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Applicator for depositing a layer of adhesive or sealant composition on a biological and/or prosthetic tissue

A technology for applicators and sealants, which is used in devices for applying liquid to surfaces, coatings, medical science, etc., and can solve problems such as difficulty in obtaining adhesive/sealing properties.

Pending Publication Date: 2021-04-23
缇斯佑姆公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in practice, it has proven difficult to obtain reproducible adhesive / seal performance even when using such applicators to apply adhesives or sealants on large vessels

Method used

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  • Applicator for depositing a layer of adhesive or sealant composition on a biological and/or prosthetic tissue
  • Applicator for depositing a layer of adhesive or sealant composition on a biological and/or prosthetic tissue
  • Applicator for depositing a layer of adhesive or sealant composition on a biological and/or prosthetic tissue

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0207] Example 1: Vascular Surgery

[0208] Applicator assemblies according to the invention have been used in revascularization procedures performed in a porcine model. After clamping, a 2-3 cm linear incision was made on the left carotid artery. ePTFE ( Vascular graft, standard wall, 8 mm diameter) was sutured over the incision. The artery has been unclamped and blood leakage from the sutured hole is observed. The vessel is then clamped again. A dispensing device consisting of a 1 ml syringe is connected to the Figure 8 to Figure 10The syringe contains PGSA (poly(glycerol) sebacate acrylic anhydride - US8143042). The suction tube was connected to an external suction device connected to a vacuum line (capable of generating a low pressure of approximately -0.8 bar). The applicator is then used to apply PGSA to the suture. The applicator effectively eliminates blood at the target site, thereby enhancing contact between the PGSA and the underlying tissue. After coverin...

example 2

[0209] Example 2: Urinary Tract Surgery

[0210] A 30 cm abdominal incision was made in the piglet model. Expose the bladder and urethra. The bladder was emptied before a transverse incision was made to separate the bladder and urethra, thereby simulating a radical resection scenario. A Foley catheter (supplied by BBraun) was placed through the urethra and deployed in the bladder. To join the organs, 4 sutures were applied; a small amount of leakage of urine and blood was observed from the anastomotic area. A dispensing device comprising a 1 milliliter (mL) syringe containing PGSAA (poly(glycerol) sebacate acrylic anhydride - WO2016202985) was connected to the applicator according to the invention. The applicator is then connected to an external suction device connected to a vacuum line (capable of generating a low pressure of approximately -0.8 bar). PGSAA was applied over the anastomotic area. By using Gecko's proprietary light-activated pen (Setalum TM ) at 30 seconds...

example 3

[0216] The test was performed in vitro using transverse sections of bovine femurs. The periosteum of the bone was removed and cut into 1.5 cm x 2.5 cm rectangular pieces for easier testing. The bone rectangles were hydrated by immersion in phosphate buffered saline. A dispensing device comprising a 1 milliliter (mL) syringe containing PGSA (poly(glycerol) sebacate acrylic anhydride) was attached to the applicator according to the invention. The applicator is then connected to an external suction device connected to a vacuum line (capable of generating a low pressure of approximately -1.0 to -0.7 bar). First, PGSA was applied over a 1 cm x 1 cm area of ​​the bone with the vacuum turned off, and using Gecko's proprietary light-activated pen (Setalum TM ) for 30 seconds to polymerize. This is performed three times. Then, perform the same procedure with the vacuum on. Adhesive pull measurement was then performed using a mechanical testing machine (supplied by Instron). The l...

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Abstract

The invention relates to an applicator (1) for depositing a layer of adhesive or sealant composition on a target site of a biological and / or prosthetic tissue, the applicator (1) comprising a body (2) having an application face (7) intended to be positioned facing the biological and / or prosthetic tissue, and comprising: - a first outlet opening (9) provided in the application face (7), the first outlet opening (9) being shaped as a slot for allowing the adhesive or sealant composition to flow out of the applicator (1) and to form the layer of adhesive or sealant composition, - a second inlet opening (14) provided in the application face (7), adjacent the first outlet opening (9), for allowing pollutants or undesirable elements to be removed from the target site while depositing the layer of adhesive or sealant composition, wherein the first outlet opening (9) has a first section and the second inlet opening (14) has a second section, the second section being greater than the first section.

Description

technical field [0001] The present invention relates to an applicator for depositing a layer of adhesive or sealant composition on biological and / or prosthetic tissue, and an applicator assembly comprising such an applicator. Background technique [0002] In surgical repair of blood vessels (such as the aorta, femoral, carotid, or coronary arteries or veins), cardiac repair, or urological repair, surgical adhesives or sealants are used as standard methods of achieving hemostasis (such as sutures and staples) aids. Surgical adhesives or sealants may also be used to stop leaks (such as leaks from the brain or spinal cord). Surgical adhesives / sealants are usually deposited as a layer over bleeding or leaking sites to seal holes made by sutures or staples, thereby strengthening the bond between tissues and promoting hemostasis and tissue healing or filling gaps . [0003] However, the performance of the adhesive / sealant depends not only on the properties of the adhesive or se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/00
CPCA61B17/00491A61B2017/005A61B2017/0065A61B2017/00907A61B2017/1107A61B2017/1132A61B2050/314A61B2217/005B05C17/00516A61B17/11A61B50/30A61B2017/00495A61B2017/1135
Inventor 朱利安·拉马佐阿德米格尔·洛佩斯西蒙·梅南尤瑟夫·比亚迪拉玛丽亚·佩雷拉
Owner 缇斯佑姆公司