Compound fenbendazole tablet and preparation method thereof
A technology of fenbendazole tablets and fenbendazole, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of low dissolution rate and poor therapeutic effect, and achieve high dissolution rate , low production cost, and many types of insect repellent effects
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Embodiment 1
[0036] Three batches of 1000 compound fenbendazole tablets were prepared according to the determined formula composition and preparation process.
[0037] The formula composition of each batch of compound fenbendazole tablets: fenbendazole 500mg, praziquantel 50mg, calcium carbonate 120mg, croscarmellose sodium 64mg, povidone k30 14.4mg, magnesium stearate 8mg and silicon dioxide 31mg.
[0038] The preparation process of compound recipe fenbendazole tablet:
[0039] The first step, dissolving povidone K30 in water or 10wt% ethanol aqueous solution is prepared into a 3wt% binder solution;
[0040] In the second step, the raw material of fenbendazole (ultrafine powder 150-250 mesh) and praziquantel raw material (100 mesh) and auxiliary materials (calcium carbonate, croscarmellose sodium, silicon dioxide) are placed in high-efficiency mixing The granulator mixes evenly;
[0041] The third step is to add the adhesive to the mixed powder running at high speed, stir to obtain soft ...
Embodiment 2
[0071] Prepare 1000 compound fenbendazole tablets according to the determined formula composition and preparation process.
[0072] The formula composition of each batch of compound fenbendazole tablets: fenbendazole 125mg, praziquantel 12.5mg, anhydrous calcium hydrogen phosphate 30mg, povidone K30 12mg, magnesium stearate 1.0mg and silicon dioxide 10mg.
[0073] The preparation process of compound recipe fenbendazole tablet:
[0074] The first step, dissolving povidone K30 in water or 50wt% ethanol aqueous solution is prepared into a 10wt% binder solution;
[0075] In the second step, the fenbendazole raw material (150-250 mesh ultrafine powder) and the praziquantel raw material (100 mesh) and auxiliary materials are placed in a high-efficiency mixing granulator and mixed evenly;
[0076] The third step is to add the adhesive to the mixed powder running at high speed, stir to obtain soft material, add the soft material to the oscillating granulator, and pass through a 18-me...
Embodiment 3
[0082] Prepare 1000 compound fenbendazole tablets according to the determined formula composition and preparation process.
[0083] The formula composition of each batch of compound fenbendazole tablets: fenbendazole 500mg, praziquantel 50mg, calcium sulfate 120mg, crospovidone 56mg, povidone K30 30mg, magnesium stearate 8mg.
[0084] The preparation process of compound recipe fenbendazole tablet:
[0085] The first step, dissolving povidone K30 in 20wt% ethanol aqueous solution is prepared into a 6wt% binder solution;
[0086] In the second step, the fenbendazole raw material (ultrafine powder 150-250 mesh) and praziquantel raw material (100 mesh) and auxiliary materials (calcium sulfate and crospovidone) are placed in a high-efficiency mixing granulator and mixed uniformly;
[0087] The third step is to add the binder into the high-speed mixed powder, stir to obtain soft material, add the soft material to the swing granulator, and pass through a 18-mesh sieve to obtain gran...
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