Sambucus chinensis herb extract for treating gout and preparation method thereof

A technology of elderberry and extract, which is applied in the field of elderberry extract and its preparation for the treatment of gout, can solve the problems of analyzing the mechanism of treatment of traditional Chinese medicine preparations, it is difficult to determine the anti-gout activity of elderberry, and there is no detailed introduction of elderberry, etc. Achieve the effects of being conducive to large-scale production, simple and easy preparation methods, and convenient and easy-to-obtain sources

Pending Publication Date: 2021-03-26
广西云康健健康管理有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above two patent (application) documents, it is mentioned that elderberry can be used in the traditional Chinese medicine preparation for the treatment of gout, but in the documents, it is not introduced in detail what effect elderberry plays in its medicine, and there is no response to the obtained Analysis of the treatment mechanism of traditional Chinese medicine preparations, it is difficult to determine whether

Method used

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  • Sambucus chinensis herb extract for treating gout and preparation method thereof
  • Sambucus chinensis herb extract for treating gout and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 elderberry aqueous extract

[0026] Crush elderberry into fine powder, take 1kg of elderberry fine powder, add 6L of distilled water to soak for 60min, then heat to 80°C for extraction for 60min, filter, and collect the filtrate; add 6L of distilled water to the residue, heat to 80°C for 60min, filter, and collect the filtrate Add 6L of distilled water to the filter residue and heat to 80°C for extraction for 60 minutes, filter and collect the filtrate; combine the three extracts, concentrate to 1.0-1.2g / mL, and obtain the product.

Embodiment 2

[0027] Embodiment 2 Preparation of Elderberry Water Extract

[0028] Crush elderberry into fine powder, take 1kg of elderberry fine powder, add 7L of distilled water to soak for 60min, then heat to 90°C for extraction for 60min, filter, and collect the filtrate; add 7L of distilled water to the residue, heat to 90°C for 60min, filter, and collect the filtrate Add 7L of distilled water to the filter residue and heat to 90°C to extract for 60 minutes, filter, and collect the filtrate; combine the three extracts, concentrate to 1.0-1.2g / mL, and obtain the product.

Embodiment 3

[0029] Embodiment 3 Preparation of Elderberry Water Extract

[0030] Crush elderberry into fine powder, take 1kg of elderberry fine powder, add 8L of distilled water to soak for 60min, then heat to 98°C for extraction for 60min, filter, and collect the filtrate; add 8L of distilled water to the residue, heat to 98°C for 60min, filter, and collect the filtrate Add 8L of distilled water to the filter residue and heat to 98°C to extract for 60 minutes, filter, and collect the filtrate; combine the three extracts, concentrate to 1.0-1.2g / mL, and obtain the product.

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Abstract

The invention discloses a sambucus chinensis herb extract for treating gout and a preparation method thereof. Sambucus chinensis herb is herb of caprifoliaceae sambucus chinensis. The sambucus chinensis herb extract is an ethanol elution part of a sambucus chinensis herb aqueous extract. An extraction method comprises the following steps of crushing the sambucus chinensis herb into fine powder, adding a proper amount of water, performing heating extraction for 2-4 times, collecting an extraction solution, and concentrating the extraction solution to be 1.0-1.2 g/m; carrying out column chromatography separation on a concentrated solution by adopting a silica gel chromatographic column, carrying out gradient elution by taking ethanol with different concentrations as a mobile phase, collecting each eluent, and performing concentrating to obtain extractum. The sambucus chinensis herb extract is simple in preparation method and low in cost, and the obtained sambucus chinensis herb extract is good in medicine curative effect and high in patent medicine economic benefit when being applied to preparation of medicines for treating/preventing gout and related diseases thereof or medicines with the uric acid regulating function.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to an elderberry extract for treating gout and a preparation method thereof. Background technique [0002] Gout is a group of metabolic diseases caused by the excessive production of uric acid due to purine metabolism disorder and / or the decrease of uric acid excretion, which leads to the increase of uric acid level and the formation of uric acid crystals deposited in joints, soft tissues, and kidneys. Uric acid is the terminal metabolite of human purine compounds, and purine metabolic disorders lead to hyperuricemia (HUA). Hyperuricemia is generally considered to be a sign of gout, and according to statistics, about 5-12% of patients with hyperuricemia will eventually develop gout. Hyperuricemia refers to the state of normal purine diet, the fasting blood uric acid level on two different days is higher than 420 μmol / L for men and higher than 360 μm...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P19/06A61P29/00A61P19/08A61P1/16
CPCA61K36/48A61K2236/15A61K2236/331A61K2236/53A61K2236/55A61P1/16A61P19/06A61P19/08A61P29/00
Inventor 刘战华周军卢明全张竺英曾燕冬卢玉杨李品
Owner 广西云康健健康管理有限公司
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