Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dimetridazole eutectic and preparation method and application thereof

A technology of demenidazole and co-crystal, which is applied in the field of demenidazole co-crystal and its preparation, can solve the problems of undisclosed preparation methods of demenidazole co-crystal drug, and achieve improved bioavailability, taste improvement, good reproducibility

Active Publication Date: 2021-04-02
HEBEI AGRICULTURAL UNIV.
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no disclosure of any demetronidazole co-crystal drug and its corresponding preparation method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dimetridazole eutectic and preparation method and application thereof
  • Dimetridazole eutectic and preparation method and application thereof
  • Dimetridazole eutectic and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A dimenidazole co-crystal, which uses dimenidazole as an active ingredient and saccharin as a co-crystal former, and the two are combined by hydrogen bonds to form a co-crystal.

[0042] The preparation method of the above-mentioned dimenidazole co-crystal is as follows: add 38.5 mg of dimenidazole into 1 mL of water, then add 50 mg of saccharin, stir for 24 hours at 25°C and 200 r / min, and filter with a medium-speed filter paper. The obtained solid powder was dried in an oven at 50° C. to a constant weight to obtain the dimetridazole co-crystal.

Embodiment 2

[0044]A dimenidazole co-crystal, which uses dimenidazole as an active ingredient and saccharin as a co-crystal former, and the two are combined by hydrogen bonds to form a co-crystal.

[0045] The preparation method of the above-mentioned dimenidazole co-crystal is as follows: add 77 mg of dimenidazole into 2 mL of water, then add 100 mg of saccharin, stir at 45°C and 400 r / min for 36 hours, and filter with medium-speed filter paper to obtain The solid powder was dried in an oven at 45°C to constant weight to obtain the dimetridazole co-crystal.

Embodiment 3

[0047] A dimenidazole co-crystal, which uses dimenidazole as an active ingredient and saccharin as a co-crystal former, and the two are combined by hydrogen bonds to form a co-crystal.

[0048] The preparation method of the above-mentioned dimenidazole co-crystal is as follows: add 115.5 mg of dimenidazole into 3 mL of water, then add 150 mg of saccharin, stir at 30°C and 300 r / min for 48 hours, filter with medium-speed filter paper, and The obtained solid powder was dried in an oven at 55° C. to a constant weight to obtain the dimetridazole co-crystal.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Melting pointaaaaaaaaaa
Login to View More

Abstract

The invention relates to the technical field of pharmacy, and particularly discloses a dimetridazole eutectic and a preparation method and application thereof. The dimetridazole eutectic takes dimetridazole as an active ingredient and saccharin as a eutectic forming body, and the dimetridazole and the saccharin are combined through hydrogen bond acting force to form the eutectic. Compared with pure dimetridazole, a special three-dimensional structure formed by dimetridazole and saccharin has more stable physical properties, the water solubility of dimetridazole is obviously improved under thesame condition, and the bioavailability of dimetridazole drugs is greatly improved. Compared with dimetridazole, the taste of the dimetridazole eutectic is greatly improved, and the original bitter taste of dimetridazole is eliminated.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a dimetridazole co-crystal and a preparation method and application thereof. Background technique [0002] Dimetronidazole (DMZ) is a nitroimidazole derivative, which is used in veterinary clinics and can effectively treat bacterial and protozoan infections in poultry, pigs, etc. medicine. Dimenidazole itself is light yellow, and the color tends to turn dark green after exposure to light. The stability is poor, the molecule is weakly alkaline, difficult to dissolve in water, and the bioavailability is low. [0003] The efficacy of oral solid dosage forms largely depends on the solid form of the active pharmaceutical ingredient (API). Active pharmaceutical ingredients have different solid forms and often have different physicochemical properties (solubility, stability, and in vivo bioavailability). The US FDA (Food and Drug Administration) biological classification system (bio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D233/92C07D275/06A61K31/4164A61P31/04A61P33/02
CPCC07D233/92C07D275/06A61P31/04A61P33/02C07B2200/13
Inventor 赵兴华何欣李金辉
Owner HEBEI AGRICULTURAL UNIV.
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com