Dimetridazole eutectic and preparation method and application thereof

A technology of demenidazole and co-crystal, which is applied in the field of demenidazole co-crystal and its preparation, can solve the problems of undisclosed preparation methods of demenidazole co-crystal drug, and achieve improved bioavailability, taste improvement, good reproducibility

Active Publication Date: 2021-04-02
HEBEI AGRICULTURAL UNIV.
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AI-Extracted Technical Summary

Problems solved by technology

At present, there is no disclosure of any demetronidazole...
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Abstract

The invention relates to the technical field of pharmacy, and particularly discloses a dimetridazole eutectic and a preparation method and application thereof. The dimetridazole eutectic takes dimetridazole as an active ingredient and saccharin as a eutectic forming body, and the dimetridazole and the saccharin are combined through hydrogen bond acting force to form the eutectic. Compared with pure dimetridazole, a special three-dimensional structure formed by dimetridazole and saccharin has more stable physical properties, the water solubility of dimetridazole is obviously improved under thesame condition, and the bioavailability of dimetridazole drugs is greatly improved. Compared with dimetridazole, the taste of the dimetridazole eutectic is greatly improved, and the original bitter taste of dimetridazole is eliminated.

Application Domain

Technology Topic

Aqueous solubilitySaccharin +9

Image

  • Dimetridazole eutectic and preparation method and application thereof
  • Dimetridazole eutectic and preparation method and application thereof
  • Dimetridazole eutectic and preparation method and application thereof

Examples

  • Experimental program(4)
  • Effect test(1)

Example Embodiment

[0040]Example 1
[0041]A genitonazole coexisole, with generic nitric acid as an active ingredient, with saccharin as a eutectic formation, and both form a co-crystal by hydrogen bonding force.
[0042]The preparation method of the above-mentioned nitricatozole copies is: 38.5 mg of genitazole is added to 1 ml of water, then 50 mg of saccharin, stirring at 25 ° C, 200R / min, stirring under stirring 24 h, using medium speed filter paper, will The obtained solid powder was dried to constant weight in an oven at 50 ° C, i.e., gave a genidazole coexisole.

Example Embodiment

[0043]Example 2
[0044]A genitonazole coexisole, with generic nitric acid as an active ingredient, with saccharin as a eutectic formation, and both form a co-crystal by hydrogen bonding force.
[0045]The preparation method of the above-mentioned nitricazole copies is: 77 mg of genitazole is added to 2 ml of water, then 100 mg of sugar, stirred at 45 ° C, 400r / min, stirred under stirring, and filtered by medium speed filter paper, will be obtained The solid powder is dried in an oven at 45 ° C to a constant weight, i.e., a genidazole coexisole.

Example Embodiment

[0046]Example 3
[0047]A genitonazole coexisole, with generic nitric acid as an active ingredient, with saccharin as a eutectic formation, and both form a co-crystal by hydrogen bonding force.
[0048]The preparation method of the above-mentioned nitrazole copies is: 115.5 mg of genitazole is added to 3 ml of water, then 150 mg of sugar, stirred at 30 ° C, 300r / min, stirred for 48 h, using medium speed filter paper, will The obtained solid powder was dried in an oven at 55 ° C to a constant weight, i.e., gave a genidazole copser.
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PUM

PropertyMeasurementUnit
Melting point153.0°C
tensileMPa
Particle sizePa
strength10

Description & Claims & Application Information

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