Anti-setd3 monoclonal antibody and use thereof

A monoclonal antibody and protein technology, applied in applications, anti-enzyme immunoglobulins, instruments, etc., to achieve good recognition specificity and strong recognition specificity
CN113637079BActive Publication Date: 2022-06-14WUHAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHAN UNIV
Publication Date
2022-06-14

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Abstract

The present invention provides an anti-SETD3 monoclonal antibody and its use. The monoclonal antibody can recognize SETD3 protein. The monoclonal antibody includes a heavy chain variable region and a light chain variable region: the heavy chain variable region The region has three complementary determining regions with the amino acid sequence shown in SEQ ID NO:1-SEQ ID NO:3; the light chain variable region has three complementary determining regions with the amino acid sequence shown in SEQ ID NO:4-SEQ ID NO:6. The anti-SETD3 monoclonal antibody provided by the present invention has good recognition specificity to in vitro purified protein, in vitro cultured mammalian cell exogenous SETD3 protein, and mouse tissue SETD3 protein; compared with commercially available antibodies, the monoclonal antibody recognizes more specific.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and relates to an anti-SETD3 monoclonal antibody and its application. Background technique

[0002] SETD3 is a member of the methyltransferase family containing the SET domain, which is close to SETD4 and SETD6 proteins in terms of kinship and structure. The secondary structure of SETD3 mainly includes catalytic domain (SET domain) and substrate binding domain (Rubis-subs-bind domain). SETD3 is relatively conserved in different species, and its homologous protein has not been found in yeast. In humans, SETD3 is expressed in a variety of tissues, with the highest expression in testis and skeletal muscle. In the process of myoblast differentiation, SETD3 can promote the differentiation of skeletal muscle; SETD3 and FoxM1 are combined in the promoter region of vascular endothelial growth factor (vascular endothelial-derived growth factor, VEGF) signaling pathway and negatively regulate the expression ...

Claims

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