Method for relieving non-alcoholic fatty liver disease by activating AMPK with limonin

A limonin and non-alcoholic technology, applied in the direction of organic active ingredients, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of limonin's influence and its mechanism are unknown, and achieve the goal of improving liver weight increase Effect

Pending Publication Date: 2021-10-01
衢州市人民医院
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of limonin on lipid metabolism in the liver and its mechanism are still unk

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for relieving non-alcoholic fatty liver disease by activating AMPK with limonin
  • Method for relieving non-alcoholic fatty liver disease by activating AMPK with limonin
  • Method for relieving non-alcoholic fatty liver disease by activating AMPK with limonin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0069] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0070] The invention provides a method for activating AMPK by limonin to relieve non-alcoholic fatty liver, comprising the following steps:

[0071] Step 1: selection of experimental animals, C57BL / 6 mice were selected as animals;

[0072] Step 2: Grouping the experimental animals, the experimental animals were randomly divided into 4 groups: a normal diet control group, a normal diet limonin treatment group, a high-fat diet modeling group, and a high-fat diet...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for relieving non-alcoholic fatty liver disease by activating AMPK with limonin, wherein the method comprises the following steps: selecting a test animal: selecting C57BL/6 mice as animals; grouping test animals, wherein the test animals are divided into a normal diet control group, a normal diet limonin treatment group, a high-fat diet modeling group and a high-fat diet limonin treatment group; feeding the test animals; and testing and detecting. The test mode of feeding the C57BL/6 mice with limonin shows that no matter the C57BL/6 mice are fed with normal calorie feed or high-fat diet, the food intake of the control group and the food intake of the limonin treatment group have no difference. It is observed that when limonin is used for treating high-fat-diet mice, obvious weight loss can be caused, but when limonin is added or not added into the feed for mice eating common feed, the weight of the mice has no obvious difference, and thus it is indicated that the liver weight increase induced by high-fat-diet feeding can be improved through limonin treatment.

Description

technical field [0001] The invention relates to the field of non-alcoholic fatty liver, in particular to a method for activating AMPK by limonin to relieve non-alcoholic fatty liver. Background technique [0002] Nonalcoholic fatty liver disease, also known as metabolic-related fatty liver disease, is a disease characterized by the pathological accumulation of triglycerides and other lipids in liver cells, which can develop into nonalcoholic steatohepatitis and liver fibrosis, which eventually leads to cirrhosis and hepatocellular carcinoma. Although a variety of small-molecule chemical drugs targeting NAFLD are undergoing clinical trials, the current clinical treatment options for NAFLD are very limited. [0003] AMPK is a key metabolic regulator for sensing energy status in cells and controlling energy consumption and storage. Studies have shown that its activation has a therapeutic effect on non-alcoholic fatty liver disease. AMPK is activated by combining with AMP and A...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/585A61P1/16
CPCA61K31/585A61P1/16
Inventor 张峰王思为陈杭飞蓝天郑芳徐礼锋
Owner 衢州市人民医院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap