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Daily compound preparation for treating cold and preparation method thereof

A compound preparation and daily use technology, applied in the field of pharmacy, can solve the problems of reducing the bioavailability of active ingredients, slow onset of effect, and difficult to absorb.

Active Publication Date: 2021-04-30
HUMANWELL PURACAP PHARM WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current commercially available white plus black anti-cold medicine has the disadvantage that the medicine is a tablet, which has a slow onset of action and is not easily absorbed by the body, which reduces the bioavailability of the active ingredient.

Method used

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  • Daily compound preparation for treating cold and preparation method thereof
  • Daily compound preparation for treating cold and preparation method thereof
  • Daily compound preparation for treating cold and preparation method thereof

Examples

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Effect test

preparation example Construction

[0039] The present invention also discloses a preparation method of the daily-use compound preparation for treating common cold, which includes the following preparation steps:

[0040] 1) preparing capsule liquid;

[0041]2) Prepare the content: Take one or two or more mixtures of polyethylene glycol, propylene glycol or glycerin in the formula and heat to 60-80°C; then add a solubilizer and control the stirring speed to 300-1400rpm to stir to the clarified liquid; add acetaminophen and dextromethorphan hydrobromide to the clarified liquid at a stirring speed of 10-25rpm, maintain the temperature at 60-80°C, increase the stirring speed to 500±200rpm and stir At least 1h; then reduce the stirring speed to 10-25rpm, slowly add purified water and phenylephrine hydrochloride in turn, after the addition is complete, increase the stirring speed to 500±200rpm and stir for at least 1h; continue vacuum degassing, nitrogen protection and cooling to 30°C, the content is obtained, and t...

Embodiment

[0051] This embodiment discloses a preparation method of a daily-use compound preparation for treating colds, including the following preparation steps:

[0052] 1) Preparation of capsule liquid: Take the formulated amount of glycerin, sorbitol-sorbitan solution and / or sorbitol solution, and purified water, mix and heat to 60-80°C, add gelatin and continue mixing until the gelatin is completely dissolved; add pigment, and stir evenly Finally, vacuum degassing to obtain a glue solution, the viscosity of the capsule solution is 8000-25000cps, and the capsule solution is stored at 55-65°C for future use.

[0053] Wherein, the capsule liquid is made up of each formula component as shown in the following table 1:

[0054] The formula list of table 1 capsule liquid

[0055]

[0056] 2) Prepare the content: Take one or two or more mixtures of polyethylene glycol, propylene glycol or glycerin in the formula and heat to 60-80°C; then add a solubilizer and control the stirring speed...

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Abstract

The invention discloses a daily compound preparation for treating cold, and particularly belongs to the technical field of pharmaceutics. The daily compound preparation is in a capsule form and comprises a capsule shell and a content in the capsule shell; the content comprises the following chemical raw materials: acetaminophen, dextromethorphan hydrobromide, phenylephrine hydrochloride, a solubilizer, purified water and one or a mixture of two or more of polyethylene glycol, propylene glycol or glycerol. The content is a clarified liquid composition, and the clarified liquid composition is good in stability, high in bioavailability, rapid in effect and capable of well treating clinical cold.

Description

technical field [0001] The invention relates to a cold medicine, which belongs to the technical field of pharmacy, in particular to a daily-use compound preparation for treating colds and a preparation method thereof. Background technique [0002] Cold is a common acute upper respiratory virus infection disease, mostly caused by rhinovirus, parainfluenza virus, respiratory syncytial virus, echovirus, coxsackievirus, coronavirus, adenovirus, etc. Especially in spring and winter, the incidence rate is high. The clinical manifestations are nasal congestion, sneezing, runny nose, fever, cough, headache, sore throat, etc., which make people feel very uncomfortable and will affect normal life in severe cases. [0003] There are many kinds of medicines for treating colds. Western medicines are very popular because of their relatively transparent safety and quick results. Because there are many symptoms of colds, most cold medicines are compound preparations. The compound preparat...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K31/137A61K31/167A61K9/48A61K47/10A61K47/32A61P11/00A61P31/14A61P31/16
CPCA61K9/4866A61K9/4858A61K31/167A61K31/485A61K31/137A61P11/00A61P31/14A61P31/16A61K2300/00
Inventor 丁超沈福星常丹余潇王晨晨
Owner HUMANWELL PURACAP PHARM WUHAN CO LTD
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