Veterinary traditional Chinese medicine preparation and preparation method thereof

A traditional Chinese medicine preparation and technology of traditional Chinese medicine, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc.

Pending Publication Date: 2021-09-17
张莜玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method effectively solves the problems of fat-soluble traditional Chinese medicine composition crystallization and easy oxidation during long-term storage, thereby improving the efficacy and stability of traditional Chinese medicine preparations

Method used

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  • Veterinary traditional Chinese medicine preparation and preparation method thereof
  • Veterinary traditional Chinese medicine preparation and preparation method thereof
  • Veterinary traditional Chinese medicine preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A preparation method for veterinary Chinese medicine nasal drops, characterized in that, proceed as follows:

[0052] Step (1): preparing traditional Chinese medicine clear ointment

[0053] (1) extraction

[0054] A. According to the weight components, put 20 parts of ephedra, 10 parts of licorice, 50 parts of ginseng, 30 parts of berberine, and 15 to 22 parts of angelica at 60°C for two extractions. The first time is based on the total amount of medicinal materials and ethanol The mass ratio of the solution is 1:15, add an ethanol solution with a volume fraction of 70%, extract for 2 hours, and collect the extract. The second time is to add a volume fraction of 50-70% according to the mass ratio of the total amount of medicinal materials to the ethanol solution at 1:12. The ethanol solution was extracted for 1.5 hours, the extracts were collected, the two collected extracts were combined, the ethanol was recovered at -0.05MPa and the temperature was 60°C, and concent...

Embodiment 2

[0073] A preparation method for veterinary Chinese medicine nasal drops, characterized in that, proceed as follows:

[0074] Step (1): preparing traditional Chinese medicine clear ointment

[0075] (1) extraction

[0076] A. According to the weight components, 30 parts of ephedra, 20 parts of licorice, 70 parts of ginseng, 50 parts of berberine, and 22 parts of angelica are placed at 70 ° C for two extractions. The first time is based on the total amount of medicinal materials and the quality of the ethanol solution The ratio is 1:18, adding a volume fraction of 90% ethanol solution, extracting for 2 hours, collecting the extract, and the second time adding a volume fraction of 70% ethanol solution according to the mass ratio of the total amount of medicinal materials to the ethanol solution is 1:15, Extract for 1.5 hours, collect the extracts, combine the two collected extracts, recover ethanol at -0.08MPa and 70°C, and concentrate to a clear paste with a relative density of...

Embodiment 3

[0093] A preparation method for veterinary Chinese medicine nasal drops, characterized in that, proceed as follows:

[0094] Step (1): preparing traditional Chinese medicine clear ointment

[0095] (1) extraction

[0096] A. According to the weight components, 15 parts of ephedra, 15 parts of licorice, 60 parts of ginseng, 40 parts of berberine, and 20 parts of angelica are placed at 65 ° C for two extractions. The first time is based on the total amount of medicinal materials and the quality of the ethanol solution The ratio is 1:16, adding an ethanol solution with a volume fraction of 80%, extracting for 2 hours, and collecting the extract. The second time is to add an ethanol solution with a volume fraction of 60% according to the mass ratio of the total amount of medicinal materials to the ethanol solution at a mass ratio of 1:13. Extract for 1.5 hours, collect the extracts, combine the two collected extracts, recover ethanol at -0.06MPa and 65°C, and concentrate to a cle...

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Abstract

The invention relates to a veterinary traditional Chinese medicine preparation which is a nasal drop. The veterinary traditional Chinese medicine preparation comprises a traditional Chinese medicine clear paste, a solvent and other auxiliary materials, wherein the traditional Chinese medicine clear paste is prepared from the following traditional Chinese medicine raw materials in parts by weight: 20-30 parts of common andrographis herb, 30-60 parts of ligusticum wallichii, 50-70 parts of ginseng, 30-50 parts of coptis chinensis, 20-30 parts of ephedra, 10-20 parts of liquorice and 15-22 parts of radix angelicae; the solvent is a mixed solvent formed by glycerinum and ethylenediamine tetraacetic acid; the other auxiliary materials comprise 0.5-0.8% by mass volume fraction of methylparaben and 1-3% by mass volume fraction of citric acid; the mass ratio of the traditional Chinese medicine clear paste to the methylparaben to the mixed solvent is 1: (10-20): (50-80); and the pH is adjusted to 5.0-5.5 by citric acid. The prepared traditional Chinese medicine nasal drop for treating cold is stable in property; the color of the solution does not change after being placed for a long time of 24 months; the content of effective components such as andrographolide, berberine hydrochloride and ephedrine in the nasal drop is kept stable and unchanged; the fat-soluble traditional Chinese medicine components do not have any crystallization phenomenon; the nasal drop is fast in drug effect when used for treating cold of canine animals; and the effective rate reaches 100%.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a veterinary traditional Chinese medicine preparation and a preparation method thereof. Background technique [0002] Sleeping in the open during cold nights, lying in the cold for a long time, being exposed to rain after sweating profusely, being stimulated by cold water when wading across the river, being kept in a cold and humid environment for a long time, or not drying in time after bathing, or entering and exiting an environment with a large temperature difference, these It is very easy for animals to catch a cold. Colds will cause animals such as dogs to sneeze frequently, runny nose, mouth breathing with stuffy nose, lack of energy, and not eating. If it spreads to the respiratory tract and causes respiratory infections, the dog's nose will Turn into yellow, green nasal mucus or pus-white viscous nasal mucus, and symptoms such as persistent cough, shor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K9/08A61K47/10A61K47/12A61K47/14A61K47/18A61P11/00
CPCA61K36/19A61K36/236A61K36/258A61K36/718A61K36/17A61K36/484A61K36/232A61K9/08A61K9/0043A61K47/10A61K47/183A61K47/14A61K47/12A61P11/00A61K2236/333A61K2236/37A61K2300/00
Inventor 张莜玲
Owner 张莜玲
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