Application of SR1078 in preparation of drugs for treating alcoholic liver injury and medicine composition

Abstract

The invention relates to the technical field of new application of drugs, in particular to application of SR1078 in preparation of drugs for treating alcoholic liver injury and a medicine composition. The embodiment of the invention proves that SR1078 improves the liver / body weight ratio of a mouse with the alcoholic liver disease; the SR1078 can improve the serum enzymology index of a mouse, so that the content of alanine transaminase (ALT) and aspartate transaminase (AST) of the mouse with the alcoholic liver disease is obviously reduced; the SR1078 can improve the endoplasmic reticulum stress condition of the liver of a mouse with the alcoholic liver disease, ROR alpha is increased, and key proteins ATF4 and CHOP of endoplasmic reticulum stress are reduced; the SR1078 can improve liver injury and lipid accumulation caused by alcohol. The application provides a new strategy for treatment of the alcoholic liver disease, has important clinical treatment significance, shows that the SR1078 can be used as an active ingredient of the alcoholic liver injury treatment medicine, and provides a scientific basis for development of the alcoholic liver disease treatment medicine in the future.

Description

Technical field [0001] The present invention relates to the field of new drug use techniques, and more particularly to SR1078 in the preparation of a medicament for the treatment of alcoholic liver injury drugs, pharmaceutical compositions. Background technique [0002] China is a country that has caused the most dead, and the burden of disease caused by drinking is also aggravating. In my country, the number of patients with alcoholic liver disease accounts for 4.5% of the total number, reaching 62 million. Alcoholic liver disease (ALD) has three main stages: alcoholic fatty liver disease, alcoholic hepatitis and cirrhosis. Alcoholic fatty liver disease, which is characterized by accumulation of fatty acids in the liver, usually irreymptomatic and reversible after alcohol. Although most severe drinkers show a certain level of fatty liver disease, in some cases, a large number of drinking only needs to happen in less than a week, and only one of the five severe drinkers are alcoh...

AI Technical Summary

Problems solved by technology

It is widely distributed in various tissues in the body, has a variety of important physiological functions, affects the regulation of inflammatory response, the regulation of lipid metabolism, the development of nerve tissue, lymphocytes, etc., and the differentiation of B and T lymphocytes. To verify the treatment of diseases related to the regulation of response and lipid metabolism, RORα agonists will be tried, but there is no report on the research of SR1078 in the treatment of alcoholic liver injury

Images