Sleep-promoting compound and application thereof

A compound, sleep-promoting technology, applied in drug combinations, plant raw materials, medical preparations containing active ingredients, etc., can solve problems such as after-effects, dependence, rebound insomnia, etc. Effect

Pending Publication Date: 2021-12-24
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology describes how certain chemicals called semensin or melatonins can stimulate people' s ability to fall back quickly when they are tired from work (sleep). These molecules have been found effective at promoting good healthy behavior during these times but it does little for those who don’t like them because their body doesn't produce enough hormone that helps with falling down again later on afterward)

Problems solved by technology

This patented technical problem addressed in this patents is finding new compounds from plants called zizyperoxides (ZP), which can be useful treatments for various diseases like insomnias caused by stressors or anxiety without causing negative side effects.

Method used

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  • Sleep-promoting compound and application thereof
  • Sleep-promoting compound and application thereof
  • Sleep-promoting compound and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A sleep-promoting complex made from:

[0019] (1) Mix casein and distilled water at a weight ratio of 1:10, add 0.5% trypsin to cow's milk casein for hydrolysis for 5 hours, then adjust the pH value to 5-6, centrifuge to get the supernatant, and then The obtained supernatant was inactivated by high temperature, then centrifuged to collect the supernatant, and freeze-dried to obtain the milk-derived casein hydrolyzate, which was stored at -20°C for later use; the obtained milk-derived casein hydrolyzate was concentrated by rotary evaporation to obtain saturated milk polypeptide The water sample was vacuum spray-dried to obtain milk casein sleep-promoting peptide powder, which was refrigerated at 4°C for later use;

[0020] (2) After cleaning and removing impurities, the wild jujube kernels are crushed, passed through a 20-mesh sieve, and then added to a 50 L extraction kettle of a continuous phase change extraction device. Under the conditions of 70% (volume) ethanol fo...

Embodiment 2

[0073] A sleep-promoting compound, except the following steps are the same as the preparation method of the examples:

[0074] (4) Prepare according to the following weight percentages: 5% bovine milk casein sleep-stimulating peptide, 50% wild jujube seed extract and 45% lily extract, and compound and mix within this ratio range to obtain the sleep-stimulating compound of the present invention.

Embodiment 3

[0076] A sleep-promoting compound, except the following steps are the same as the preparation method of the examples:

[0077] (4) Prepare according to the following weight percentages: 60% of bovine milk casein sleep-promoting peptide, 5% of jujube seed extract and 35% of lily extract, and compound and mix within this ratio range to obtain the sleep-promoting compound of the present invention.

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Abstract

The invention belongs to the technical field of extraction and application of milk-derived active ingredients. The sleep-promoting compound is prepared by compounding and mixing 5-60% of bovine casein sleep-promoting peptide, 5-50% of a spina date seed extract and 5-50% of a lily extract in the proportion range. The compound has a relatively good sleep-promoting effect, can reduce the content of awakening substances 5-HT and DA in plasma, and exerts the sleep-promoting effect without affecting the NE level in the plasma.

Description

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Claims

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Application Information

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OwnerSOUTH CHINA AGRI UNIV