System and method for mapping genetic structure of Alzheimer's disease hemibrain asymmetry

Abstract

The invention provides a genetic structure drawing system and method for Alzheimer's disease hemibrain asymmetry. Among them, the system includes an asymmetric brain connection extraction module, which is used to extract abnormal asymmetric brain connections based on the hemi-brain functional connection and hemi-brain white matter connection in the multi-modal magnetic resonance images of the subjects; the genetic data processing module uses To obtain the whole genome sequencing data of the subjects and perform quality control on single nucleotide polymorphisms; the abnormal genetic effect determination module is used to estimate the hemispheric difference of the heritability of the connection in the left and right hemispheres, the heritability of the asymmetry coefficient and the left and right Genetic correlation of hemispheric brain connections, to determine the genetic effects of abnormalities in AD patients; genetic structure mapping module, used to project estimated heritability and genetic correlations to connections based on abnormal genetic effects and quality-controlled whole-genome sequencing data brain regions and average the heritability of each brain region to map the genetic architecture of abnormal brain asymmetries.

Description

technical field [0001] The invention belongs to the field of brain imaging genetic structure drawing, and in particular relates to a genetic structure drawing system and method for Alzheimer's disease hemibrain asymmetry. Background technique [0002] The statements in this section merely provide background information related to the present invention and do not necessarily constitute prior art. [0003] Magnetic resonance imaging provides technical means for exploring the asymmetry of the human brain and its genetic mechanism. In recent years, researchers have gradually realized the importance of characterizing brain connection patterns for understanding the asymmetry of the hemibrain in patients with Alzheimer's disease (AD). From the perspective of the circuit, we can deeply explore the differences in the left and right hemispheres of the brain connection patterns of AD patients, thus providing a new perspective for understanding brain lateralization. [0004] At presen...

AI Technical Summary

Problems solved by technology

[0004] At present, the genetic research on hemibrain asymmetry in AD patients based on magnetic resonance imaging mainly focuses on the structural phenotypes of the gray matter regions of the brain (cortical volume, cortical thickness, surface area, etc.), ignoring the influence of genes on brain connection characteristics, and on The genetic research method of hemibrain asymmetry in AD patients is relatively simple, and the genetic analysis of hemibrain asymmetry in AD patients has not been carried out from multiple dimensions. The complete mapping of the genetic structure of AD patients hinders the exploration of the genetic origin and formation mechanism of the abnormal asymmetry of brain connectivity in AD patients

Images