Sugar chain structure analysis device and sugar chain structure analysis program

A technology for structure analysis and sugar chain, which is applied in the fields of sugar chain structure analysis devices and programs for sugar chain structure analysis, and can solve problems such as time-consuming, increased retrieval objects, and time-consuming problems.
CN112805560APending Publication Date: 2021-05-14SHIMADZU SEISAKUSHO CO LTD
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
SHIMADZU SEISAKUSHO CO LTD
Publication Date
2021-05-14

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Abstract

In a sugar chain structure analysis device according to an embodiment of this invention, one of a plurality of tabs for setting analysis conditions is dedicated to setting conditions relating to sialic-acid-binding-mode-specific chemical modification, and a user is able to select primary chemical modification reagents. When the reagents are selected, mass changes are automatically set for each binding mode. Further, when a chemical modification other than a predetermined chemical modification is used, the user may numerically input mass change amounts for each binding mode. During analysis, for one chemical modification, the theoretical m / z values of a plurality of sugar chain candidates having m / z values that vary according to the binding mode and the actually measured ion peak m / z values are compared collectively. As a result, when the structure of a sugar chain including a sialic-acid binding mode is analyzed through chemical modification using sialic-acid-binding-mode-specific chemical modification reagents, it is possible to reduce analysis-related user work and improve analysis efficiency.
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Description

technical field

[0001] The present invention relates to a sugar chain structure analysis device for analyzing sugar chain structures by mass spectrometry, and a sugar chain structure analysis program for analyzing sugar chain structures on a computer. Sugar chain structure analysis device for sugar chain structure analysis including sialic acid linkage method, and sugar chain structure analysis program. It should be noted that the "sugar chain" referred to here includes not only sugar chains that exist alone, but also sugar chains in the state of modifying biomolecules such as proteins, peptides, lipids, and nucleic acids, that is, modified sugar chains. Background technique

[0002] The biosynthesis process of biomolecules such as proteins and peptides in organisms is finely regulated. Therefore, it is increasingly believed that sugar chain-modified biomolecules produced through biosynthesis play an important role in life activities. specific reports. From this current s...

Claims

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