be used as preservative-free formulations because their formulations do not contain moisture, which is conducive to the loading of functional ingredients that are easily affected by moisture and solvents, and do not require preservative treatment. This freeze-dried cosmetic dosage form needs to be dissolved in a solvent such as water or essence before use, and depending on the dosage form, it may be inconvenient to use due to extremely slow dissolution speed or extremely low viscosity. [0003] In addition, hyaluronic acid is a biological component found in body fluids, eyeballs of cattle, cockscombs, bradycardia of animals, placenta, etc., and is present in high concentrations in connective tissues and skin in particular. In addition, hyaluronic ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/04A61Q19/00
CPCA61K8/735A61K8/042A61Q19/00A61K2800/30A61K2800/84A61Q19/007A61K8/0225A61K2800/412A61K8/676
Inventor 张志旭赵成衍崔庚浩
Owner AMOREPACIFIC CORP
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