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A medicinal and edible homologous composition for alcohol use disorder and its application

A medicine and food homology, composition technology, applied in the direction of drug combination, application, food science, etc., can solve the problems of liver necrosis, cardiovascular system and nervous system toxicity, etc., to improve depression, liver function and liver lipid metabolism. Improve, suppress the effect of decreasing

Active Publication Date: 2022-05-10
DALIAN UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if taken for a long time, the accumulated acetaldehyde will have a toxic effect on the digestive system, cardiovascular system and nervous system, and even cause liver necrosis in severe cases.

Method used

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  • A medicinal and edible homologous composition for alcohol use disorder and its application
  • A medicinal and edible homologous composition for alcohol use disorder and its application
  • A medicinal and edible homologous composition for alcohol use disorder and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 composition

[0030] 1.1 Preparation of dendrobium extract

[0031] Take 100g of fresh Dendrobium with a water content of 85%, wash it, cut it into 1cm segments, add 200ml of purified water, crush it in a juice extractor for 10 minutes, filter, and collect the filtrate. Add 100ml of pure water to the filtered filter residue, rinse the residual filter residue several times in small amounts, and ultrasonically filter for 20 minutes at 60°C, combine the filtrate twice, centrifuge at 3000r / min for 15 minutes, and carefully draw supernatant. Concentrate in a rotary evaporator (80°C), and finally make a 0.5g / ml dendrobium extract, store at a low temperature of 4°C, and use it for later use.

[0032] 1.2 Preparation of Polygonatum Extract

[0033] Take 60g of dried Rhizoma Polygonatum, wash it with clean water, add 180ml of pure water to soak for 3 hours, then transfer it to a wall breaking machine and crush it for 10 minutes. Transfer the c...

Embodiment 2

[0036] Embodiment 2 Chronic Alcohol Addiction Model Establishment

[0037] In order to better simulate human drinking habits, a mouse alcohol addiction model was established by using two bottles of free choice drinking for 6 weeks. Throughout the experiment, the control group was provided with two bottles of drinking water at the same time, and the model group was provided with water and alcohol solutions at the same time, and the mice were encouraged to drink more alcohol solutions by setting a gradient alcohol concentration (alcohol concentration 3%-10%) . In the experiment, the drinking volume and water volume were measured every day, and the alcohol preference rate of mice was calculated. By measuring the alcohol preference rate of the mice in the first six weeks and the last week, it was found that the alcohol consumption of the mice was basically stable, and showed a steady upward trend with the increase of drinking time, indicating that the alcohol addiction model was ...

Embodiment 3

[0038] Example 3 Protective effect on the liver of alcohol-addicted mice

[0039]Male healthy ICR mice were randomly divided into control group (control), alcohol addiction group (EtOH), kudzu root group (EtOH+PE), compound composition group (EtOH+PDP), 12 in every group, according to the method of embodiment 2 Two-bottle drinking method, different groups were given normal saline, alcohol, alcohol+pueraria root, alcohol+composition. Pueraria lobata group was administered intragastrically with physiological saline dissolved with puerarin powder, which was equivalent to 5 g / kg of pueraria powder. The final concentration of the extract in the composition group is 0.5g / ml, and the dosage of the mice is 10ml / kg, which is equivalent to 5g / kg of the original medicinal material.

[0040] After the experiment, the mice were sacrificed, and the livers of the mice were taken out, and the livers were stained with hematoxylin-eosin (HE) to examine histological changes. The hepatocytes in...

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Abstract

The invention discloses a medicine and food homologous composition for alcohol use disorder and an application thereof, belonging to the technical field of health food. The composition of the invention is composed of dendrobium, polygonatum and kudzu root. The composition of the invention has significant protective effect on alcoholic liver injury in mice, including improving the morphology and structure of liver cells, improving liver function and liver lipid metabolism. On the other hand, the composition of the present invention can improve depression and anxiety-like reactions after alcohol withdrawal, reduce the elevation of corticotropin-releasing hormone, corticotropin and corticosterone caused by alcohol withdrawal; inhibit alcohol withdrawal Causes a decrease in the monoamine transmitters dopamine and norepinephrine.

Description

technical field [0001] The invention belongs to the technical field of health food, and in particular relates to a medicinal and edible homologous composition for alcohol use disorder and its application, including the protective effect on alcoholic liver injury and the new application on the withdrawal reaction after alcohol addiction . Background technique [0002] Excessive or chronic alcohol consumption can cause alcohol use disorder syndromes such as intoxication, addiction, and withdrawal symptoms. The safe drinking amount of alcohol is zero, and the World Health Organization has long listed alcohol as a first-class carcinogen. Alcoholics, on the other hand, experience severe withdrawal symptoms when they stop drinking, and more severe withdrawal symptoms when they resume drinking. [0003] After alcohol is absorbed, most of it is metabolized in the liver, and only about 5%-10% alcohol is not oxidized and decomposed, and is directly excreted from the urine or exhaled...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61P1/16A61P25/22A61P25/24A61P25/32A23L33/105
CPCA61K36/8984A61K36/8969A61K36/488A61P1/16A61P25/32A61P25/24A61P25/22A23L33/105A61K2236/331A61K2236/35A61K2236/53A23V2002/00A61K2300/00A23V2200/322A23V2200/31A23V2200/32
Inventor 姜波杨文惠修志龙虞诗强王银波陈建文
Owner DALIAN UNIV OF TECH
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