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A device for rapid preparation of high-throughput droplet arrays based on spray assistance

A preparation device and droplet technology, which is applied in the field of high-throughput droplet array rapid preparation device, can solve the problems of expensive processing equipment, difficult processing, difficult sample addition and control operation, and achieve the effect of improving the uniformity of droplets

Active Publication Date: 2022-03-29
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the defects of the existing droplet technology, such as expensive processing equipment, high processing difficulty, complicated production method and high cost, difficulty in large-scale preparation, difficult sample addition and control operations, and short storage time, the purpose of the present invention is to provide a spray-based Auxiliary high-throughput droplet array rapid preparation device, in which by improving the settings of various components in the device and the corresponding working methods, compared with the existing technology, it can effectively solve the problem of droplet array preparation, control and further storage The problem, is a device for ultrafast formation of spray-assisted ultrahigh-throughput droplet arrays

Method used

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  • A device for rapid preparation of high-throughput droplet arrays based on spray assistance
  • A device for rapid preparation of high-throughput droplet arrays based on spray assistance
  • A device for rapid preparation of high-throughput droplet arrays based on spray assistance

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Embodiment 1

[0062] In this embodiment, the droplet generation and collection device consists of an atomization inlet, a sedimentation channel, a sedimentation pattern mask (that is, a mask with a pre-designed sedimentation pattern) and a collection interface (that is, a droplet collection interface) It consists of four parts.

[0063] like figure 1 As shown, the atomization generating device preferably adopts an ultrasonic atomizing sheet. In order to form a uniform and rapid droplet array, it is more appropriate to select a spray outlet aperture of about 5-9 microns. It is embedded in the bottle cap with screw cap, and the screw cap on the bottle cap is fixed and sealed with the settling channel to prevent the leakage of spray droplets. In this embodiment, the settling channel can be made of glass or plastic transparent material, so as to facilitate the observation of the aerosol settling process. The priority is to choose the common 500ml plastic bottle for modification, which is low ...

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Abstract

The invention belongs to the field of biological analysis and micro-manufacturing, and discloses a spray-assisted high-throughput droplet array rapid preparation device, which includes from top to bottom: an aerosol droplet generating device for atomizing liquid To form aerosol droplets, specifically, it is formed by connecting the atomizer and the base; the aerosol droplets restrict the settling channel, which is used to restrict the settlement and diffusion area of ​​the aerosol droplets, so that the settlement of the droplets and the collection area are controlled; the droplet collection interface is used to accept the droplets obtained after settling, and collect the droplet array. And it may be preferred to keep the droplets in air for at least seven days by means of a temperature differential supply assembly. The present invention can effectively solve the problems of liquid droplet array preparation, control and further storage by improving the arrangement of each component in the device and the corresponding working mode, and is a spray-assisted ultra-high-flux liquid droplet array ultra-fast forming device.

Description

technical field [0001] The invention belongs to the fields of biological analysis and micromanufacturing, and more specifically relates to a spray-assisted rapid preparation device for high-throughput droplet arrays. Using the device, rapid preparation of high-throughput droplet arrays can be realized, and hundreds of The ultra-low-cost generation of thousands of droplets, and at the same time, the selective preparation of space-controllable droplets can be realized through the mask, which can be stored in the air for more than ten days, providing a high-throughput droplet microenvironment. A new approach that can be widely used in miniaturized high-throughput applications such as microbial cultivation and screening, nanoparticle fabrication and assembly, sensor fabrication, and biochemical detection. Background technique [0002] In recent decades, the concepts of miniaturization and high-throughput quantification have developed rapidly in the field of biological and chemic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01F33/302B01F23/213B01J13/00
CPCB01J13/0095B01F23/2133B01F23/2132B01F33/3021B01F2101/2204
Inventor 刘笔锋黄习知陈鹏
Owner HUAZHONG UNIV OF SCI & TECH
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