Electrospray ion source device without auxiliary gas cylinder

Abstract

The invention relates to the technical field of mass spectrometric detection, and discloses an electrospray ion source device without an auxiliary gas cylinder. The electrospray ion source device comprises a peristaltic pump, an injector, an electrophoresis capillary tube, a metal spray needle, an ionization voltage source and a negative pressure ionization chamber; the metal spray needle is fixed in the negative pressure ionization chamber and is connected to one end of the electrophoresis capillary tube; the injector is connected with the electrophoresis capillary tube, and the peristaltic pump pushes a sample solution in the injector to enter the electrophoresis capillary tube and reach the metal spray needle; the ionization voltage source is electrically connected with the metal spray needle; the negative pressure ionization chamber is provided with an in-chamber air pressure regulating valve; and a mass spectrum sample inlet is formed in the negative pressure ionization chamber opposite to the metal spray needle. According to the electrospray ion source device, electrospray can be realized without an additional auxiliary gas cylinder, the system complexity is remarkably reduced, the ionization efficiency is high, the anti-pollution robustness is high, and the functions of a miniature mass spectrometer are expanded while the miniaturization of the miniature mass spectrometer is facilitated.

Description

technical field [0001] The invention relates to the technical field of mass spectrometry detection, in particular to an electrospray ion source device without an auxiliary gas cylinder. Background technique [0002] As a quantitative and qualitative highly sensitive chemical analysis method, mass spectrometry has been widely used in the field of analysis and detection. A mass spectrometry system usually consists of an ion source, a transmission system, and a mass analysis system. Electrospray ionization (Electrospray Ionization, ESI) technology can detect non-volatile and thermally unstable samples and macromolecular samples, and its soft ionization characteristics make the detection and analysis of macromolecules such as proteins a possible. Electrospray ionization technology is mainly used in liquid chromatography-mass spectrometry devices. At large liquid flow rates, in order to assist atomization and desolvation, additional gas cylinders must be added to provide atomiz...

AI Technical Summary

Problems solved by technology

Electrospray ionization technology is mainly used in liquid chromatography-mass spectrometry devices. At large liquid flow rates, in order to assist atomization and desolvation, additional gas cylinders must be added to provide atomization gas and drying gas. , the addition of additional cylinders makes the electrospray ionization device bulky and not easily compatible with other open ionization methods

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