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Application of plant essential oil and perfume compound in preparation of sanitary product for inhibiting infective ability of novel corona-virus

A plant essential oil and coronavirus technology, applied in plant growth regulators, botanical equipment and methods, chemicals for biological control, etc., can solve the problem of no specific monomer compound drugs and no coronavirus infection Power and other issues

Inactive Publication Date: 2021-05-04
GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the outbreak of the new coronavirus disease, scientists have studied the new coronavirus from the perspectives of structural biology, immunology, and pharmacology. At present, there is no specific monomer compound drug
However, there are no relevant reports on the application of plant essential oils in sanitary products that reduce the infectivity of coronaviruses.

Method used

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  • Application of plant essential oil and perfume compound in preparation of sanitary product for inhibiting infective ability of novel corona-virus
  • Application of plant essential oil and perfume compound in preparation of sanitary product for inhibiting infective ability of novel corona-virus
  • Application of plant essential oil and perfume compound in preparation of sanitary product for inhibiting infective ability of novel corona-virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Molecular docking of plant essential oils and the main fragrance compounds contained therein with the potential target S protein of the new coronavirus

[0027] Download the 3D structure files of botanical flavor compounds in sdf format from https: / / pubchem.ncbi.nlm.nih.gov / , a website supported by the National Institutes of Health and maintained by the National Center for Biotechnology Information. Then, the 3D conformation was optimized with Avogadro software and saved in pdb format. Finally, assign the relevant charges through Autodock Tools, automatically set the reversible bonds, and export them as pdbqt format files.

[0028] The S protein uses the pdbqt format file downloaded from the new coronavirus drug target structure information sharing platform system of Qingdao State Key Laboratory of Marine Science and Technology Pilot, and runs autodock vina for molecular docking. The docking parameters are as follows:

[0029] center_x=-32.81

[0030] cente...

Embodiment 2

[0063] Embodiment 2: Liquid incense (Essential oil base of the branch and leaf of the leaves of the syringa sativa)

[0064] Quantitatively weigh 1.43% of essential oil and 98.57% of medicinal alcohol, mix and stir evenly to obtain a semi-finished product. The semi-finished product is filtered, filled, and equipped with a hand-pressed spray device to make the finished product.

Embodiment 3

[0065] Example 3: Liquid Fragrance (Turmeric Essential Oil Based)

[0066] Quantitatively weigh 1.33% of turmeric essential oil and 98.67% of medical alcohol, mix and stir evenly to obtain final product.

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Abstract

The invention discloses application of a series of plant essential oil and perfume compounds in preparation of incense products for inhibiting infectivity of novel corona-virus. A computer molecular docking test shows that main compounds contained in the plant essential oil have strong binding force with a potential target S protein of new corona-virus, the binding energy [delta]G of about 210 compounds and the S protein is smaller than or equal to -5.0 kcal / mol, and steric hindrance is formed for binding of ACE2 after the S protein is bound with the compounds. Moreover, the total amount of components with binding energy [delta]G of compounds and S protein being less than or equal to -5.0 kcal / mol in the essential oil is more than 20%, so that the plant essential oil has relatively high potential activity in the aspect of inhibiting SARS-CoV-2 from infecting host cells or self-replication, can reduce or inhibit the infectivity of corona-virus, and is expected to be applied to blocking the corona-virus epidemic situation when being applied to the incense.

Description

technical field [0001] The present invention relates to a new application of plant essential oils, in particular to the application of plant essential oils and fragrance compounds in the preparation of hygienic products that inhibit the infectivity of the novel coronavirus. Background technique [0002] Currently, the outbreak of novel coronavirus infection disease (COVID-19) caused by novel coronavirus (SARS-CoV-2) infection has been listed by the World Health Organization as a public health emergency of international concern. [0003] From 2002 to 2003, the coronavirus SARS-CoV caused severe acute respiratory syndrome (SARS). At that time, more than 80,000 clinically diagnosed cases were reported, and the average case fatality rate was about 11%. SARS-CoV-2 is a virulent virus similar to SARS-CoV, and the source of the virus is still unknown. Unlike SARS-CoV, in addition to severe damage to the respiratory system and intestinal inflammation, SARS-CoV-2 virus infection als...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N65/48A01N65/12A01N65/22A01N65/08A01N65/06A01N25/20A01N25/18A01P1/00
CPCA01N25/18A01N25/20A01N65/00A01N65/06A01N65/08A01N65/12A01N65/22A01N65/48
Inventor 谢运昌蔡爱华霍华珍李典鹏
Owner GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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