Preparation method of poly-L-lactic acid microspheres

A technology of L-polylactic acid and polylactic acid solution is applied in the field of medical cosmetic materials, which can solve the problems of high cost, environment and harm, and achieve the effects of improving safety, short reconstitution time and uniform appearance.

Pending Publication Date: 2021-10-01
上海曜爱生物科技有限公司
View PDF9 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The supercritical fluid dispersion method is used to prepare porous L-lactic acid microspheres with controllable particle size, which solves the high cost and environmental hazards of the traditional solvent volatilization method; physiological saline and lidocaine are used as the dilution components of the microspheres, combined with ultrasonic methods, Achieve instant high dispersibility of microspheres

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of poly-L-lactic acid microspheres
  • Preparation method of poly-L-lactic acid microspheres
  • Preparation method of poly-L-lactic acid microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Dissolve L-polylactic acid in dichloromethane to prepare a polylactic acid solution with a concentration of 0.5 g / L, and place it in a solution holding tank. Adjust the condenser and preheater to the specified temperature of 30°C. Liquid CO 2 Pressed into the high-pressure granulation kettle by the high-pressure pump, after reaching the predetermined pressure of 14MPa, adjust the valve to keep the granulation kettle and the separation kettle in a dynamic balance at a specific temperature and pressure; into the autoclave, the solution and supercritical CO 2 High-speed mixing so that the solution is crushed into very fine droplets, droplets and CO 2 The rapid transfer between them makes the solute in the system supersaturated, and the polylactic acid microspheres are precipitated and precipitated; after the reaction is completed, the pressure in the autoclave is reduced to normal pressure, and the product is centrifugally washed with ultrapure water at a speed...

Embodiment 2

[0028] Example 2 Dissolve L-polylactic acid in methylene chloride to form a polylactic acid solution with a concentration of 0.5 g / L, and place it in a solution holding tank. Adjust the condenser and preheater to the specified temperature of 75°C. Liquid CO 2 Pressed into the high-pressure granulation kettle by the high-pressure pump, after reaching the predetermined pressure of 14MPa, adjust the valve to keep the granulation kettle and the separation kettle in a dynamic balance at a specific temperature and pressure; into the autoclave, the solution and supercritical CO 2 High-speed mixing so that the solution is crushed into very fine droplets, droplets and CO 2 The rapid transfer between them makes the solute in the system supersaturated, and the polylactic acid microspheres are precipitated and precipitated; after the reaction is completed, the pressure in the autoclave is reduced to normal pressure, and the product is centrifugally washed with ultrapure water at a speed...

Embodiment 3

[0029] Example 3 Dissolve L-polylactic acid in methylene chloride to form a polylactic acid solution with a concentration of 50 g / L, and place it in a solution holding tank. Adjust the condenser and preheater to the specified temperature of 30°C. Liquid CO 2 Pressed into the high-pressure granulation kettle by the high-pressure pump, after reaching the predetermined pressure of 14MPa, adjust the valve to keep the granulation kettle and the separation kettle in a dynamic balance at a specific temperature and pressure; into the autoclave, the solution and supercritical CO 2 High-speed mixing so that the solution is crushed into very fine droplets, droplets and CO 2The rapid transfer between them makes the solute in the system supersaturated, and the polylactic acid microspheres are precipitated and precipitated; after the reaction is completed, the pressure in the autoclave is reduced to normal pressure, and the product is centrifugally washed with ultrapure water at a speed o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of novel poly-L-lactic acid microspheres. The porous poly-L-lactic acid microspheres with controllable particle size are prepared by adopting a supercritical fluid dispersion method, so that the problems of high cost and environmental harm of a traditional solvent evaporation method are solved; normal saline and dilution components of lidocaine microspheres are selected, and an ultrasonic mode is combined, so that the instant high dispersibility of the microspheres is realized.

Description

technical field [0001] The invention belongs to the field of medical cosmetic materials, in particular to a preparation method of ultra-high molecular weight L-polylactic acid. Background technique [0002] Porous microspheres have a large specific surface area and high porosity, and have received extensive attention from researchers in recent years. The use of biodegradable materials to prepare porous microspheres will have far-reaching application prospects, such as skin repair filling materials, drug release, and tissue engineering fields. Polylactic acid (PLA) is polymerized from lactic acid and has good biocompatibility and biodegradability. The initial raw material for the preparation of polylactic acid is plant starch, which is not only natural and non-toxic in material selection, but also its degradation products are water and carbon dioxide, which can participate in the metabolism of the human body. Poly-L-lactic acid (PLLA) microspheres were first used in Europe,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/18A61L27/50A61L27/58
CPCA61L27/18A61L27/50A61L27/58A61L2400/06
Inventor孙乐青周慧丽张婷婷赵瑾柳仁民
Owner上海曜爱生物科技有限公司