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Roxadustat pharmaceutical preparation

A technology for roxadustat and pharmaceutical preparations, which is applied in the field of pharmaceutical preparations and can solve problems such as poor dissolution effect and poor water solubility of roxadustat

Active Publication Date: 2021-12-31
BEIJING WINSUNNY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention provides a pharmaceutical preparation of roxadustat, which aims to overcome the problems of poor water solubility and poor dissolution effect of roxadustat

Method used

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  • Roxadustat pharmaceutical preparation
  • Roxadustat pharmaceutical preparation
  • Roxadustat pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] composition Dosage (g) Roxadustat 50 Hydroxypropyl-β-cyclodextrin 80 Polacrilin Potassium 6 lactose 170 microcrystalline cellulose 43 Croscarmellose Sodium 7

[0030] Roxadustat d0.9=18μm

[0031] Preparation:

[0032] (1) Roxadustat, hydroxypropyl-β-cyclodextrin, polacrilin potassium, lactose, microcrystalline cellulose, and croscarmellose sodium are mixed uniformly to prepare a mixture;

[0033] (2) Adding purified water to the mixture in step (1), granulating and sizing to obtain drug granules;

[0034] (3) Compressing the drug granules into tablets.

Embodiment 2

[0036] composition Dosage (g) Roxadustat 100 Hydroxypropyl-β-cyclodextrin 50 Polacrilin Potassium 8 lactose 200 microcrystalline cellulose 30 Croscarmellose Sodium 8

[0037] Roxadustat d0.9=15μm

[0038] The preparation method is the same as in Example 1.

Embodiment 3

[0040] composition Dosage (g) Roxadustat 20 Hydroxypropyl-β-cyclodextrin 100 Polacrilin Potassium 3 lactose 120 microcrystalline cellulose 50 Croscarmellose Sodium 3

[0041] Roxadustat d0.9=20μm

[0042] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a roxadustat pharmaceutical preparation. The pharmaceutical preparation specifically comprises roxadustat, a cyclodextrin derivative, polacrilin potassium, a diluent and a disintegrating agent. The particle size d0.9 of the roxadustat is not greater than 30 [mu] m. The roxadustat pharmaceutical preparation prepared by the invention has better dissolution rate, thereby ensuring quality and curative effect of the medicine.

Description

technical field [0001] The invention relates to a pharmaceutical preparation of a hypoxia-inducible factor prolyl hydroxylase inhibitor, in particular to a pharmaceutical preparation of roxadustat, and a preparation method of the preparation. Background technique [0002] Renal anemia is anemia caused by the progress of various chronic kidney diseases (CKD), which is often related to the relative or absolute deficiency of erythropoietin secreted by the renal interstitium and the decreased sensitivity of patients to it, the shortened lifespan of red blood cells, and the microenvironment of the bone marrow hematopoietic system. Severe renal anemia will increase the mortality of CKD patients. There are about 119.5 million CKD patients in my country, of which about 400,000 receive dialysis (or peritoneal dialysis), and the rapid increase is double-digit every year. Therefore, more and more patients need to be treated for renal anemia. [0003] Roxadustat (Roxadustat, RDXT), joi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/472A61K47/40A61K47/32A61K47/26A61K47/38A61P7/06A61P13/12
CPCA61K31/472A61K9/205A61K9/2027A61P7/06A61P13/12A61K9/2095A61K9/2013A61K9/2054Y02A50/30
Inventor 刘营营杨西邈
Owner BEIJING WINSUNNY PHARMA CO LTD
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