A device for rapid preparation of high-throughput droplet arrays based on spray assistance

Abstract

The invention belongs to the field of biological analysis and micro-manufacturing, and discloses a spray-assisted high-throughput droplet array rapid preparation device, which includes from top to bottom: an aerosol droplet generating device for atomizing liquid To form aerosol droplets, specifically, it is formed by connecting the atomizer and the base; the aerosol droplets restrict the settling channel, which is used to restrict the settlement and diffusion area of ​​the aerosol droplets, so that the settlement of the droplets and the collection area are controlled; the droplet collection interface is used to accept the droplets obtained after settling, and collect the droplet array. And it may be preferred to keep the droplets in air for at least seven days by means of a temperature differential supply assembly. The present invention can effectively solve the problems of liquid droplet array preparation, control and further storage by improving the arrangement of each component in the device and the corresponding working mode, and is a spray-assisted ultra-high-flux liquid droplet array ultra-fast forming device.

Description

technical field [0001] The invention belongs to the fields of biological analysis and micromanufacturing, and more specifically relates to a spray-assisted rapid preparation device for high-throughput droplet arrays. Using the device, rapid preparation of high-throughput droplet arrays can be realized, and hundreds of The ultra-low-cost generation of thousands of droplets, and at the same time, the selective preparation of space-controllable droplets can be realized through the mask, which can be stored in the air for more than ten days, providing a high-throughput droplet microenvironment. A new approach that can be widely used in miniaturized high-throughput applications such as microbial cultivation and screening, nanoparticle fabrication and assembly, sensor fabrication, and biochemical detection. Background technique [0002] In recent decades, the concepts of miniaturization and high-throughput quantification have developed rapidly in the field of biological and chemic...

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Problems solved by technology

[0004] In view of the defects of the existing droplet technology, such as expensive processing equipment, high processing difficulty, complicated production method and high cost, difficulty in large-scale preparation, difficult sample addition and control operations, and short storage time, the purpose of the present invention is to provide a spray-based Auxiliary high-throughput droplet array rapid preparation device, in which by improving the settings of various components in the device and the corresponding working methods, compared with the existing technology, it can effectively solve the problem of droplet array preparation, control and further storage The problem, is a device for ultrafast formation of spray-assisted ultrahigh-throughput droplet arrays

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