Application of spice compounds in preparation of hygienic product for inhibiting infectivity of novel coronavirus

A hygienic product, coronavirus technology, applied in the application field of hygienic products, can solve the problem that there is no specific monomer compound drug and so on

Inactive Publication Date: 2021-06-01
GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the outbreak of the new coronavirus disease, scientists have studied the new coronavirus from the perspectives of structural biology, immunology, and pharmacology. At present...

Method used

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  • Application of spice compounds in preparation of hygienic product for inhibiting infectivity of novel coronavirus
  • Application of spice compounds in preparation of hygienic product for inhibiting infectivity of novel coronavirus
  • Application of spice compounds in preparation of hygienic product for inhibiting infectivity of novel coronavirus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Molecular docking of fragrance compounds with the potential target S protein of 2019-nCoV

[0026] Download the 3D structure files of fragrance compounds in sdf format from the website https: / / pubchem.ncbi.nlm.nih.gov / supported by the National Institutes of Health and maintained by the National Center for Biotechnology Information. The 3D conformation was then optimized with Avogadro software and saved in pdb format. Finally, assign relevant charges through Autodock Tools, automatically set twistable keys, and export to pdbqt format file.

[0027] The S protein adopts the pdbqt format file downloaded from the new coronavirus drug target structure information sharing platform system of the Qingdao State Key Laboratory of Marine Science and Technology, and runs autodock vina for molecular docking. The docking parameters:

[0028] center_x=-32.81

[0029] center_y=25.66

[0030] center_z=4.79

[0031] size_x=23

[0032] size_y=21

[0033] size_z=21

[00...

Embodiment 2

[0044] Example 2: Liquid Fragrance (Isoamyl Salicylate)

[0045] Quantitatively weigh 2.00% of isoamyl salicylate and 98.00% of medical alcohol, mix and stir to obtain.

Embodiment 3

[0046] Example 3: Liquid Fragrance (Bisabolenyl)

[0047] Quantitatively weigh 1.00% of bisabolene and 99.00% of medical alcohol, mix and stir evenly to obtain the obtained product.

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Abstract

The invention discloses application of a series of spice compounds in preparation of a hygienic product for inhibiting infectivity of novel coronavirus. Computer molecular docking tests show that the spice compounds have relatively strong binding capacity to a coronavirus potential target S protein, can reduce or inhibit the infectivity of coronavirus, and are expected to block the coronavirus epidemic situation when being applied to an incense.

Description

technical field [0001] The invention relates to new uses of fragrance compounds, in particular to the application of fragrance compounds in the preparation of sanitary products for inhibiting the infectivity of novel coronavirus. Background technique [0002] At present, the outbreak of novel coronavirus infection (COVID-19) caused by novel coronavirus (SARS-CoV-2) infection has been listed as a public health emergency of international concern by the World Health Organization. [0003] Between 2002 and 2003, the coronavirus SARS-CoV caused severe acute respiratory syndrome (SARS), when more than 80,000 clinically diagnosed cases were reported, with an average case fatality rate of about 11%. SARS-CoV-2 is a potent virus similar to SARS-CoV, the origin of which is still unknown. Different from SARS-CoV, in addition to severe respiratory system damage and intestinal inflammation, SARS-CoV-2 virus infection also shows liver damage, nerve damage, myocardial damage, kidney damag...

Claims

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Application Information

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IPC IPC(8): A01N25/18A01N37/40A01N27/00A01N43/28A01N35/06A01N37/02A01N43/22A01N43/24A01N37/06A01N31/02A01P1/00
CPCA01N25/18A01N37/40A01N27/00A01N43/28A01N35/06A01N37/02A01N43/22A01N43/24A01N37/06A01N31/02
Inventor 谢运昌霍华珍蔡爱华李典鹏
Owner GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI
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