Application of water extract of fenxin wood in preparation of medicine for treating ulcerative colitis
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A technique for ulcerative colitis, distraction wood, used in the field of medicine
Active Publication Date: 2022-03-04
中国人民解放军海军特色医学中心
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[0004] At present, there are no reports on the preparation method of the extract of the eucalyptus, the pharmaceutical composition with the extract as the active ingredient, and its application in the medicine for treating ulcerative colitis at home and abroad.
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Embodiment 1
[0037] Example 1: Preparation and component analysis of the water extract of fenugreek
[0038] 1. Preparation of heart wood water extract
[0039] Weigh 1000g of the medicinal material of fenxin, wash it with distilled water, add 10L of distilled water to soak, after soaking for 2h, heat and reflux at 100°C for 1h to extract. The extract was collected, filtered, concentrated to 200mL with a rotary evaporator at 60°C, pre-frozen at -70°C for 6 hours, and vacuum freeze-dried at -50°C for 48 hours to obtain a dark brown water extract of S. 0.82%.
[0040] 2. Composition analysis of the water extract of fenugreek
[0041] The composition of the water extract of the branch wood includes: the total flavonoid content is 33.40±0.88%, the total polysaccharide content is 30.80±2.28%, and the total polyphenol content is 24.62±0.86%.
Embodiment 2
[0042] Example 2: Research on the effect of water extract of fenxinmu on ulcerative colitis in mice
[0043] 1. Animal grouping and dosing regimen
[0044] C57BL / 6 mice, male, 6 weeks old, body weight 20±2g, SPF grade, were purchased from the Animal Center of the Naval Special Medical Center. After the mice were adaptively fed for 5 days, the mice were randomly divided into 4 groups with SPSS software, 10 in each group, respectively, the control group, the model group, the Chinese medicine group (Fanxinmu water extract 500mg / kg), and the positive drug group (Mesalamine 600mg / kg). The model of ulceration was established by DSS induction method: except for the control group, the mice drank 3% DSS solution freely for seven consecutive days. Since the first day of modeling, continuous administration, once a day, for nine consecutive days, the distracted wood group was given 500 mg / kg of the water extract of distracted wood by intragastric administration every day, and the positi...
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Abstract
The invention discloses the application of a water extract of fenugreek in the preparation of medicine for treating ulcerative colitis. The water extract of fenxin wood of the present invention can effectively treat and alleviate the symptoms of ulcerative colitis such as weight loss, diarrhea and blood in the stool, can inhibit the production of inflammatory mediators including TNF-α, IL-6 or IL-1β, and can regulate Intestinal flora composition and promotion of flora recovery, as well as the ability to further protect the mucosal barrier and improve DSS-induced colonic damage. Therefore, the water extract of fenugreek can be used as an effective drug for the treatment of ulcerative colitis, and can be prepared into various dosage forms of drugs or pharmaceutical compositions for the treatment of ulcerative colitis.
Description
technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of water extracts of fenugreek in the preparation of medicines for treating ulcerative colitis. Background technique [0002] Diaphragma juglandis Fructus, also known as walnut coat, nutcracker or walnut diaphragm, etc., is a plant of the genus Juglandaceae. Small flakes of wood. Fenxin wood is flaky, brittle, and easy to break. It usually accounts for 4% to 5% of walnut mass. It is characterized by bitter, astringent, and flat nature. It enters the spleen and kidney meridians. Treatment of various diseases such as spermatorrhea, enuresis, sweating, diarrhea, insomnia and dreaminess. The chemical components contained in Fenxinmu include flavonoids, alkaloids, saponins, sugars and rich phenolic acids. Pharmacological activity studies have shown that Fenxinwood not only has the function of nourishing the kidney, but also has antibacterial and anti-oxidative eff...
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