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Liquid dispensing system for a microfluidic sample carrier, microfluidic sample carrier sealing system including such liquid dispensing system, and method for dispensing sealing liquid using the same

A dispensing system, sample holder technology, applied in chemical instruments and methods, biochemical equipment and methods, fluid controllers, etc., can solve problems such as hydrostatic influence, material properties or flushing behavior that are not fully considered

Pending Publication Date: 2021-08-13
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the previously proposed solutions did not provide adequate results, since in particular hydrostatic influences, material properties or flushing behavior were not adequately considered

Method used

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  • Liquid dispensing system for a microfluidic sample carrier, microfluidic sample carrier sealing system including such liquid dispensing system, and method for dispensing sealing liquid using the same
  • Liquid dispensing system for a microfluidic sample carrier, microfluidic sample carrier sealing system including such liquid dispensing system, and method for dispensing sealing liquid using the same
  • Liquid dispensing system for a microfluidic sample carrier, microfluidic sample carrier sealing system including such liquid dispensing system, and method for dispensing sealing liquid using the same

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Embodiment Construction

[0111] An embodiment of the dispensing system 1 according to the invention is in figure 1 is shown in a partially cutaway perspective view, wherein the structure of the dispensing system 1 is shown in an exploded manner in order to be able to describe the structural relationship between these components in an improved manner. In addition, in figure 1 In , the microfluidic sample holder 9 is shown next to the distribution system 1, in particular in a position below the distribution system 1, wherein the filling of the microfluidic sample holder 9 by the distribution system 1 can only take place when the microfluidic sample holder 9 is positioned below the distribution system 1. Fluid sample holder9. Here, the combination of distribution system 1 and microfluidic sample holder 9 constitutes a microfluidic sample holder sealing system 10 according to the present invention. In order to better illustrate the main components of the dispensing system 1, figure 1 Certain components...

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Abstract

The present invention is directed to a dispensing system for providing a preset small volume of liquid <= 200 [mu]l into a filling area of a microfluidic sample carrier comprising at least one flow channel, the system including, inter alia, at least one interface unit provided for each flow channel of the microfluidic sample carrier, with each interface unit comprising an injector with an injection channel, wherein the cross section of an outlet part of the injection channel is larger than a cross section of an inlet part of the injection channel and of the middle part of the injection channel. Furthermore, the present invention relates to a respective microfluidic sample carrier sealing system and to a respective method of dispensing sealing liquid into a microfluidic sample carrier.

Description

technical field [0001] The present invention generally relates to the technical field of preparation of sample analysis, such as biological sample analysis, and further relates to the technical field of preparation of high throughput analysis of biological samples. [0002] In particular, the present invention relates to a dispensing system for providing a predetermined volume of liquid into a filling area of ​​a microfluidic sample holder comprising at least one flow channel, said at least one Flow channels provide microwell arrays to act as reaction chambers for chemical or biological reactions. Here, the goal is often to be able to perform multiple different assays on one or more test samples on the same (typically disposable) microfluidic sample holder, eg by thermal cycling. Therefore, in order to be able to further process the test sample, the microwell array pre-filled with the test sample and, for example, a plurality of different reagents must be sealed in order to a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B01L9/00C12M1/00C12M1/36C12Q1/686
CPCB01L3/5027B01L9/527C12Q1/686B01L2200/027B01L2200/10B01L3/502715B01L2300/0877B01L2300/0816B01L2200/0689B01L3/0203B01L2400/0487G01N35/1072G01N35/1097B01L3/502738
Inventor J·迪图斯T·瓦尔兹A·赫特J·卡舍夫V·巴伦辛
Owner F HOFFMANN LA ROCHE & CO AG
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