Tacrolimus sunscreen ointment suitable for damaged skin and preparation method thereof

A technology of tacrolimus and ointment, which is applied in the field of sunscreen products, can solve problems such as skin withdrawal symptoms that are difficult to correct, telangiectasia, and hormone dependence, and achieve the effects of promoting skin cell proliferation, repairing damaged skin, and preventing oxidative damage Effect

Pending Publication Date: 2021-10-01
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term external application of hormone ointment can lead to adverse reactions such as skin atrophy, telangiectasia, hair thickening, pigmentation, and even hormone dependence. Once the drug is stopped, the skin will produce withdrawal symptoms that are difficult to correct

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A Kapos sunscreen ointment for damaged skin, prepared from the weight of the weight of the following weight: Tamillo 0.1%, mineral oil 4%, 9% carbonate acrylate, nano TiO 2 2.1% of the particles, 1.1% nano-zno particles, 2% of methoxycinic acid ethylhexylhexide, 0.8% wrap treatment agent, 2.6% dispersant, 2% carbonate, 0.8% polystioxyhydric acid 0.8%, moisturizing 4.5%, emulsifier 1.8% and 1.8% film forming agent, and the remaining amount is deionized water.

[0029] The package treatment agent is a mixture of dimethylsiloxane and silica in accordance with mass ratio of 3: 1.

[0030] The dispersing agent is ethylhexyl palmitate.

[0031] The moisturizer is a mixture of glycerol and polydimethylsiloxane, wherein the mass ratio of glycerol and polydimethylsiloxane is 5: 1.

[0032] The emulsifier is a PEG-10 polydimethylsiloxane.

[0033] The film forming agent is a polypropylene silicone iliacin.

Embodiment 2

[0035] A Kapos sunscreen ointment for damaged skin, prepared from the weight of the following weight: Thame Moss 0.1%, mineral oil 8%, 3% carbonate acrylate, nano TiO 2 Particles 4.3%, nano ZnO particles, 5% of methoxy succinate, 3.5%, dispersant 5.5%, 5% carbonate, 4.7% polystioxyhydric acid, moisturic acid The agent is 9.2%, the emulsifier 3.8% and the film forming agent are 3.8%, and the remaining amount is deionized water.

[0036] The package treatment agent is a mixture of dimethylsiloxane and silica in accordance with the mass ratio of 1: 1.

[0037] The dispersing agent is ethylhexyl palmitate.

[0038] The emollient is a mixture of glycerol and polydimethylsiloxane, wherein the mass ratio of glycerol and polydimethylsiloxane is 1: 1.

[0039] The emulsifier is a PEG-10 polydimethylsiloxane.

[0040] The film forming agent is a polypropylene silicone iliacin.

Embodiment 3

[0042]A Khames sunscreen for damaged skin, which is suitable for damaged skin, is prepared from the weight of the following weight of the following weight: Tharmus 0.1%, mineral 6% oil, 11% acrolene acrolene, nano TiO 2 The particles were 3.1%, 1.7% of the nano-zno particles, 3.5% of methoxycinicate, 2.2% wrap treatment agent, 3.8% dispersant, 3.6% dithonated carbonate, 2.8% polyroxy stearic acid, moisturizing 6.7%, emulsifier 2.5% and film forming agent 3.1%, the remaining amount of deionized water.

[0043] The package treatment agent is a mixture of dimethylsiloxane and silica in accordance with mass ratio 2: 1.

[0044] The dispersing agent is ethylhexyl palmitate.

[0045] The moisturizer is a mixture of glycerol and polydimethylsiloxane, wherein the mass ratio of glycerol and polydimethylsiloxane is 3: 1.

[0046] The emulsifier is a PEG-10 polydimethylsiloxane.

[0047] The film forming agent is a polypropylene silicone iliacin.

[0048] Examples 1-3 The preparation method ...

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PUM

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Abstract

The invention discloses tacrolimus sunscreen ointment suitable for damaged skin. The tacrolimus sunscreen ointment is prepared from the following raw materials: water, tacrolimus, mineral oil, propylene carbonate, nano TiO2 particles, nano ZnO particles, ethylhexyl methoxycinnamate, a wrapping treatment agent, a dispersing agent, dicapryl carbonate, polyhydroxystearic acid, an emollient, an emulsifying agent and a film-forming agent. The tacrolimus sunscreen cream can inhibit inflammation and improve skin lesion conditions of SLE patients, and also can weaken ultraviolet absorption so as to avoid disease recurrence. Immune abnormality of SLE patients is mostly high-sensitivity skin, the product is easy and convenient to use and has double effects, and the possibility that rash is induced by improper use of some chemical reagents by the SLE patients is also reduced.

Description

Technical field [0001] The present invention relates to the technical field of sunscreen, which is specific to Kamo sunscreen ointment for damaged skin and its preparation method thereof. Background technique [0002] Systemic Lupus Erythematosus, SLE is a self-immune disease that is involved in multi-organ and system, with rash as a main feature. SLE 's pathogenesis and the factors that cause SLE activities have not been clear. At present, the view is that SLE is in response to a certain genetic susceptible background and a variety of incentives, increasing the disease, including environmental factors, gender, genetic and immunological abnormalities. Studies have shown that ultraviolet rays are one of the most important environmental factors that have increased the disease or excessive patients in patients with lupus, and patients who have inspired or aggravated the condition in patients with sunshine during SLE patients as high as 60%. Therefore, while SLE patients are needed w...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K9/06A61K31/436A61K47/34A61K47/14A61K47/10A61P17/00A61P29/00A61P17/16A61P17/18A61P31/04A61P31/10
CPCA61K9/06A61K9/0014A61K31/436A61K47/34A61K47/14A61K47/10A61P17/00A61P29/00A61P17/16A61P17/18A61P31/04A61P31/10
Inventor郑朝晖王倩倩高聪聪史晓飞
OwnerTHE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV