Enteral nutrition powder suitable for 1-10-year-old children with dyslipidemia and preparation method of enteral nutrition powder

A technology for abnormal lipid metabolism and enteral nutrition, applied in the field of enteral nutrition powder and its preparation, can solve the problems of excess trace elements, mitochondrial swelling, increased membrane permeability and fragility, etc.

Inactive Publication Date: 2021-08-27
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In November 2012, the European Commission (European Commission, EC) approved Glybera, the first gene therapy drug in the western world, to repair gene defects, but its price is very expensive, beyond the economic burden of ordinary families
[0006] For the lipid metabolism disorder in children, it is necessary to limit the content of long-chain fatty acids in the diet for a long-term or short-term, so that the normal physiological needs of the body for nutrients cannot be met, and the following problems will occur: First, the children mainly through restriction Food types and cooking methods limit fat intake, which is closely related to family members' knowledge of nutrition. Parents of children often cannot accurately distinguish foods with high long-chain triglyceride content, which leads to aggravation of the child's condition; second, restrict long-chain triglyceride content. The intake of fatty acids can easily lead to the lack of essential fatty acids in children. Essential fatty acids are needed by the human body but cannot be synthesized by themselves. Simply relying on exogenous input, the lack of essential fatty acids can lead to mitochondrial swelling, changes in the structure and function of cell membranes, and membrane damage. Permeability and fragility increase, and symptoms of essential fatty acid deficiency such as rough skin, blurred vision, and peripheral neuritis appear; third, insufficient fat intake will also be accompanied by a lack of fat-soluble vitamins, resulting in skin keratosis, rickets, etc. Fat-soluble vitamin deficiency; due to the small stomach capacity of children, and the small volume and high energy density of fatty acids, long-term restriction of fatty acid intake in children can easily lead to insufficient energy intake in children
[0007] At present, the existing enteral nutrition powders with low long-chain triglyceride content in the market mainly include low-fat complete nutritional powders of brands such as Lishikang, Licun, Vicanon, Yabao Weiyuan, etc. The fat content is generally 1.7~ 2.5g / 100g, mainly derived from vegetable oil, can only reduce the intake of long-chain fatty acids by reducing the fat content, low energy density, suitable for people over 10 years old; in addition, the content of vitamins and minerals are based on the nutritional needs of adults Addition, long-term consumption is prone to excess or deficiency of trace elements, and is not suitable for clinical application in children, so there is still a lack of enteral nutrition preparations suitable for children with abnormal lipid metabolism from 1 to 10 years old

Method used

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  • Enteral nutrition powder suitable for 1-10-year-old children with dyslipidemia and preparation method of enteral nutrition powder
  • Enteral nutrition powder suitable for 1-10-year-old children with dyslipidemia and preparation method of enteral nutrition powder
  • Enteral nutrition powder suitable for 1-10-year-old children with dyslipidemia and preparation method of enteral nutrition powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: 455.5kcal of energy is provided per 100g, and the energy ratio is 22.0% for protein energy supply, 47.4% for carbohydrates, 30.6% for fat, and fat is made up of omega-3, omega-6 and medium-chain triglyceride (MCT), The percentage by weight of ω-3: ω-6: MCT is 2.5%-3.2%: 10%-13%: 84%-87%. The protein content in this example is relatively high, which is conducive to correcting the protein level of children with acute lymphoblastic leukemia, maintaining the nitrogen balance and energy supply during chemotherapy in children with acute lymphoblastic leukemia, and helping to alleviate adverse reactions during chemotherapy. It is suitable for acute lymphoblastic leukemia children aged 1 to 10 years old Peri-pegaspargase chemotherapy in children with lymphocytic leukemia.

[0036]

[0037]

[0038] The preparation method of the enteral nutrition powder suitable for children with abnormal lipid metabolism aged 1 to 10 comprises the following steps:

[0039] ...

Embodiment 2

[0045] Embodiment 2: This embodiment provides energy 455.5kcal per 100g, protein energy supply ratio is 12.3%, carbohydrate 57.1%, fat 30.6%, fat is made up of omega-3, omega-6 and medium chain triglyceride (MCT) , ω-3: ω-6: The weight percentage of MCT is 2.5%-3.2%: 10%-13%: 84%-87%. In this example, the ratio of each macronutrient is balanced and reasonable, which meets the energy and nutrient requirements of the 1-10-year-old population. It is suitable for long-term use in children with abnormal lipid metabolism.

[0046]

[0047]

[0048] The preparation method of the enteral nutrition powder suitable for children with abnormal lipid metabolism aged 1 to 10 comprises the following steps:

[0049] (1) According to the proportion, weigh each component, put the mixture formed by each component into the mixer, add 55°C pure water, pass in the inert gas nitrogen, stir at 600rpm for 12min until fully dissolved and mixed Obtain the first mixed slurry; The weight ratio of ...

Embodiment 3

[0059] Embodiment 3: this embodiment nutrition powder provides 455.5kcal energy per 100g, wherein the energy supply ratio of protein is 8.8%, carbohydrate 60.1%, fat 30.6%, fat is composed of omega-3, omega-6 and medium chain triglyceride ( MCT), wherein the weight percentage of ω-3: ω-6: MCT is 2.5%~3.2%: 10%~13%: 84%~87%. The content of carbohydrates in this example is rich, which can effectively avoid the rapid metabolism and oxidation of MCT to form a large amount of ketone bodies and cause ketosis. The protein content is low, which can meet the basic protein needs of people aged 1 to 10 and maintain nitrogen balance. At the same time, the low protein content is beneficial to reduce the stimulation of the pancreas and the secretion of pancreatic juice. It is suitable for acute pancreatitis patients aged 1 to 10 It will be activated after the child's condition is stable.

[0060]

[0061] The preparation method of the enteral nutrition powder suitable for children with ...

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Abstract

The invention relates to a special enteral nutrition powder suitable for 1-10 year old children with dyslipidemia and a preparation method of the enteral nutrition powder, and the special enteral nutrition powder comprises the following components in parts by weight: 10-25 parts of protein, 15.5 parts of fat, 54-69 parts of carbohydrate, 0.05-0.15 part of vitamin, 0.5-2.5 parts of mineral substance, 0.01-0.03 part of L-carnitine tartrate, 0.01-0.03 part of taurine and 2.0-4.0 parts of water. The invention has the advantages that: every 100g of the product can supply 455.5 kcal of energy, contains six nutrients required by a human body, does not contain dietary fiber or lactose, and is beneficial to improving the intestinal tolerance.

Description

technical field [0001] The invention relates to an enteral nutrition powder, in particular to an enteral nutrition powder for children with abnormal lipid metabolism aged 1 to 10 and a preparation method thereof. Background technique [0002] Infancy and childhood are critical periods of growth and development. The growth of height and weight is accompanied by the gradual differentiation of organs and the gradual maturity of functions. Reasonable dietary preparation is the basis for maintaining a good nutritional status and healthy development of the body. Some diseases can lead to insufficient nutrient intake and / or increased energy consumption, which may cause malnutrition in children, such as familial hyperchylomicronemia in infants and children, children with acute lymphoblastic leukemia treated with pegaspargase The lipid metabolism disorder caused by a sharp increase in blood lipid levels, postoperative children with congenital biliary atresia, children with cholecysti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00
CPCA23L33/40A23V2002/00A23V2200/30A23V2250/186A23V2250/1944A23V2250/54252A23V2250/5114A23V2250/0644A23V2250/70A23V2250/156
Inventor 韩磊冯硕盛琦陈春燕马莉李怡婧王丹丹赵鹏图
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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