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A kind of isomer of cholanic acid and its detection method and application

A technology for isomers and detection methods, which is applied in measurement devices, material separation, and analysis of materials, etc., can solve the problem that raw material impurities cannot be detected and evaluated accordingly, and achieve the effect of avoiding quality risks.

Active Publication Date: 2022-04-12
SHANDONG INST FOR FOOD & DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the current quality standards for Naoliqing preparations, the detection of pig bile substances usually uses TLC to identify the authenticity of pig gall medicinal materials, and to control the problem of replacing pig gall with beef and sheep gall, but for Naoliqing Whether there are quality risks introduced by composition changes in raw materials such as pig bile, pig bile powder, and pig bile paste in the preparation cannot be tested, and the impurities in the raw materials cannot be detected and evaluated accordingly

Method used

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  • A kind of isomer of cholanic acid and its detection method and application
  • A kind of isomer of cholanic acid and its detection method and application
  • A kind of isomer of cholanic acid and its detection method and application

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Embodiment 1

[0033] The detection of the isomer of embodiment 1 cholanic acid

[0034] Component analysis of pig bile, pig bile powder and pig bile paste

[0035] 1. Instrument, reagent and sample information

[0036] Instrument: Shimadzu LC-20A high performance liquid chromatograph, diode array detector;

[0037] Sartorius CP225D electronic balance

[0038] Reagents: Methanol and phosphoric acid are chromatographically pure, and the rest of the reagents are analytically pure.

[0039] Samples: 13 batches of pig bile powder, 2 batches of pig bile, and 1 batch of pig bile paste were collected through market collection, enterprise provision, and laboratory self-made.

[0040] Reference substances: Niuhuang hyodeoxycholic acid sodium salt (Zhenzhun Biology, batch number: ZS-20025), Niuhuang hyodeoxycholic acid (National Institute for Food and Drug Control, batch number: 111943-201802), taurine chenodeoxychole acid (National Institute for Food and Drug Control, batch number: 110846-201007)...

Embodiment 2

[0058] Example 2 Distribution of by-product 3β-type cholanic acid in pig gallbladder series products and Naoliqing preparations

[0059] The ratio of the peak area of ​​the by-product 3β-type cholanic acid to the sum of the peak areas of the two configurations of cholanic acid is used as the conversion rate evaluation index, that is, the conversion rate=A β / (A α +A β )×100%. In addition, three batches of high-temperature homemade pig gall powder were prepared (boiling and concentrating for 24 hours, drying at 121°C for 8 hours), and the average conversion rate was measured to be 10%, which was used as a limit.

[0060] The results of the analysis of pig bile series products showed that: ① the conversion rate of fresh pig bile collected in the market was lower than 1%; , the highest can reach 75%. It can be seen that the by-product 3β-cholanic acid widely exists in pig bile powder and pig bile ointment medicinal materials.

[0061] Through the investigation of enterprise ...

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Abstract

The invention discloses a cholanic acid isomer and its detection method and application. A new cholanic acid isomer 3β is found in pig bile substances used as the raw material of Naoliqing preparation Type cholanoic acid, the by-product widely exists in pig bile powder and pig bile ointment medicinal materials, and will be transferred into Naoliqing preparation following the production and feeding process. Using this substance as an indicator to detect the quality of pig bile raw materials can avoid due to composition changes. And the quality risk introduced.

Description

technical field [0001] The invention relates to an isomer of cholanic acid and its detection method and application, belonging to the field of analytical chemistry. Background technique [0002] The spatial configuration of the functional group plays a decisive role in the mechanism of action and clinical efficacy of the compound itself. The most typical case is the famous drug injury event in international history - the teratogenic effect of "reactin". Thalidomide, that is, "thalidomide", its two spatial configurations present completely different pharmacological and toxicological effects, the R type corresponds to a good sedative effect, and the S type has a strong teratogenic effect. Therefore, at the beginning of the 19th century, the research on the spatial configuration was not yet thorough, and the mixed use of the two isomers of thalidomide led to the birth of a large number of "seal children". Another typical drug - glycyrrhizic acid, as the current first-line drug...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/72
CPCG01N30/02G01N30/72
Inventor 焦阳郭东晓尹雪于凤蕊徐兴燕林永强
Owner SHANDONG INST FOR FOOD & DRUG CONTROL
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