Dimetridazole eutectic and preparation method and application thereof
A technology of demenidazole and co-crystal, which is applied in the field of demenidazole co-crystal and its preparation, can solve the problems of undisclosed preparation methods of demenidazole co-crystal drug, and achieve improved bioavailability, taste improvement, good reproducibility
Active Publication Date: 2021-04-02
HEBEI AGRICULTURAL UNIV.
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The invention relates to the technical field of pharmacy, and particularly discloses a dimetridazole eutectic and a preparation method and application thereof. The dimetridazole eutectic takes dimetridazole as an active ingredient and saccharin as a eutectic forming body, and the dimetridazole and the saccharin are combined through hydrogen bond acting force to form the eutectic. Compared with pure dimetridazole, a special three-dimensional structure formed by dimetridazole and saccharin has more stable physical properties, the water solubility of dimetridazole is obviously improved under thesame condition, and the bioavailability of dimetridazole drugs is greatly improved. Compared with dimetridazole, the taste of the dimetridazole eutectic is greatly improved, and the original bitter taste of dimetridazole is eliminated.
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Property | Measurement | Unit |
Melting point | 153.0 | °C |
tensile | MPa | |
Particle size | Pa | |
strength | 10 |
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