Application of mexiletine in preparation of product for treating and/or preventing faciocervical skin wrinkles

A skin wrinkle and mexiletine technology, applied in the field of mexiletine application, can solve the problems of short duration of face and neck wrinkle removal effect, poor facial wrinkle reduction effect, etc., to achieve cheap and easy to obtain, small side effects, broad The effect of applying the foreground

Active Publication Date: 2021-06-18
PLASTIC SURGERY HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The face and neck anti-wrinkle patch simply moisturizes the skin to reduce deep facial wrinkles, and with the loss of skin moisture, the effect of face and neck anti-wrinkle lasts for a short time

Method used

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  • Application of mexiletine in preparation of product for treating and/or preventing faciocervical skin wrinkles
  • Application of mexiletine in preparation of product for treating and/or preventing faciocervical skin wrinkles
  • Application of mexiletine in preparation of product for treating and/or preventing faciocervical skin wrinkles

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0032] This experimental example is used to verify the effect of mexiletine on the relaxation and inhibition of contraction of facial expression muscles. Mexiletine, the chemical name is 1-(2,6-dimethylphenoxy)-2-propanamine hydrochloride, the common name is mexiletine hydrochloride, and its aliases are slow heart rhythm, mikeding, meiluding, Mann Xilu, the molecular formula is C 11 h 17 NO, the molecular weight is 179.26, the CAS number is 31828-71-4, and the chemical structure formula is:

[0033]

[0034] The above-mentioned mexiletine can be purchased commercially, for example, from Beijing Lanbot Technology Co., Ltd., article number: 31828-71-4, analytical standard, HPLC ≥ 95%.

[0035] Specifically, mexiletine injection was used to inject 1 mL each on the upper and lower lids of the left eye of the rabbit. At the same time, 1 mL of normal saline was injected into the upper and lower eyelids of the rabbit's right eye as a control. Stimulate the conjunctiva and eyel...

experiment example 2

[0039] Preparation of mexiletine anti-wrinkle patches, such as figure 1 As shown, the anti-wrinkle patch includes a protective layer 1, a mexiletine hydrogel layer 2 and an adhesive layer 3 arranged sequentially from top to bottom, and the upper surface of the protective layer 1 is connected to the surface of the hydrogel layer 2. The following table is anti-wrinkle fitting, the upper surface of the mexiletine hydrogel layer 2 is anti-wrinkle fitting with the bottom surface of the adhesive layer 3, the protective layer 1, the mexiletine hydrogel layer 2 It is flush with the adhesive layer 3 .

[0040] Using the mexiletine anti-wrinkle patch prepared above, the effectiveness of the mexiletine anti-wrinkle patch on improving facial and neck skin wrinkles was evaluated by actually using the mexiletine anti-wrinkle patch. Forty healthy volunteers aged 30-40 were recruited and randomly divided into a test group and a control group of 20 people each. Volunteers in the test group w...

experiment example 3

[0050]Using the mexiletine anti-wrinkle patch prepared in the above experimental example 2, by comparing the effect of mexiletine anti-wrinkle patch and ordinary hydrogel anti-wrinkle patch on improving facial and neck skin wrinkles, verify the anti-wrinkle effect of mexiletine anti-wrinkle patch Advantage. The difference from the mexiletine anti-wrinkle patch is that the ordinary hydrogel anti-wrinkle patch uses a hydrogel layer instead of the mexiletine hydrogel layer, and the rest are the same. Forty healthy volunteers aged 30-40 were recruited and randomly divided into a test group and a control group of 20 people each. Volunteers in the test group were given mexiletine anti-wrinkle patch for wrinkles around the eyes, once in the morning and once in the evening. Volunteers in the control group were given ordinary hydrogel anti-wrinkle patches for wrinkles around the eyes, once in the morning and once in the evening. The two groups of volunteers insisted on using their re...

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Abstract

The invention discloses an application of mexiletine in preparation of a product for treating and/or preventing faciocervical skin wrinkles, and belongs to the technical field of mexiletine application. Researches show that mexiletine can effectively prevent and reduce faciocervical skin wrinkles, and can be used for preparing the product for treating and/or preventing faciocervical skin wrinkles; and therefore, a new application field of mexiletine is developed, the new product for treating and/or preventing faciocervical wrinkles is developed, and the application has a positive pharmaceutical value and a wide social significance.

Description

technical field [0001] The invention relates to the application of mexiletine in the preparation of products for treating and / or preventing facial and neck skin wrinkles, and belongs to the technical field of mexiletine application. Background technique [0002] The contraction of facial muscles and the aging and loosening of the skin on the face and neck are the main reasons for the formation of wrinkles. At present, the main component of the face and neck anti-wrinkle patch commonly used in clinical practice is hydrogel, which mainly reduces facial and neck wrinkles by replenishing water to the skin and delaying skin aging and relaxation. But it has little effect on the contraction of facial and neck muscles, which is the cause of wrinkles. The anti-wrinkle patch for the face and neck is not effective in reducing deep facial wrinkles simply by moisturizing the skin, and with the loss of skin moisture, the effect of anti-wrinkle on the face and neck lasts for a short time....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/138A61P17/18
CPCA61K31/138A61P17/18
Inventor 孙鹏飞潘博王长琛黄鑫邢梦婷
Owner PLASTIC SURGERY HOSPITAL CHINESE ACAD OF MEDICAL SCI
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