A kind of pharmaceutical composition for treating duodenal ulcer

Abstract

The invention discloses a pharmaceutical composition for treating duodenal ulcer, comprising 0.1-0.3 parts of the compound of formula I, 0.01-0.05 parts of honokiol, 0.01-0.02 parts of gallic acid and 0.05-0.1 parts of methyl rosmarinate parts, prepared as a pharmaceutical composition for external use. Experiments show that the interaction between the components of the pharmaceutical composition containing the compound of formula I, honokiol, gallic acid, methyl rosmarinate and dihydroflavonoid glycosides as the main components of the present invention can repair the damaged intestinal wall in rats. tissue, inhibit gastric acid secretion, and have a therapeutic effect on duodenal ulcers.

Description

technical field [0001] The invention belongs to the field of pharmaceutical composition preparations, in particular to a pharmaceutical composition for treating duodenal ulcer. Background technique [0002] Duodenal ulcer is one of the most common clinical digestive system diseases, and is a common type of peptic ulcer. The pathogenic causes may be related to Helicobacter pylori infection, excessive gastric acid secretion, or the use of non-steroidal anti-inflammatory drugs, genetic factors, stress, irregular life and diet, work and external pressure. , smoking, drinking, and mental and psychological factors are closely related. It mostly occurs in winter and spring when climate changes are relatively large, and the incidence rate of males is significantly higher than that of females. [0003] Duodenal ulcers mostly occur in the duodenal bulb, and rhythmic and periodic pain in the upper abdomen or under the xiphoid process is the main symptom. It usually occurs two hours a...

AI Technical Summary

Problems solved by technology

Due to the reasonable application of a large number of new acid-suppressing drugs, antacid drugs, mucosal protective agents and antibiotics, most patients with duodenal ulcer can be healed in a short period of time, but the disease cannot be cured fundamentally. The survey shows that the recurrence rate is high, and its high recurrence rate and a small number of refractory duodenal ulcers are still a major clinical problem to be solved urgently

Based on the above-mentioned observations on the clinical application of commonly used western medicines, more and more scholars believe that for the treatment of duodenal ulcer, the current types of medicines are limited, and although the effects are fast, the high recurrence rate makes the patients feel bad about the medicine. At the same time, the above-mentioned drugs may have certain adverse stimuli. Therefore, it is necessary to further study drugs that can clearly treat duodenal ulcer with small adverse reactions and low recurrence rates.

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