A kind of early diagnosis marker of prostate cancer and its application
A technology for early diagnosis of prostate cancer, applied in the field of biomedicine, can solve the problem of lack of early molecular markers of prostate cancer
Active Publication Date: 2022-06-03
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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The main technical difficulty and difficulty at present is the lack of clear and diagnostic early molecular markers for the occurrence and development of prostate cancer
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[0028] As shown in Figure 2, by comparing the patients with low expression and high expression of GPRASP1, we found that the expression level of GPRASP1
[0033] In some embodiments, to further demonstrate the role of GPRASP1 in prostate cancer, we collected a
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The invention discloses an early diagnosis marker of prostate cancer and application thereof, wherein the early diagnosis marker of prostate cancer is methylation of GPRASP1 gene promoter. The present invention discovers for the first time that the differential expression of GPRASP1 gene in prostate cancer patients is closely related to the degree of methylation of the GPRASP1 promoter, and by detecting the expression level of the methylation of the GPRASP1 gene promoter, it can be judged whether the subject has prostate cancer Cancer, providing molecular means for the early diagnosis of prostate cancer.
Description
A kind of early diagnosis marker of prostate cancer and its application technical field The present invention relates to biomedical technology field, relate in particular to a kind of prostate cancer early diagnosis marker and its application use. Background technique With the acceleration of economic development and population aging process, cancer has become an important cause of serious harm to people's health. one of the diseases. According to the latest statistical report, worldwide, there are more than 19 million new cancer cases every year, The death toll from cancer has exceeded 9.95 million. In China, 4.13 million new cases of cancer are replaced every year. The death toll reached 2.62 million. In recent years, with the improvement of people's living standards, the aging of the population, and changes in the environment and diet, prostate cancer has The incidence in my country is increasing year by year. However, prostate cancer grows slowly in the ea...
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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/154C12Q2600/158
Inventor 张健卢奕林宇翰熊铭港常明黄昕曹烨
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA