Application of organic amine additive in synthesis of fluorescent dye intermediate through olefin hydroformylation reaction

Abstract

The invention discloses application of an organic amine additive in synthesis of a fluorescent dye intermediate through olefin hydroformylation reaction, and the application comprises the following steps: S1, the structure of the additive involved in the patent takes a nitrogen atom as a center, and three substituent groups linked with the nitrogen atom are alkyl groups or aromatic groups; and S2, in the hydroformylation reaction process, very few additives are introduced into the reaction system. The activity of a rhodium-aryl phosphine catalyst and the chemical selectivity of a product aldehyde can be obviously improved by using proper types and quantity of additives. The organic amine additive has the characteristics that compared with other types of additives reported in the literature, the organic amine additive can better regulate and control the activity of a rhodium-aryl phosphine catalyst and greatly improve the chemical selectivity of the product aldehyde, the organic amine additive provided by the invention can overcome the defects of other types of additives reported in the literature, and the cost of hydroformylation industrial production of various olefins is reduced.

Description

technical field [0001] The invention relates to the field of application of organic amine additives in the synthesis of fluorescent dye intermediates by olefin hydroformylation, in particular to the application of organic amine additives in the synthesis of fluorescent dye intermediates by olefin hydroformylation. Background technique [0002] In the process of practical application of hydroformylation reaction, it will be accompanied by the problem that the chemical / regioselectivity of product aldehydes is difficult to control. This patent mainly involves a class of organic amine additives containing nitrogen atoms to regulate the rhodium catalyst in various olefins. In the hydroformylation reaction, the hydrogenation reaction of olefins and the isomerization reaction of olefins can be well inhibited, thereby solving the problem of difficult control of the chemoselectivity of the reaction and the regioselectivity of the product, and it is used in the synthesis of fluorescent...

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Problems solved by technology

[0002] In the process of practical application of hydroformylation reaction, it will be accompanied by the problem that the chemical / regioselectivity of product aldehydes is difficult to control. This patent mainly involves a class of organic amine additives containing nitrogen atoms to regulate the rhodium catalyst in various olefins. In the hydroformylation reaction, the hydrogenation reaction of olefins and the isomerization reaction of olefins can be well inhibited, thereby solving the problem of difficult control of the chemoselectivity of the reaction and the regioselectivity of the product, and it is used in the synthesis of fluorescent dye intermediates Provides new ways of thinking

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