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Solid pharmaceutical composition containing metformin and vildagliptin

A technology of metformin and composition, applied in the field of solid pharmaceutical compositions containing metformin and vildagliptin

Inactive Publication Date: 2021-04-23
江苏宇锐医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] But the medicine that only uses above-mentioned two components to carry out the combination system still has a lot of side effects, therefore, it is necessary to develop a kind of solid pharmaceutical composition containing metformin and vildagliptin, can suppress the complication of diabetes while reducing blood sugar and controlling blood sugar disease

Method used

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  • Solid pharmaceutical composition containing metformin and vildagliptin
  • Solid pharmaceutical composition containing metformin and vildagliptin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: The solid pharmaceutical composition containing metformin and vildagliptin includes metformin, vildagliptin, rosiglitazone and B vitamins, wherein the mass parts of metformin are: 1 part; vildagliptin 20 parts by mass; 1 part by mass of rosiglitazone; 1 part by mass of B vitamins B6; 20 parts by carrier; 4 parts of polyethylene glycol and 6 parts of povidone Part; Ethyl cellulose is 10 parts; Described polyethylene glycol is the composition of polyethylene glycol 2000 and polyethylene glycol 4000; Described povidone is the composition of povidone K30 and povidone K90; The ethyl cellulose is a composition of ethyl cellulose 7cp and ethyl cellulose 45cp; wherein the mass ratio of polyethylene glycol 2000 and polyethylene glycol 4000 is 1:1; the povidone K30 The mass ratio to povidone K90 is 1:2; the mass ratio of ethyl cellulose 7cp to ethyl cellulose 45cp is 1.5:2.

[0023]Preparation process: Weigh the raw materials according to the above ratio (wherein t...

Embodiment 2

[0024] Embodiment 2: The solid pharmaceutical composition containing metformin and vildagliptin includes metformin, vildagliptin, rosiglitazone and B vitamins, wherein the mass parts of metformin are: 1.5 parts; vildagliptin 25.5 parts by mass; 1 part by mass of rosiglitazone; 1.5 parts by mass of B vitamins B6; 25 parts of carrier; 4 parts of polyethylene glycol and 6 parts of povidone Part; Ethyl cellulose is 10 parts; Described polyethylene glycol is the composition of polyethylene glycol 2000 and polyethylene glycol 4000; Described povidone is the composition of povidone K30 and povidone K90; The ethyl cellulose is a composition of ethyl cellulose 7cp and ethyl cellulose 45cp; wherein the mass ratio of polyethylene glycol 2000 and polyethylene glycol 4000 is 1:1; the povidone K30 The mass ratio to povidone K90 is 1:2; the mass ratio of ethyl cellulose 7cp to ethyl cellulose 45cp is 1.5:2.

[0025] The preparation method is the same as in Example 1.

Embodiment 3

[0026] Example 3: The solid pharmaceutical composition containing metformin and vildagliptin includes metformin, vildagliptin, rosiglitazone and B vitamins, wherein the mass parts of metformin are: 2 parts; vildagliptin 40 parts by mass; 1 part by mass of rosiglitazone; 2 parts by mass of B vitamins B6; 25 parts of carrier; 4 parts of polyethylene glycol and 6 parts of povidone Part; Ethyl cellulose is 10 parts; Described polyethylene glycol is the composition of polyethylene glycol 2000 and polyethylene glycol 4000; Described povidone is the composition of povidone K30 and povidone K90; The ethyl cellulose is a composition of ethyl cellulose 7cp and ethyl cellulose 45cp; wherein the mass ratio of polyethylene glycol 2000 and polyethylene glycol 4000 is 1:1; the povidone K30 The mass ratio to povidone K90 is 1:2; the mass ratio of ethyl cellulose 7cp to ethyl cellulose 45cp is 1.5:2.

[0027] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a solid pharmaceutical composition containing metformin and vildagliptin. The solid pharmaceutical composition containing metformin and vildagliptin comprises the following components in parts by mass: 1-3 parts of the metformin, 15-60 parts of the vildagliptin, 1-3 parts of rosiglitazone and 0.8-2 parts of vitamin B. The solid pharmaceutical composition containing metformin and vildagliptin is a single tablet or a capsule. According to the solid pharmaceutical composition containing metformin and vildagliptin, through scientific combination of three different hypoglycemic drugs, the purposes of mechanism complementation, mutual cooperation, curative effect improvement and reasonable medication are achieved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical compositions, in particular to a solid pharmaceutical composition containing metformin and vildagliptin. Background technique [0002] The incidence of diabetes is still increasing year by year. According to the data provided by the World Health Organization (WHO), the prevalence of diabetes in developed countries has reached 5% to 10%, while in my country it is about 3%. There are 130 million diabetic patients in the world; by 2030, the number of diabetic patients in the world will double that of 2000. It is noteworthy that the prevalence of diabetes is increasing particularly rapidly in developing countries, especially those developing countries that are going from poor to rich. Diabetes is not just a disease of the rich. In areas where the economy and living standards have undergone drastic changes, there is a real danger of diabetes outbreaks. Diabetes in my country is in an explosive...

Claims

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Application Information

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IPC IPC(8): A61K31/155A61K31/40A61K31/4439A61K31/525A61K31/4415A61K31/714A61K31/4188A61K9/22A61K9/20A61K9/48A61K47/10A61K47/32A61K47/38A61P3/10
Inventor 计莹
Owner 江苏宇锐医药科技有限公司
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