31 results about "Genetic correlation" patented technology

Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Genetic material from the target individual is acquired, amplified and the genetic data is measured using known methods. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment of the invention, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment of the invention, the chromosome copy number can be determined from the measured genetic data of a single or small number of cells, with or without genetic information from one or both parents. In another embodiment of the invention, these determinations are made for the purpose of embryo selection in the context of in-vitro fertilization. In another embodiment of the invention, the genetic data can be reconstructed for the purposes of making phenotypic predictions.

Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.

A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and / or genetic data taken from other related individuals.

A method for assessing susceptibility of a subject to a genetically related disease or condition relative to a general population. The method includes the steps of: determining the presence or absence of a plurality of risk factors associated with the subject and having a correlation with the disease or condition; assigning a risk score, to each of the selected risk factors determined to be present, based upon a strength of correlation assigned to the factor with respect to the disease or condition; and combining the risk scores to calculate an overall susceptibility score, wherein the overall susceptibility score represents susceptibility of the subject to the disease or condition in relation to a base score representing the risk that a member of the general population will have the disease or condition without consideration of risk factors. The risk factors require the inclusion of at least two of age, gender, race, and family history and require the inclusion of a plurality of polymorphisms selected for known correlation with the disease or condition.

A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and / or genetic data taken from other related individuals.

Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.

Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.

Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.

Systems, methods, and apparatus for large scale, high throughput phenotyping of items including plants to derive environment / genetics correlations based on controlled variation of environment. Spatial and temporal resolution is improved by an integrated system that can use space efficiently yet concurrently process a large number of replicates but in varying environments. This is accomplished by using an array of miniature greenhouses, each in communication with one or more generators or regulators of an environmental factor that can be independently supplied and controlled to each miniature greenhouse. The controller also controls acquisition of data from each greenhouse as well as processing of that data into phenomic / genomic correlations.

The present invention relates to transgenic vertebrate, including mammalian, cells, whose genomes comprise one or more elements of the piggyBac family transposon system. Transgenic non-human vertebrates, including transgenic non-human mammals, whose genomes comprise one or more elements of the piggyBac family transposon system, are also provided. Methods of making and using the cells and animals of the invention, including applications in the medical, veterinary, and agricultural fields, are additionally provided. The present invention also relates to kits useful for practicing such methods.

The invention discloses a breeding method for a shellfish meat trait new strain. The breeding method comprises the following steps: firstly constructing more than 20 full-sib and / or half-sib families, and breeding all the families in different sea areas; performing meat trait index measurement and apparent index measurement on all the bred families; then screening out meat trait indexes with the heritability larger than 0.2, and screening out indexes with the genetic correlation absolute value larger than 0.5 between the meat trait indexes and the appearance indexes; screening out candidate parent families according to the retention rate of 20 percent, and selecting optimal individuals from the candidate parent families to be used as reproduction parents according to the appearance trait indexes; finally carrying out generational breeding according to the breeding method, and finally forming the new strain with high meat trait index. According to the breeding method, on the premise that a research object is not dissected, a method of combining family selection and within-family selection is adopted for breeding the meat trait index from the directly measurable appearance indexes by indirect breeding.

The invention provides a cerebral apoplexy pharmacy and genetic correlation detection method. According to the detection method, primers and probes are synthesized through four polymorphic sites of two genes of cytochrome P450CYP2C19*2: rs4244285, CYP2C19*3: rs4986893, CYP2C19*17: rs12248560, and SVIL: rs17834991, real-time fluorescence quantification allele probe detection is implemented, and whether a target belongs to pharmacy susceptible populations or not can be judged. By adopting the method, clinical pharmacy schemes can be instructed and adjusted, bases can be made for clinical individual treatment, and adverse reactions of medicines are prevented. The method is capable of simultaneously detecting four polymorphic sites and has the advantages of being simple and convenient, accurate, rapid, high in flux and the like.

The invention discloses a selection method for excellent individuals of Chinese firs. The selection method is a mixed linear model method, utilizes a spatial analysis method for estimating a spatial residual variance and spatial autocorrelation, utilizes a restrictive maximum likelihood method for estimating a genetic variance, and utilizes best linear unbiased prediction for individual breeding value of the Chinese firs. The method analyzes genetic variation, genetic control and genetic correlation among characters for main economic characters such as tree height, diameter at breast height, wood basic density, micro fiber angle and the like of the Chinese fir, predicts the breeding value of each character for each individual of the Chinese firs, and according to a multi-character index selection formula of the Chinese fir, picks out individuals which are genetically excellent both in growth and wood property. According to the method, when the environmental impact is eliminated in generic parameter estimation, the multi-character index selection based on the breeding value can select the individuals with generically excellent comprehensive characters effectively, the accuracy is high, and the selected excellent individuals can serve as both the material for asexual reproduction of the Chinese firs and the breeding material for next-generation breeding population of the Chinese firs.

The invention discloses a serum biochemical marker for auxiliary screening of low-fat meat chickens and application of the serum biochemical marker, and belongs to the technical field of genetic breeding of poultry. The serum biochemical marker provided by the invention is the HDL-C / LDL-C level in chicken serum. Such serum biochemical markers in low-fat meat chickens and high-fat meat chickens have significant differences, also have high genetic correlation coefficients and heritability and can be used for identification of abdominal fat of meat chicken and breading of low-fat meat chickens. Besides, the invention further provides application and a screening method of the serum biochemical marker.

Described are methods for identification of likelihood of health outcomes such as the development of a medical condition using health histories from genetically related individuals. Embodiments include: receiving a first set of genetic data associated with the human subject; comparing the first set of genetic data to a plurality of sets of genetic data from a plurality of other individuals; identifying from the comparison a family network comprising individuals genetically related to the human subject as defined by identity by descent; receiving a set of health history data for each individual and each individual in the family network; analyzing the set of health history data to generate a health outcome score for the human subject, the health outcome score being a measure of risk for the human subject to develop a pre-defined health outcome that is associated with the health outcome score; and reporting the health outcome score.

The invention relates to a selection method capable of simultaneously improving feed efficiency and increasing growth speed of pigs. The selection method is characterized in that the selection methodfor simultaneously improving the feed efficiency and increasing growth speed of pigs by utilizing over-growth body weight traits comprises the steps of selection of basic conditions, determination ofindexes and data processing, breeding value estimation, comprehensive selection index calculation, and reserve breeding pig selection, matching and verification. The selection method is simple and practical, is good in selection effect, can be used for phenotypic selection of simultaneous determination groups, can be used for comparing and selecting different determination groups according to heritability and genetic correlation, and can be used for directly selectively improving the feed efficiency and increasing the growth speed of pig groups.

The invention discloses a molecular marker-assisted breeding method of a new variety for rapid growth of trachinotus ovatus. According to the method, by efficiently integrating technologies such as individual phenotype value selection, microsatellite molecular marker, additive genetic correlation matrix, linear hybrid model, quantity genetics, individual breeding value selection, gender specific molecular marker, inter-individual genetic distance analysis, group mating scheme and the like, the problems of slow fry growth, low survival rate, poor stress resistance and disease resistance, germplasm degeneration and the like caused by difficulty in candidate parent genetic evaluation and optimal selection and blind inbreeding due to unclear genetic relationship and sex in existing trachinotus ovatus genetic breeding work can be effectively solved.

The present invention provides methods and apparatus for generating human readable output with a correlation between one or more genetic traits and one or more medicaments.

A method for identifying two or more infections as related or non-related infections based on an estimated genetic relatedness of the two or more infections, comprising: (i) receiving, for each of two or more infected patients, infection-relevant information comprising an antibiotic resistance profile for the patient's infection, a geo-temporal record for the patient, and a caregiver history for the patient; (ii) estimating, using a trained genetic relatedness model, a genetic relatedness of at least two of the two or more infections; (iii) comparing the estimated genetic relatedness between at least two of the two or more infections to a predetermined threshold; (iv) identifying, based on the comparison, the at least two of the two or more infections as a related infection or a non-related infection.

The invention provides an oval pompano body mass breeding method based on a Gompertz model. The method includes the steps: measuring multiple body mass data of an oval pompano breeding group; buildinga Gompertz model of body mass of each pompano body; calculating an optimal value of body mass growth velocity of each pompano body; calculating an breeding value of body mass growth velocity of eachpompano body according to a additive genetic correlation matrix constructed by a micro-satellite marker; selecting and remaining candidate parents according to the breeding values of the body mass growth velocity, and designing mating schemes of the candidate parents to complete oval pompano body mass breeding. According to the method, new strains of rapid growth of oval pompano can be cultured, consanguineous mating is avoided, and breeding efficiency is improved.

The invention provides a method for breeding a new red rice variety by using medicinal wild rice, and belongs to the technical field of rice breeding. The method for breeding the new red rice variety by using the medicinal wild rice comprises the following steps: introducing DNA of the medicinal wild rice into receptor rice, bagging before flowering of the receptor rice, harvesting seeds after maturation, planting the seeds in the current year, screening after heading to obtain excellent single plants, and subsequently planting twice every year, early planting is excellent single plants obtained by screening of late planting in the last year, late planting is excellent single plants obtained by screening of early planting in the current year, and so on until single plants with stable characters are obtained; the genetic correlation between a single plant with stable characters and the medicinal wild rice is verified by adopting an SSR marker, and if a specific DNA fragment of the medicinal wild rice is amplified from the single plant with stable characters and a corresponding fragment cannot be amplified from receptor rice, the breeding is successful. The method disclosed by the invention can be used for rapidly breeding a new red rice variety with medicinal wild rice gene polymerization.

The invention discloses a breeding method and device for improving the number of weaned piglets and a medium, and relates to the technical field of pig breeding. The breeding method comprises the steps of determining evaluation standards suitable for a healthy piglet number character; obtaining the healthy piglet rate according to the healthy piglet number and the total number born; respectively determining estimated breeding values of the healthy piglet number and the healthy piglet rate, and carrying out standardization; respectively setting weighting weighted values of the healthy piglet number breeding value and the healthy piglet rate breeding value, taking the weighted sum of the standardized healthy piglet number breeding value and the standardized healthy piglet rate breeding valueas a selection index of a litter size character, and selecting maternal pig litter size characters according to the selection index. The breeding method explores the genetic correlation influences imposed by different birth weight selection standards on the piglet number and other breeding characters, simultaneously takes the healthy piglet number and the healthy piglet rate into breeding character selection indexes, and has the effects of reducing invalid piglet number, improving the valid piglet number and finally improving the number of weaned piglets.

The invention discloses a selection method for excellent individuals of Chinese firs. The selection method is a mixed linear model method, utilizes a spatial analysis method for estimating a spatial residual variance and spatial autocorrelation, utilizes a restrictive maximum likelihood method for estimating a genetic variance, and utilizes best linear unbiased prediction for individual breeding value of the Chinese firs. The method analyzes genetic variation, genetic control and genetic correlation among characters for main economic characters such as tree height, diameter at breast height, wood basic density, micro fiber angle and the like of the Chinese fir, predicts the breeding value of each character for each individual of the Chinese firs, and according to a multi-character index selection formula of the Chinese fir, picks out individuals which are genetically excellent both in growth and wood property. According to the method, when the environmental impact is eliminated in generic parameter estimation, the multi-character index selection based on the breeding value can select the individuals with generically excellent comprehensive characters effectively, the accuracy is high, and the selected excellent individuals can serve as both the material for asexual reproduction of the Chinese firs and the breeding material for next-generation breeding population of the Chinese firs.

The invention discloses a serum biochemical marker for auxiliary screening of low-fat broiler chicken and application of a serum biochemical marker, and belongs to the technical field of poultry genetic breeding. The serum biochemical marker disclosed by the invention is the level of HDL-C / LDL-C in chicken serum. The marker has significant difference in the low-fat broiler chicken and high-fat broiler chicken, also has high genetic correlation coefficient and hereditary capacity, and can be applied to identification of abdominal fat amount of the broiler chicken and breeding of the low-fat broiler chicken. In addition, the invention also provides the application and a screening method of the serum biochemical marker.

Described are methods for identification of likelihood of health outcomes such as the development of a medical condition using health histories from genetically related individuals. Embodiments include: receiving a first set of genetic data associated with the human subject; comparing the first set of genetic data to a plurality of sets of genetic data from a plurality of other individuals; identifying from the comparison a family network comprising individuals genetically related to the human subject as defined by identity by descent; receiving a set of health history data for each individual and each individual in the family network; analyzing the set of health history data to generate a health outcome score for the human subject, the health outcome score being a measure of risk for the human subject to develop a pre-defined health outcome that is associated with the health outcome score; and reporting the health outcome score.

Disclosed are methods for testing biological samples containing genomic nucleic acids obtained from an organism having a genome, such as a human genome. It is often desirable to analyze a DNA sample or more than one, different DNA samples, to determine whether the sample comes from one individual or two individuals. The present method requires very low amounts of DNA and can use partial sequences of DNA fragments. Partial sequences are analyzed for the presence of polymorphisms (e.g. SNP's) that can be mapped to a reference SNP map. The distance between similar SNPS, which are genetically linked, can be used to statistically determine a likelihood of identity of individuality in a sample.

The invention relates to a method for evaluating the semen grade of Bashang long-tail breeder cocks, the method comprises steps of respectively giving different weighted values according to the influence of sperm motility, sperm collection quantity and sperm concentration on cock breeder value, hen fertilization rate and hereditary characteristics of cocks, and synthesizing the weighted values into a breeder cock semen grade index, namely a breeder cock semen grade index, wherein the breeder cock semen grade index is equal to 58.42*semen collection quantity+78.55*sperm motility+1.48*sperm concentration, and evaluating the reproductive performance of the breeder cock according to the breeder cock semen grade index. Because the breeder cock semen grade index is in strong positive genetic correlation with the semen quality, the quality of the long-tailed breeding cock semen on the dam is judged according to the genetic correlation, selection and retention are judged, the quality of the semen is objectively evaluated, the selection accuracy and operability are improved, the quality of the breeding cock semen can be improved generation by generation according to the selection, the genetic progress of breeder cock selection is accelerated, so that the reproductive performance, the breeding value and the economic benefit of the long-tail chickens on the dam are improved.

The invention provides a genetic structure drawing system and method for Alzheimer's disease hemibrain asymmetry. Among them, the system includes an asymmetric brain connection extraction module, which is used to extract abnormal asymmetric brain connections based on the hemi-brain functional connection and hemi-brain white matter connection in the multi-modal magnetic resonance images of the subjects; the genetic data processing module uses To obtain the whole genome sequencing data of the subjects and perform quality control on single nucleotide polymorphisms; the abnormal genetic effect determination module is used to estimate the hemispheric difference of the heritability of the connection in the left and right hemispheres, the heritability of the asymmetry coefficient and the left and right Genetic correlation of hemispheric brain connections, to determine the genetic effects of abnormalities in AD patients; genetic structure mapping module, used to project estimated heritability and genetic correlations to connections based on abnormal genetic effects and quality-controlled whole-genome sequencing data brain regions and average the heritability of each brain region to map the genetic architecture of abnormal brain asymmetries.

The invention provides a body mass breeding method for pomfret ovata based on the Gompertz model, which measures the multiple body weight data of the breeding population of pomfret ovata, establishes the Gompertz model of the body weight of each fish, and calculates the body mass of each fish Based on the optimal value of body weight growth rate, combined with the additive genetic correlation matrix constructed by microsatellite markers, the breeding value of body weight growth rate of each fish is calculated, and candidate parents are selected according to the breeding value of body weight growth rate, and candidate parents are designed The mating program, to complete the body quality breeding of oval pomfret. The method of the invention can breed a new fast-growing strain of the oval pomfret, avoid inbreeding, and improve breeding efficiency.