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138 results about "Micro fabrication" patented technology

Laser differential confocal LIBS, Raman spectrum-mass spectrum imaging method and Raman spectrum-mass spectrum imaging device

The invention relates to a laser differential confocal LIBS, a Raman spectrum-mass spectrum imaging method and a Raman spectrum-mass spectrum imaging device and belongs to the technical fields of confocal microscopy imaging, mass spectrum imaging and spectral measurement. In the invention, the differential confocal microscopy imaging technology is combined with a spectrum and mass spectrum detection technology; a high-spatial-discrimination differential confocal system is used for axially focusing and imaging a sample; a mass spectrum detection system is used for performing mass spectrum detection to charged molecules and atoms in a sample microcell; and a spectral detection system is used for performing microcell spectrum detection to focal spot excitation spectrums (Raman spectrum and induced breakdown spectrum) of a differential confocal microscopy system, thereby achieving high-spatial discrimination and high-sensitivity imaging and detection of complete component information and configuration parameters of the sample microcell. The invention achieves advantage complement and structure and function fusion of laser poly-spectrum component imaging detection (mass spectrum, Raman spectrum and laser-induced breakdown spectrum). The method and the device have wide application prospect in the fields of biology, physical chemistry, micro-fabrication and nano-fabrication and the like.
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY

Liquid injection type super smooth surface and laser precision micro-fabrication method thereof

The invention relates to a liquid injection type super smooth surface and a laser precision micro-fabrication method thereof, and belongs to the technical field of functional materials. The liquid injection type super smooth surface takes a metal as a substrate; firstly, a micro-nano composite structure is prepared on the metal surface by means of laser etching; after that, a super-hydrophobic surface is obtained by baking, and then injected liquid covers the super-hydrophobic surface to obtain the liquid injection type super smooth surface. Test droplets include water droplets, acid solutions, alkali solutions, lake water, sea water, serum, glycerin and ketchup. The liquid injection type super smooth surface provided by the invention has very small frictional resistance, and can very easily slide off the surface and reduce the retention time and probability of the water droplets and other test liquid on the surface. The laser precision micro-fabrication method of the liquid injection type super smooth surface provided by the invention adopts the laser precision machining technology to prepare the micro-nano composite structure on the metal surface, the technological process is simple and easy to operate, no other chemical additives are needed, and there is no toxic side effect and pollution, so that the laser precision micro-fabrication method is suitable for large-scale and mass production.
Owner:CHANGCHUN UNIV OF SCI & TECH

Laser confocal LIBS, Raman spectrum-mass spectrum imaging method and Raman spectrum-mass spectrum imaging device

InactiveCN105136674ARealizing high-spatial mass spectrometry microscopy imagingImplement focus detectionRaman scatteringSpectroscopie ramanLaser-induced breakdown spectroscopy
The invention relates to a laser confocal LIBS, a Raman spectrum-mass spectrum imaging method and a Raman spectrum-mass spectrum imaging device and belongs to the technical fields of confocal microscopy imaging, mass spectrum imaging and spectral measurement. In the invention, the confocal microscopy imaging technology is combined with a spectrum and mass spectrum detection technology; a high-spatial-discrimination confocal system is used for axially focusing and imaging a sample; a mass spectrum detection system is used for performing mass spectrum detection to charged molecules and atoms in a sample microcell; and a spectral detection system is used for performing microcell spectrum detection to focal spot excitation spectrums (Raman spectrum and induced breakdown spectrum) of a confocal microscopy system, thereby achieving high-spatial discrimination and high-sensitivity imaging and detection of complete component information and configuration parameters of the sample microcell. The invention achieves advantage complement and structure and function fusion of laser poly-spectrum component imaging detection (mass spectrum, Raman spectrum and laser-induced breakdown spectrum). The method and the device have wide application prospect in the fields of biology, physical chemistry, micro-fabrication and nano-fabrication and the like.
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY

Flexible three-dimensional single-cell targeted cultivating chip and controllable preparation method thereof

InactiveCN103122311ARealization of positioning trainingLong-term stable pattern propertiesTissue/virus culture apparatusMicro fabricationMicro column
The invention discloses a flexible three-dimensional single-cell targeted cultivating chip achieved on the basis of a micro-fabrication technique, and belongs to the field of a biological micro-electromechanical (Bio-MEMS) system; the chip includes cell cultivation micro-wells 1 which are distributed in an array; and a micro-column array 3 is included at the bottom part of each cell cultivation micro-well 1. The preparation method of the chip is finished by an MEMS (micro-electromechanical system) technology and a duplicate molding technique; the preparation method comprises the processes of mixing a PDMS (polydimethylsiloxane) prepolymer with a cross-linking agent, pouring the PDMS on a silicon template; curing by the PDMS, and stripping the PDMS. The flexible three-dimensional single-cell targeted cultivating chip has the beneficial effects that a cell 2 to be cultivated is limited into each micro-well by controlling the sizes of the cell cultivation micro-wells 1; the cell targeted cultivation is achieved; meanwhile, the depth of each micro-well is greater than that of a micro-column in each micro-well; and three-dimensional cultivation of the cell is achieved; a pattern base is directly built on the surface of the PDMS in chip preparation; the chip can be used for cell cultivation without any physical or chemical decoration; and the flexible three-dimensional single-cell targeted cultivating chip has the characteristics of long-term stable and reliable pattern property and pattern structure. The PDMS material has good translucency and is convenient to observe the cell.
Owner:NORTHWESTERN POLYTECHNICAL UNIV
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