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Dammarane type tetracyclic triterpenoids and extraction method and application thereof

A dammarane-type, tetracyclic triterpene technology, which is applied in the field of Cyclocarya paliurus extract, can solve the problems of activity and mechanism research.

Active Publication Date: 2021-06-18
CENT SOUTH UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology allows us to make extraction methods that are easy enough but still effective at producing specific types of molecules called deoxyvenols or perillanes with certain structures like those found naturally occurring within plants such as Vanilla planifolia (a type of plant used widely throughout Europe). These extracted products can then help researchers study their pharmacology by studying how they work on rheuma symptoms caused by inflammatory processes affecting joints.

Problems solved by technology

This patented technical problem addressed by this patents relates to studying cycloposperoxygenases from plants called Codonopsis lancasteris or Trichoderma spp., specifically understanding how they work with different substances such as sterols, fatty acids, chlorophyllanes, tetrathyrones, etc.

Method used

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  • Dammarane type tetracyclic triterpenoids and extraction method and application thereof
  • Dammarane type tetracyclic triterpenoids and extraction method and application thereof
  • Dammarane type tetracyclic triterpenoids and extraction method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0048] 1.1 Treatment of Cyclocarya paliurus medicinal materials: Dry leaves of Cyclocarya paliurus (10Kg), crush and extract with 70% ethanol under reflux at 120°C (100L; 2×2h), concentrate at 60°C to obtain extract, and the concentration time is 2 days. The extract was further dispersed in water, extracted with dichloromethane, ethyl acetate, and n-butanol in sequence, 10 L each time, extracted 3 times, and the extract was concentrated at 60°C for 24 hours to obtain extracts and concentrates of different polar parts. liquid. The dichloromethane part is mainly dammarane-type tetracyclic triterpenoids (marked as QQL-ST).

[0049] 1.2 Biological activity-oriented screening of active parts of Cyclocarya paliurus: Using adjuvant arthritis rat animal model to track and screen active parts of Cyclocarya paliurus for improving rheumatoid arthritis:

[0050] 1.3 Research on active site components

[0051] 1.3.1 Extraction, separation and purification of triterpenes: Use macroporous ...

Embodiment 2

[0091] Application of QQL-ST and dammarane-type tetracyclic triterpenoids in the preparation of drugs for treating rheumatoid arthritis

[0092] 1. Bioactivity-oriented screening of active sites:

[0093] Anti-RA effect experiment of adjuvant rat model Several SD rats, male, weighing 180-220g, 10 were taken as the normal control group, and the rest were used as the model control group. The rats in the model control group were injected subcutaneously at the right hind foot plantar Freund's complete adjuvant 0.1mL / body, 7 days after modeling, the toe volume meter was used to measure the degree of swelling of the toes, and according to the degree of swelling of the toes, they were randomly divided into model control group, positive control group, and QQL-ST group, each with 6 Animals, the dosage is 150mL / kg. Before daily administration, each compound was formulated with 0.5% CMC-Na to make a suspension of corresponding concentration, and the rats in each group were given the sus...

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Abstract

The invention relates to an extract of cyclocarya paliurus, in particular to a cyclocarya paliurus dichloromethane active part and dammarane type tetracyclic triterpenoids and an extraction method and application thereof. The active part is a dichloromethane extraction concentrated solution of the cyclocarya paliurus, and the main component of the active part is the dammarane type tetracyclic triterpenoids. The structure of the dammarane type tetracyclic triterpenoids is as shown in a formula I or formula II in the specification. The dammarane type tetracyclic triterpenoids 1-26 and the cyclocarya paliurus dichloromethane active part achieve a relatively good effect in the activity test of preparing anti-rheumatoid arthritis drugs, and are expected to become a new-generation anti-rheumatoid arthritis drugs.

Description

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Claims

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Application Information

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Owner CENT SOUTH UNIV
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