31 results about "Genetic correlation" patented technology

A method for assessing susceptibility of a subject to a genetically related disease or condition relative to a general population. The method includes the steps of: determining the presence or absence of a plurality of risk factors associated with the subject and having a correlation with the disease or condition; assigning a risk score, to each of the selected risk factors determined to be present, based upon a strength of correlation assigned to the factor with respect to the disease or condition; and combining the risk scores to calculate an overall susceptibility score, wherein the overall susceptibility score represents susceptibility of the subject to the disease or condition in relation to a base score representing the risk that a member of the general population will have the disease or condition without consideration of risk factors. The risk factors require the inclusion of at least two of age, gender, race, and family history and require the inclusion of a plurality of polymorphisms selected for known correlation with the disease or condition.

Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.

The invention provides a cerebral apoplexy pharmacy and genetic correlation detection method. According to the detection method, primers and probes are synthesized through four polymorphic sites of two genes of cytochrome P450CYP2C19*2: rs4244285, CYP2C19*3: rs4986893, CYP2C19*17: rs12248560, and SVIL: rs17834991, real-time fluorescence quantification allele probe detection is implemented, and whether a target belongs to pharmacy susceptible populations or not can be judged. By adopting the method, clinical pharmacy schemes can be instructed and adjusted, bases can be made for clinical individual treatment, and adverse reactions of medicines are prevented. The method is capable of simultaneously detecting four polymorphic sites and has the advantages of being simple and convenient, accurate, rapid, high in flux and the like.

The invention discloses a selection method for excellent individuals of Chinese firs. The selection method is a mixed linear model method, utilizes a spatial analysis method for estimating a spatial residual variance and spatial autocorrelation, utilizes a restrictive maximum likelihood method for estimating a genetic variance, and utilizes best linear unbiased prediction for individual breeding value of the Chinese firs. The method analyzes genetic variation, genetic control and genetic correlation among characters for main economic characters such as tree height, diameter at breast height, wood basic density, micro fiber angle and the like of the Chinese fir, predicts the breeding value of each character for each individual of the Chinese firs, and according to a multi-character index selection formula of the Chinese fir, picks out individuals which are genetically excellent both in growth and wood property. According to the method, when the environmental impact is eliminated in generic parameter estimation, the multi-character index selection based on the breeding value can select the individuals with generically excellent comprehensive characters effectively, the accuracy is high, and the selected excellent individuals can serve as both the material for asexual reproduction of the Chinese firs and the breeding material for next-generation breeding population of the Chinese firs.

The invention relates to a selection method capable of simultaneously improving feed efficiency and increasing growth speed of pigs. The selection method is characterized in that the selection methodfor simultaneously improving the feed efficiency and increasing growth speed of pigs by utilizing over-growth body weight traits comprises the steps of selection of basic conditions, determination ofindexes and data processing, breeding value estimation, comprehensive selection index calculation, and reserve breeding pig selection, matching and verification. The selection method is simple and practical, is good in selection effect, can be used for phenotypic selection of simultaneous determination groups, can be used for comparing and selecting different determination groups according to heritability and genetic correlation, and can be used for directly selectively improving the feed efficiency and increasing the growth speed of pig groups.

The invention discloses a molecular marker-assisted breeding method of a new variety for rapid growth of trachinotus ovatus. According to the method, by efficiently integrating technologies such as individual phenotype value selection, microsatellite molecular marker, additive genetic correlation matrix, linear hybrid model, quantity genetics, individual breeding value selection, gender specific molecular marker, inter-individual genetic distance analysis, group mating scheme and the like, the problems of slow fry growth, low survival rate, poor stress resistance and disease resistance, germplasm degeneration and the like caused by difficulty in candidate parent genetic evaluation and optimal selection and blind inbreeding due to unclear genetic relationship and sex in existing trachinotus ovatus genetic breeding work can be effectively solved.

The present invention provides methods and apparatus for generating human readable output with a correlation between one or more genetic traits and one or more medicaments.

The invention provides an oval pompano body mass breeding method based on a Gompertz model. The method includes the steps: measuring multiple body mass data of an oval pompano breeding group; buildinga Gompertz model of body mass of each pompano body; calculating an optimal value of body mass growth velocity of each pompano body; calculating an breeding value of body mass growth velocity of eachpompano body according to a additive genetic correlation matrix constructed by a micro-satellite marker; selecting and remaining candidate parents according to the breeding values of the body mass growth velocity, and designing mating schemes of the candidate parents to complete oval pompano body mass breeding. According to the method, new strains of rapid growth of oval pompano can be cultured, consanguineous mating is avoided, and breeding efficiency is improved.

The invention provides a method for breeding a new red rice variety by using medicinal wild rice, and belongs to the technical field of rice breeding. The method for breeding the new red rice variety by using the medicinal wild rice comprises the following steps: introducing DNA of the medicinal wild rice into receptor rice, bagging before flowering of the receptor rice, harvesting seeds after maturation, planting the seeds in the current year, screening after heading to obtain excellent single plants, and subsequently planting twice every year, early planting is excellent single plants obtained by screening of late planting in the last year, late planting is excellent single plants obtained by screening of early planting in the current year, and so on until single plants with stable characters are obtained; the genetic correlation between a single plant with stable characters and the medicinal wild rice is verified by adopting an SSR marker, and if a specific DNA fragment of the medicinal wild rice is amplified from the single plant with stable characters and a corresponding fragment cannot be amplified from receptor rice, the breeding is successful. The method disclosed by the invention can be used for rapidly breeding a new red rice variety with medicinal wild rice gene polymerization.

The invention discloses a breeding method and device for improving the number of weaned piglets and a medium, and relates to the technical field of pig breeding. The breeding method comprises the steps of determining evaluation standards suitable for a healthy piglet number character; obtaining the healthy piglet rate according to the healthy piglet number and the total number born; respectively determining estimated breeding values of the healthy piglet number and the healthy piglet rate, and carrying out standardization; respectively setting weighting weighted values of the healthy piglet number breeding value and the healthy piglet rate breeding value, taking the weighted sum of the standardized healthy piglet number breeding value and the standardized healthy piglet rate breeding valueas a selection index of a litter size character, and selecting maternal pig litter size characters according to the selection index. The breeding method explores the genetic correlation influences imposed by different birth weight selection standards on the piglet number and other breeding characters, simultaneously takes the healthy piglet number and the healthy piglet rate into breeding character selection indexes, and has the effects of reducing invalid piglet number, improving the valid piglet number and finally improving the number of weaned piglets.

The invention relates to a method for evaluating the semen grade of Bashang long-tail breeder cocks, the method comprises steps of respectively giving different weighted values according to the influence of sperm motility, sperm collection quantity and sperm concentration on cock breeder value, hen fertilization rate and hereditary characteristics of cocks, and synthesizing the weighted values into a breeder cock semen grade index, namely a breeder cock semen grade index, wherein the breeder cock semen grade index is equal to 58.42*semen collection quantity+78.55*sperm motility+1.48*sperm concentration, and evaluating the reproductive performance of the breeder cock according to the breeder cock semen grade index. Because the breeder cock semen grade index is in strong positive genetic correlation with the semen quality, the quality of the long-tailed breeding cock semen on the dam is judged according to the genetic correlation, selection and retention are judged, the quality of the semen is objectively evaluated, the selection accuracy and operability are improved, the quality of the breeding cock semen can be improved generation by generation according to the selection, the genetic progress of breeder cock selection is accelerated, so that the reproductive performance, the breeding value and the economic benefit of the long-tail chickens on the dam are improved.