Palatable antiparasitic formulations

A palatable agent, palatable technology, applied in the direction of medical preparations containing active ingredients, anti-infective drugs, pill delivery, etc.

Pending Publication Date: 2021-06-25
ZOETIS SERVICE LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to palatability, compositions containing more than one veterinary drug (i.e., an antiparasitic agent) tend to have stability problems, as some agents are acid-labile while others are base-labile

Method used

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  • Palatable antiparasitic formulations
  • Palatable antiparasitic formulations
  • Palatable antiparasitic formulations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Example 1. Common Blends - Compositions

[0085] Excipients / Active Substances Approx w / w% of total tablet Sharona 1.3 moxidectin 0.03 pyrantel pamoate 16.0 stabilizer 2.4 disintegrant 15.2 Glidants and lubricants 1.25 Savory Blend* 42 Colorant 1 filler 19.7 Adhesive 1.1 Antioxidants 0.02 total 100

[0086] *The blend comprises at least one natural animal-based palatable agent; and each of at least one natural palatable agent, sweetener, filler, and binder. Binder and filler amounts listed are those in the palatable blend only.

[0087] biology

[0088] The composition (generic blend) is compressed into at least six (6) different tablet strengths and sizes to accommodate a range of dog weights; such that each dog will receive, on average, about 1.2 mg / kg of salolana; 5 mg / kg pyrantel; and 24 μg / kg moxidectin; a combination product. The palatable hard chewable tablet is administ...

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Abstract

The present invention is directed to a palatable, hard chewable composition comprising a therapeutically effective amount of a veterinary acceptable isoxazoline, a stabilized macrocyclic lactone, an acceptable salt form of pyrantel, at least one natural animal based palatant, and at least one veterinary acceptable excipient; and methods for treating or preventing a parasitic infection or infestation in an animal in need thereof with said composition.

Description

[0001] field of invention [0002] The present invention describes a palatable hard chewable composition comprising at least one veterinarily acceptable isoxazoline, a stable macrolide, an acceptable salt form of pyrantel, at least one A natural animal based palatant and at least one veterinary acceptable excipient. The palatable composition is compressed into hard tablets. The present invention also contemplates a method of use for treating and / or preventing a parasitic infection or infestation in an animal in need thereof by administering said composition to said animal. [0003] Background of the invention [0004] Formulation of a drug (i.e., active agent) into an edible drug (eg, a palatable chewable dosage form) increases subject acceptance of the drug, especially the tendency to resist swallowing hard tablets or capsules and chewing bitter and / or Granules for animals. Flavoring agents (palatants) and polymer coatings are often used to impart a degree of palatability t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/365A61K31/7048A61K31/506A61K31/4155
CPCA61K9/2054A61K9/2068A61K31/365A61K31/7048A61K31/506A61K31/4155A61K9/0056A61K9/2018A61K9/0058A61K31/42A61K31/422A61P33/10A61K2300/00A61P33/00
Inventor S·P·科尔赫S·G·塔库尔
Owner ZOETIS SERVICE LLC
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