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Application of mechanism of BMP2 silencing in elimination of renal calcium oxalate calculus injuries

A kidney calcium oxalate, 1.BMP2 technology, applied in the field of biomedicine, can solve the problems of unclear IH function and mechanism

Pending Publication Date: 2021-09-14
WEST CHINA HOSPITAL SICHUAN UNIV
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Problems solved by technology

Although IH is a high-risk factor for kidney stones, the role and mechanism of IH in kidney stone formation are currently unclear

Method used

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  • Application of mechanism of BMP2 silencing in elimination of renal calcium oxalate calculus injuries
  • Application of mechanism of BMP2 silencing in elimination of renal calcium oxalate calculus injuries
  • Application of mechanism of BMP2 silencing in elimination of renal calcium oxalate calculus injuries

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Embodiment

[0014] In this example, the following materials were prepared: 30 SD male rats (SPF grade, 6 weeks), purchased from Chengdu Dashuo Animal Experiment Co., Ltd., Sichuan, and raised in the West China Animal Experiment Center of Sichuan University; the feeding environment was 25 ± 1 ° C, The relative humidity was 50%-60%, and the light / dark cycle was 12 hours. SD rats could eat and drink freely. All experiments were approved by the ethics committee of West China Hospital of Sichuan University.

[0015] Establish a hyperoxaluria rat model: SD rats are randomly divided into 5 groups (n=6), i.e. a control group, and each rat drinks 70ml of water ad libitum every day; 0.1% ethylene glycol group; 0.5% ethylene glycol group; 1% ethylene glycol group; 1.5% ethylene glycol group, ethylene glycol induction group rats drink 1% (v / v) ethylene glycol solution 70ml freely every day, the concentration is respectively 0.1%, 0.5%, 1%, 1.5% %; normal feeding for 4 weeks, at the end, rats were ane...

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Abstract

The invention relates to the field of biological medicines, and discloses application of a mechanism of BMP2 silencing in elimination of renal calcium oxalate calculus injuries, and the mechanism is as follows: CaOx crystal deposition and renal cell injuries are reduced by inhibiting oxidative stress reaction through BMP2 silencing. The invention proves that the BMP2 silencing can alleviate sodium oxalate-induced cell oxidative stress and crystallization, and can inhibit phosphorylation of Smad1 and expression of NOX2 and NOX4, proves that the BMP2 silencing can reduce CaOx crystal deposition and renal cell injuries by inhibiting the oxidative stress reaction, and shows that the BMP2 silencing can eliminate the renal tubular epithelial cell oxidative stress injuries. A new direction is indicated for the pathogenesis research of the calcium oxalate calculus .

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of BMP2 silencing to improve the mechanism of renal calcium oxalate stone damage. Background technique [0002] Kidney stones are one of the common diseases in urology and seriously threaten human health. Kidney stones are caused by mineral deposition in the renal calices and renal pelvis. Hyperuricemia is a common metabolic abnormality in clinical practice. It is the main risk factor for calcium oxalate stones and the main component of most stones. Hyperoxaluria is an important cause of kidney stones. Reports show that the incidence of adult idiopathic hypercalciuria (Idiopathic hypercalciuria, IH) is 5% to 8%, and the incidence of urinary stones in IH patients is 5 times that of normal people. Although IH is a high-risk factor for kidney stones, the role and mechanism of IH in kidney stone formation are currently unclear. Renal epithelial cell damage plays a decisiv...

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Application Information

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IPC IPC(8): A61K38/18A61P13/04A61P13/12
CPCA61K38/1875A61P13/04A61P13/12
Inventor 魏志涛
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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