Dimetridazole eutectic and preparation method and application thereof

A technology of demenidazole and co-crystal, which is applied in the field of demenidazole co-crystal and its preparation, can solve the problems of undisclosed preparation methods of demenidazole co-crystal drug, and achieve improved bioavailability, taste improvement, good reproducibility

Active Publication Date: 2021-04-02
HEBEI AGRICULTURAL UNIV.
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no disclosure of any demetronidazole

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dimetridazole eutectic and preparation method and application thereof
  • Dimetridazole eutectic and preparation method and application thereof
  • Dimetridazole eutectic and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0040]Example 1

[0041]A genitonazole coexisole, with generic nitric acid as an active ingredient, with saccharin as a eutectic formation, and both form a co-crystal by hydrogen bonding force.

[0042]The preparation method of the above-mentioned nitricatozole copies is: 38.5 mg of genitazole is added to 1 ml of water, then 50 mg of saccharin, stirring at 25 ° C, 200R / min, stirring under stirring 24 h, using medium speed filter paper, will The obtained solid powder was dried to constant weight in an oven at 50 ° C, i.e., gave a genidazole coexisole.

Example Embodiment

[0043]Example 2

[0044]A genitonazole coexisole, with generic nitric acid as an active ingredient, with saccharin as a eutectic formation, and both form a co-crystal by hydrogen bonding force.

[0045]The preparation method of the above-mentioned nitricazole copies is: 77 mg of genitazole is added to 2 ml of water, then 100 mg of sugar, stirred at 45 ° C, 400r / min, stirred under stirring, and filtered by medium speed filter paper, will be obtained The solid powder is dried in an oven at 45 ° C to a constant weight, i.e., a genidazole coexisole.

Example Embodiment

[0046]Example 3

[0047]A genitonazole coexisole, with generic nitric acid as an active ingredient, with saccharin as a eutectic formation, and both form a co-crystal by hydrogen bonding force.

[0048]The preparation method of the above-mentioned nitrazole copies is: 115.5 mg of genitazole is added to 3 ml of water, then 150 mg of sugar, stirred at 30 ° C, 300r / min, stirred for 48 h, using medium speed filter paper, will The obtained solid powder was dried in an oven at 55 ° C to a constant weight, i.e., gave a genidazole copser.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Melting pointaaaaaaaaaa
Login to view more

Abstract

The invention relates to the technical field of pharmacy, and particularly discloses a dimetridazole eutectic and a preparation method and application thereof. The dimetridazole eutectic takes dimetridazole as an active ingredient and saccharin as a eutectic forming body, and the dimetridazole and the saccharin are combined through hydrogen bond acting force to form the eutectic. Compared with pure dimetridazole, a special three-dimensional structure formed by dimetridazole and saccharin has more stable physical properties, the water solubility of dimetridazole is obviously improved under thesame condition, and the bioavailability of dimetridazole drugs is greatly improved. Compared with dimetridazole, the taste of the dimetridazole eutectic is greatly improved, and the original bitter taste of dimetridazole is eliminated.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a dimetridazole co-crystal and a preparation method and application thereof. Background technique [0002] Dimetronidazole (DMZ) is a nitroimidazole derivative, which is used in veterinary clinics and can effectively treat bacterial and protozoan infections in poultry, pigs, etc. medicine. Dimenidazole itself is light yellow, and the color tends to turn dark green after exposure to light. The stability is poor, the molecule is weakly alkaline, difficult to dissolve in water, and the bioavailability is low. [0003] The efficacy of oral solid dosage forms largely depends on the solid form of the active pharmaceutical ingredient (API). Active pharmaceutical ingredients have different solid forms and often have different physicochemical properties (solubility, stability, and in vivo bioavailability). The US FDA (Food and Drug Administration) biological classification system (bio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D233/92C07D275/06A61K31/4164A61P31/04A61P33/02
CPCC07D233/92C07D275/06A61P31/04A61P33/02C07B2200/13
Inventor 赵兴华何欣李金辉
Owner HEBEI AGRICULTURAL UNIV.
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap