Erding granule extraction process for improving transfer rate of aesculetin

The invention relates to a technology of qinpirin and extraction process, which is applied in the field of extraction process of Erding granules, which can solve the problems of waste of medicinal material resources and low extraction rate, and achieve the effects of improving the transfer rate, making full use of medicinal material resources, and reducing production costs.

Pending Publication Date: 2021-03-16
ZHENGZHOU BARY ANIMAL PHARMA
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Problems solved by technology

[0004] Flavonoids are flavonoids, the chemical name is 6,7-dihydroxycoumarin, and its structure is coumarin-like esculin, soluble in hot ethanol, methanol and dilute alkali solution, slightly soluble in water and ethanol , ethyl acetate, insoluble in ether and chloroform, the traditional extraction process generally uses water as the extraction solvent, but the general extraction rate is not high, resulting in a waste of medicinal resources

Method used

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  • Erding granule extraction process for improving transfer rate of aesculetin
  • Erding granule extraction process for improving transfer rate of aesculetin
  • Erding granule extraction process for improving transfer rate of aesculetin

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Embodiment 1

[0016] 1.1 Instruments and reagents: LC-1260 high performance liquid chromatography (Agilent, USA); KQ5200B ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); GZX-9140MBE electric blast drying oven (Shanghai Boxun Industrial Co., Ltd. Medical Equipment Factory) 1 / 100,000 analytical balance (MS205DU, Mettler-Toledo); TD5Z low-speed centrifuge (Hunan Kaida Scientific Instrument Co., Ltd); China National Institutes for Food and Drug Control; Viola chinensis, lobelia, dandelion, and Radix Radix were purchased from the medicinal material market in Yuzhou, Henan, and all of them conformed to the relevant provisions of the 2015 edition of "Chinese Pharmacopoeia" under the item of the medicinal material.

[0017] 1.2 Method

[0018] 1.2.1 Preparation of the reference substance solution: Accurately weigh 9.30 mg of the reference substance of fencetin, put it in a 100mL measuring bottle, add methanol to dissolve and adjust the volume to the mark, and shake well to obtain a 0....

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Abstract

The invention belongs to the technical field of traditional Chinese medicine extraction, and relates to an Erding granule extraction process for improving the transfer rate of aesculetin, which comprises the following steps of: proportionally taking four medicinal materials including herba violae, herba lobeliae chinensis, herba taraxaci and radix isatidis, adding 10-12 times of aqueous alkali with the pH value of 9-10, heating and decocting for 1-3 times, each time for 1-2 hours, filtering, merging filtrate, concentrating, centrifuging and preparing 1g / mL medicine liquid from the supernatant.According to the method, the Erding granules are extracted by adopting the aqueous alkali for the first time, so that the transfer rate of aesculetin is greatly increased, medicinal material resources can be fully utilized, and the production cost is reduced.

Description

technical field [0001] The invention belongs to the technical field of extraction of traditional Chinese medicines, and relates to an extraction process of diding granules for improving the transfer rate of acetaminophen. Background technique [0002] Erding Granules is a commonly used traditional Chinese medicine preparation recorded in the 2015 edition of "Chinese Pharmacopoeia". Treatment of hot furuncle and carbuncle poison, damp-heat jaundice, exogenous wind-heat, sore throat, wind-heat and fire eyes caused by excessive heat and poison. [0003] In the prescription of Erding Granules, Zihuadiding and Dandelion (Huanghuadiding) are bitter and cold, clear away heat and detoxify, and eliminate carbuncle as the monarch drug; Comes out with urination, and also has the effect of reducing swelling and detoxification. Combination of various medicines, the strength is specific and strong, and it is actually a heavy medicine for clearing away heat and detoxifying. Studies have...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/16A61K31/366A61K36/86A61K36/34A61K36/288A61K36/195A61K36/315
CPCC07D311/16A61K31/366A61K2236/331A61K36/86A61K36/34A61K36/288A61K36/195A61K36/315A61K2300/00
Inventor 康玉霞崔小七陈长青周衡赵静丁佳丽
Owner ZHENGZHOU BARY ANIMAL PHARMA
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