Anti-adhesion material

An anti-adhesion, polymer technology, applied in the direction of drug combination, bandage, surgery, etc., can solve the problems of fever and inflammation, achieve excellent biodegradability, inhibit the onset of complications, sufficient strength and handling effect

Pending Publication Date: 2022-07-01
TORAY IND INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reason for this is that fever and inflammation due to foreign body reactions may continue to occur due to long-term indwelling

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] A four-branched polyethylene glycol derivative (pentaerythritol polyethylene glycol, SUNBRIGHT (registered trademark) PTE-10T, manufactured by NOF Corporation) (hereinafter, this four-branched polyethylene glycol derivative is referred to as "" Each terminal hydroxyl group of 4PEG") was polymerized with L-lactide (PURASORB (registered trademark) L, manufactured by Corbion) to synthesize a 4PEG-PLLA block copolymer, which was obtained by 1 H-NMR (apparatus name: EX-270, measurement frequency: 400 MHz, measurement solvent: deuterated chloroform, number of counts: 8, measurement temperature: room temperature (about 25°C)), the molecular weight of PTE-10T is assumed to be 10,000 The calculated number average molecular weight was about 40,000. The obtained 4PEG-PLLA had the structures represented by the following general formulae (I) and (II).

[0117] [Chemical 13]

[0118]

[0119] Here, in formula (I), l, m, n and o are each independently an integer of 50 to 60, and ...

Embodiment 2

[0127] Each terminal hydroxyl group of 4PEG (SUNBRIGHT (registered trademark) PTE-10T, manufactured by NOF Corporation) was mixed with L-lactide (PURASORB (registered trademark) L, manufactured by Corbion) and glycolide (PURASORB (registered trademark) G , Corbion Corporation) random polymerization to synthesize 4PEG-PLGA block copolymer, the 4PEG-PLGA block copolymer was determined by measuring under the same conditions as in Example 1 1 The number average molecular weight calculated by H-NMR assuming that the molecular weight of PTE-10T was 10,000 was about 46,000. The ratio of the number of moles of lactic acid to the number of moles of glycolic acid, 1.0, was 4.1. The obtained 4PEG-PLGA block copolymer had structures represented by the following general formulae (I) and (III).

[0128] [Chemical 15]

[0129]

[0130] Here, in formula (I), l, m, n and o are each independently an integer of 50 to 60, and A, B, C and D are each independently a group represented by formul...

Embodiment 3

[0136] Each terminal of an 8-branched polyethylene glycol derivative (SUNBRIGHT (registered trademark) HGEO-50H, manufactured by NOF Corporation) (hereinafter, this 8-branched polyethylene glycol derivative is referred to as "8PEG") The hydroxyl group was polymerized with L-lactide (PURASORB (registered trademark) L, manufactured by Corbion Corporation) to synthesize 8PEG-PLLA block copolymer. The 8PEG-PLLA block copolymer was measured under the same conditions as in Example 1. of 1 The number average molecular weight calculated by H-NMR assuming that the molecular weight of HGEO-50H was 5,000 was about 43,000. The obtained 8PEG-PLLA block copolymer had structures represented by the following general formulae (IV) and (II).

[0137] [Chemical 17]

[0138]

[0139] Here, in formula (IV), p, q, r, s, and t are each independently an integer of 10 to 15, u is 4, and A, B, C, D, and E are each independently and in each repeating unit is a group represented by formula (II),

...

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Abstract

Provided is an anti-adhesion material which has improved tissue adhesion and biodegradability, while having workability for affixing the anti-adhesion material to a biological tissue. The anti-adhesion material comprises a water-soluble support layer which contains a water-soluble polymer and has a thickness of 1-1000 [mu] m, and an anti-adhesion layer which contains a biodegradable polymer and has a thickness of 1-1000 [mu] m, and is characterized in that: the biodegradable polymer has a structure in which a branched polyalkylene glycol and a polyhydroxyalkanoic acid are bonded; the mass ratio of the branched polyalkylene glycol to the total mass is 1-30%, and the branched polyalkylene glycol has 3-8 terminal hydroxyl groups per molecule.

Description

[0001] This application is a divisional application of an application with an application date of September 29, 2017, an application number of "201780059811.0", and an invention title of "anti-adhesion material". technical field [0002] The present invention relates to an anti-adhesion material for suppressing the occurrence of adhesion after a surgical operation or the like. Background technique [0003] During a surgical operation, adhesion may occur between the tissue and surrounding tissue due to damage, bleeding, inflammation, etc. on the surface of the living tissue during the operation. Adhesion is a problem as a postoperative complication because it interferes with the normal movement of the organ. For example, in laparotomy, when the intestinal tract in the abdominal cavity and the abdominal wall or the intestinal tract adhere to each other, the fluidity of the intestinal tract is impaired, and intestinal obstruction (adhesive intestinal obstruction) may occur. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/12A61L31/14C08G63/664
CPCA61L31/06A61L31/14A61L31/042A61L31/048A61L31/125A61L31/148C08G63/664A61L2300/424C08L67/04C08L5/00A61L31/12A61P41/00A61L15/26A61L15/64A61L15/28C08L5/08C08L71/02C08L67/025C08L71/126C08G65/2615A61L31/145
Inventor 斋藤晃广中西惠棚桥一裕荒金彻保地基典铃木爱冈林刚史武冈真司藤枝俊宣石冢祐也大坪真也
Owner TORAY IND INC
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