Dimetridazole eutectic and preparation method and application thereof

A technology of demenidazole and co-crystal, which is applied in the field of demenidazole co-crystal and its preparation, can solve the problems of undisclosed preparation methods of demenidazole co-crystal drug, and achieve improved bioavailability, taste improvement, good reproducibility

Active Publication Date: 2021-04-02
HEBEI AGRICULTURAL UNIV.
2 Cites 0 Cited by

AI-Extracted Technical Summary

Problems solved by technology

At present, there is no disclosure of any demetronidazole...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Abstract

The invention relates to the technical field of pharmacy, and particularly discloses a dimetridazole eutectic and a preparation method and application thereof. The dimetridazole eutectic takes dimetridazole as an active ingredient and saccharin as a eutectic forming body, and the dimetridazole and the saccharin are combined through hydrogen bond acting force to form the eutectic. Compared with pure dimetridazole, a special three-dimensional structure formed by dimetridazole and saccharin has more stable physical properties, the water solubility of dimetridazole is obviously improved under thesame condition, and the bioavailability of dimetridazole drugs is greatly improved. Compared with dimetridazole, the taste of the dimetridazole eutectic is greatly improved, and the original bitter taste of dimetridazole is eliminated.

Application Domain

Antibacterial agentsOrganic active ingredients +2

Technology Topic

Aqueous solubilitySaccharin +9

Image

  • Dimetridazole eutectic and preparation method and application thereof
  • Dimetridazole eutectic and preparation method and application thereof
  • Dimetridazole eutectic and preparation method and application thereof

Examples

  • Experimental program(4)
  • Effect test(1)

Example Embodiment

[0040]Example 1
[0041]A genitonazole coexisole, with generic nitric acid as an active ingredient, with saccharin as a eutectic formation, and both form a co-crystal by hydrogen bonding force.
[0042]The preparation method of the above-mentioned nitricatozole copies is: 38.5 mg of genitazole is added to 1 ml of water, then 50 mg of saccharin, stirring at 25 ° C, 200R / min, stirring under stirring 24 h, using medium speed filter paper, will The obtained solid powder was dried to constant weight in an oven at 50 ° C, i.e., gave a genidazole coexisole.

Example Embodiment

[0043]Example 2
[0044]A genitonazole coexisole, with generic nitric acid as an active ingredient, with saccharin as a eutectic formation, and both form a co-crystal by hydrogen bonding force.
[0045]The preparation method of the above-mentioned nitricazole copies is: 77 mg of genitazole is added to 2 ml of water, then 100 mg of sugar, stirred at 45 ° C, 400r / min, stirred under stirring, and filtered by medium speed filter paper, will be obtained The solid powder is dried in an oven at 45 ° C to a constant weight, i.e., a genidazole coexisole.

Example Embodiment

[0046]Example 3
[0047]A genitonazole coexisole, with generic nitric acid as an active ingredient, with saccharin as a eutectic formation, and both form a co-crystal by hydrogen bonding force.
[0048]The preparation method of the above-mentioned nitrazole copies is: 115.5 mg of genitazole is added to 3 ml of water, then 150 mg of sugar, stirred at 30 ° C, 300r / min, stirred for 48 h, using medium speed filter paper, will The obtained solid powder was dried in an oven at 55 ° C to a constant weight, i.e., gave a genidazole copser.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Melting point153.0°C
tensileMPa
Particle sizePa
strength10

Description & Claims & Application Information

We can also present the details of the Description, Claims and Application information to help users get a comprehensive understanding of the technical details of the patent, such as background art, summary of invention, brief description of drawings, description of embodiments, and other original content. On the other hand, users can also determine the specific scope of protection of the technology through the list of claims; as well as understand the changes in the life cycle of the technology with the presentation of the patent timeline. Login to view more.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Similar technology patents

Positive rhythm reservoir combined polymer type profile control agent and using method thereof

InactiveCN107236526ASealed firmlyStable physical propertiesCleaning apparatusDrilling compositionWater cycleBlocking layer
Owner:DALIAN DONGYOU RUIJIA PETROLEUM TECH CO LTD

Anti-reflective glass with ultra-large panel and preparation method thereof

InactiveCN107640910AStable physical propertiesSolve the requestTemperature resistanceSilicon nitride
Owner:SHANGHAI NORTHGLASS COATING TECH IND

Novel left and right fog lamp decorative cover body checking fixture

PendingCN107966083AGood adaptabilityStable physical propertiesMechanical measuring arrangementsEngineeringFunctional module
Owner:NINGBO RANDY AUTOMOBILE PARTS IND

Negative liquid crystal composition containing dibenzofuran compound and application thereof

PendingCN114032107AChemically stableStable physical propertiesLiquid crystal compositionsNon-linear opticsLiquid Crystalline MaterialsDielectric anisotropy
Owner:重庆汉朗精工科技有限公司

Method of using polyethylene imine to extract and separate phenolic substances from coal tar

ActiveCN108002985AStable physical propertiesSimple processOrganic chemistryOrganic compound preparationChemistryBoiling point
Owner:WUHAN INSTITUTE OF TECHNOLOGY

Classification and recommendation of technical efficacy words

  • Improve water solubility
  • Stable physical properties

Selectively hydrogenating catalyst and preparation method thereof

ActiveCN101433845AStable physical propertiesActiveMetal/metal-oxides/metal-hydroxide catalystsRefining by selective hydrogenationPalladiumMetal
Owner:PETROCHINA CO LTD

Preparation for PRRSV-N-IgY antibody and application thereof in detecting PRRSV

InactiveCN101717446AStable physical propertiesReduce the rate of false positivesEgg immunoglobulinsImmunoglobulins against virusesAntigenGlobulin
Owner:ZHEJIANG UNIV

Gas metastable atom beam generation device adopting fluid cooling

InactiveCN106068054AStable temperatureStable physical propertiesMasersAcceleratorsEngineeringPre cooling
Owner:PLA PEOPLES LIBERATION ARMY OF CHINA STRATEGIC SUPPORT FORCE AEROSPACE ENG UNIV

High-performance capacitor film

InactiveCN104140592AStable physical propertiesGood mechanical strengthPolypropylenePOLYETHYLENE WAX
Owner:宁国市裕华电器有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2023 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap