Preparation method of visual antibacterial and anti-inflammatory dressing for bacterial infection wound treatment

A technology for bacterial infection and wounds, applied in bandages, absorbent pads, medical science and other directions, can solve problems such as unsolved problems, membrane damage, bacterial death, etc., to achieve antibacterial, anti-inflammatory and healing, reduce crystallinity, and promote healing. effect of action

Active Publication Date: 2022-08-05
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no effective clinical dressing for bacterial infection wounds. Positively charged cationic polymers can cause membrane damage and bacterial death, which has attracted the attention of researchers. However, how to optimize the bactericidal performance of hydrogel dressings based on In terms of improving the adhesion and light transmittance of hydrogel dressings, it has not been effectively solved

Method used

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  • Preparation method of visual antibacterial and anti-inflammatory dressing for bacterial infection wound treatment
  • Preparation method of visual antibacterial and anti-inflammatory dressing for bacterial infection wound treatment
  • Preparation method of visual antibacterial and anti-inflammatory dressing for bacterial infection wound treatment

Examples

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Embodiment 1

[0045] The present embodiment provides a preparation method of a visible antibacterial and anti-inflammatory dressing for bacterial infection type wound treatment, comprising the following steps:

[0046] Step 1, under the temperature condition of 80 ℃, dissolve polyvinyl alcohol and borax in water until it is completely clear to obtain mixed solution I; in the mixed solution I, the mass percentage of polyvinyl alcohol is 9%, and the mass percentage of borax is The fractional content is 5%; the number-average molecular weight of the polyvinyl alcohol is 80,000, and the relative molecular weight of the borax is 300;

[0047]Step 2, under normal temperature conditions, dissolve 1-vinyl-3-butylimidazolium bromide and ammonium persulfate in water until completely clear to obtain mixed solution II; in the mixed solution II, 1-vinyl-3 - The mass percentage of butylimidazolium bromide is 5%, and the mass percentage of ammonium persulfate is 0.2%; the molecular weight of the 1-vinyl-3...

Embodiment 2

[0084] The present embodiment provides a preparation method of a visible antibacterial and anti-inflammatory dressing for bacterial infection type wound treatment, comprising the following steps:

[0085] Step 1, under the temperature condition of 100 ℃, dissolve polyvinyl alcohol and borax in water until completely clear to obtain mixed solution I; in the mixed solution I, the mass percentage of polyvinyl alcohol is 4%, and the mass of borax is 100% The fractional content is 3%; the number-average molecular weight of the polyvinyl alcohol is 100,000, and the relative molecular weight of the borax is 400;

[0086] Step 2, under normal temperature conditions, dissolve 1-vinyl-3-butylimidazolium bromide and ammonium persulfate in water until completely clear to obtain mixed solution II; in the mixed solution II, 1-vinyl-3 - The mass percentage of butylimidazolium bromide is 12%, and the mass percentage of ammonium persulfate is 0.8%; the molecular weight of the 1-vinyl-3-butylim...

Embodiment 3

[0093] The present embodiment provides a preparation method of a visible antibacterial and anti-inflammatory dressing for bacterial infection type wound treatment, comprising the following steps:

[0094] Step 1, under the temperature condition of 70 ℃, dissolve polyvinyl alcohol and borax in water until it is completely clear to obtain mixed solution I; in the mixed solution I, the mass percentage of polyvinyl alcohol is 15%, and the mass of borax is The fractional content is 7%; the number-average molecular weight of the polyvinyl alcohol is 95,000, and the relative molecular weight of the borax is 450;

[0095] Step 2, under normal temperature conditions, dissolve 1-vinyl-3-butylimidazolium bromide and ammonium persulfate in water until completely clear to obtain mixed solution II; in the mixed solution II, 1-vinyl-3 - The mass percentage of butylimidazolium bromide is 10%, and the mass percentage of ammonium persulfate is 0.5%; the molecular weight of the 1-vinyl-3-butylim...

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Abstract

The invention discloses a preparation method of a visualized antibacterial and anti-inflammatory dressing for bacterial infection type wound treatment, comprising the following steps: step 1, dissolving polyvinyl alcohol and borax in water to obtain a mixed solution I; ‑Butylimidazolium bromide and ammonium persulfate are dissolved in water to obtain mixed solution II; step 3, nitrogen is introduced into mixed solution II; step 4, mixed solution II is subjected to a polymerization reaction after nitrogen is introduced to obtain a polyionic liquid Solution II; step 5, mixing the mixed solution I with the polyionic liquid solution II to obtain a dressing preparation solution; step 6, pouring the dressing preparation solution into a mold, and performing cyclic low-temperature freezing treatment to obtain a visualized antibacterial and anti-inflammatory dressing. The visualized antibacterial and anti-inflammatory dressing prepared by the method has the advantages of high light transmittance, excellent antibacterial performance and anti-inflammatory performance, good skin adhesion and self-healing performance, and has a good promoting effect on the healing of bacterial infection wounds. Features.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a preparation method of a visible antibacterial and anti-inflammatory dressing for bacterial infection type wound treatment. Background technique [0002] Common manifestations of bacterial infection in wounds include local redness and swelling, increased skin temperature, accompanied by a certain pain or swelling, and severe jumping pain, which affects the patient's normal life and sleep. Bacterial infection of wounds seriously delays the healing process, and if not treated in time, it may lead to sepsis, toxemia, septic shock, and even life-threatening. [0003] The wound healing process can be divided into four steps: hemostasis, inflammation, proliferation and remodeling. Following an injury, the skin's epidermal barrier breaks down, and the injured area becomes a breeding ground for bacterial growth and infection, disrupting the healing process. To...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/24A61L15/18A61L15/20A61L15/42A61L15/44A61L15/46C08F126/06C08F4/30
CPCA61L15/24A61L15/18A61L15/20A61L15/42A61L15/44A61L15/46C08F126/06C08F4/30A61L2300/404A61L2300/412A61L2300/41A61L2300/202C08L29/04
Inventor 朱晨辉范代娣刘斌傅容湛邓建军
Owner NORTHWEST UNIV
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