Half-brain asymmetric genetic structure drawing system and method for Alzheimer's disease

A technology of genetic structure and hemi-brain of silent disease, applied in the field of brain imaging genetic structure mapping, can solve the lack of complete mapping, the origin and formation mechanism of genes that hinder abnormal asymmetry, and the single genetic research method of hemi-brain asymmetry in AD patients And other issues

Active Publication Date: 2021-11-30
SHANDONG JIANZHU UNIV
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Problems solved by technology

[0004] At present, the genetic research on hemibrain asymmetry in AD patients based on magnetic resonance imaging mainly focuses on the structural phenotypes of the gray matter regions of the brain (cortical volume, cortical thickness, surface area, etc.), ignoring the influence of genes on brain connection characteristics, and on The genetic research method of hemibrain asymmetry in AD patients is relatively simple, and the genetic analysis of hemibrain asymmetry in AD patients has not been carried out from multiple dimensions. The complete mapping of the genetic structure of AD patients hinders the exploration of the genetic origin and formation mechanism of the abnormal asymmetry of brain connectivity in AD patients

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  • Half-brain asymmetric genetic structure drawing system and method for Alzheimer's disease
  • Half-brain asymmetric genetic structure drawing system and method for Alzheimer's disease

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Embodiment 1

[0037] refer to figure 1 , the present embodiment provides a genetic structure drawing system for Alzheimer's disease hemibrain asymmetry, which includes:

[0038] (1) Asymmetric brain connection extraction module, which is used to extract abnormal asymmetric brain connections based on the hemi-brain functional connectivity and hemi-brain white matter connectivity in the multimodal magnetic resonance images of the subject.

[0039] In the specific implementation, the subjects were obtained from international public databases such as the Alzheimer's Disease Neuroimaging Initiative (ADNI). Multimodal magnetic resonance images included sMRI images, fMRI images and dMRI images of the subjects.

[0040] In one or more embodiments, the genetic structure mapping system for Alzheimer's disease hemibrain asymmetry further includes:

[0041] The image preprocessing module is used for preprocessing the multimodal magnetic resonance images of the subjects.

[0042] Among them, the prep...

Embodiment 2

[0065] refer to figure 2 , the present embodiment provides a genetic structure drawing method for Alzheimer's disease hemibrain asymmetry, which includes:

[0066] Step 1: Based on the hemi-brain functional connectivity and hemi-brain white matter connectivity in the multi-modal magnetic resonance images of the subjects, extract abnormal asymmetric brain connections;

[0067] Step 2: Obtain the whole genome sequencing data of the subjects and perform quality control on single nucleotide polymorphisms;

[0068] Step 3: Estimate the hemispheric difference in the heritability of the connections in the left and right hemispheres, the heritability of the asymmetry coefficient, and the genetic correlation of the brain connections in the left and right hemispheres based on the abnormal asymmetry of the brain connections and the quality-controlled whole-genome sequencing data, and determine Abnormal genetic effects in AD patients;

[0069] Step 4: Based on the abnormal genetic effe...

Embodiment 3

[0075] This embodiment provides a computer-readable storage medium, on which a computer program is stored, and when the program is executed by a processor, the method for drawing the genetic structure of Alzheimer's disease hemibrain asymmetry as described in the second embodiment is realized in the steps.

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Abstract

The invention provides a heredity structure drawing system and a heredity structure drawing method for half-brain asymmetry of Alzheimer's disease. The system comprises an asymmetric brain connection extraction module which is used for extracting abnormal asymmetric brain connections based on half-brain function connections and half-brain white matter connections in a tested multi-mode magnetic resonance image; a genetic data processing module which is used for acquiring tested whole genome sequencing data and performing quality control on single nucleotide polymorphism; an abnormal genetic effect determination module which is used for estimating the hemisphere difference of the heredity of the connection in the left hemisphere and the right hemisphere, the heredity of the asymmetric coefficient and the genetic correlation of the brain connection of the left hemisphere and the right hemisphere, and determining the abnormal genetic effect of the AD patient; and a genetic structure drawing module which is used for projecting the estimated genetic degree and genetic correlation to a connecting brain region based on the abnormal genetic effect and the whole genome sequencing data after quality control, averaging the genetic degree of each brain region, and further drawing a genetic structure of abnormal asymmetry of the brain.

Description

technical field [0001] The invention belongs to the field of brain imaging genetic structure drawing, and in particular relates to a genetic structure drawing system and method for Alzheimer's disease hemibrain asymmetry. Background technique [0002] The statements in this section merely provide background information related to the present invention and do not necessarily constitute prior art. [0003] Magnetic resonance imaging provides technical means for exploring the asymmetry of the human brain and its genetic mechanism. In recent years, researchers have gradually realized the importance of characterizing brain connection patterns for understanding the asymmetry of the hemibrain in patients with Alzheimer's disease (AD). From the perspective of the circuit, we can deeply explore the differences in the left and right hemispheres of the brain connection patterns of AD patients, thus providing a new perspective for understanding brain lateralization. [0004] At presen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/40G06T7/11G06T7/00
CPCG16B20/40G06T7/11G06T7/0012G06T2207/10088G06T2207/30016
Inventor 魏珑刘振栋郝凡昌袭肖明
Owner SHANDONG JIANZHU UNIV
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